Anti ulcer

Plant Research

for curing

U L C E R

Presented by

Dr. Sudhakar Kokate

Director PPRC, India

Ulcer

Ulcer is a sore which means it is an open

painful wound

A break in a bodily membrane

Peptic ulcer is one of the most common

gastrointestinal diseases

More common in adult males

PPRC/INDIA 01

causes

Stress

Hormones

Synthetic drugs

Alcohol

Smoking

Bacterial infection

(Helicobacter pylori)

Sepsis

PPRC/INDIA 02

symptoms

Loss of appetite

Stomach pain

Nausea

Weight loss

Vomiting

Blackish bowel movements

PPRC/INDIA 03

diagnosis

Observing upper gastrointestinal

(GT) series

Endoscopy

PPRC/INDIA 04

Types of ulcer

PPRC/INDIA 05

Peptic Ulcer – Gastrointestinal mucosa (Stomach ulcer) It is most common type of Peptic ulcer

Venous Ulcer – Wound in functioning of valves in the veins

Stress Ulcer – Anywhere within stomach Can be in Proximal duodenum

Ulcerative sarcoidosis – A cutaneous condition affecting people within Sarcoidosis

Types of ulcer

PPRC/INDIA 06

Ulcerative iiche planus – Rare variant of Lichen planus

Ulcerative colitis – Inflammatory bowel disease (IBD)

Ulcerative disposition – Abnormal distress associated with gastritis

Common forms of ulcer

Ulcer dermatology Break in skin

Pressure ulcers Bedsores

Genital ulcers Genital area

Ulcerative dermatitis Skin disorder

Corneal ulcer Cornea infective condition

Mouth ulcer Open sore in mouth

Aphthous ulcer Canker sore

PPRC/INDIA 07

Drugs presently available

PPRC/INDIA 08

There are number of modern anti- ulcer

drugs commercially available in the

market

But many drugs show various side-

effects evoking an urgent need for

alternative medicine

Common side-effects

PPRC/INDIA 09

Diarrhoea

Abdominal pain

Headache

Nausea

Vomiting

Dizziness

Depression

Constipation

First

effective phyto-drug

on

ulcer

PPRC/INDIA 10

carbenoxolone

PPRC/INDIA 11

Plant: Glycyrrhiza glabra

Ref: Brown H.M., Christie E., Colin Jones,

R.S.H. Finney, W.G. MacGregor, J.M.

Smith, W.G. Smith, F.M. Sullivan, A.L.

Tornoy and E.E. Turner 1959, Lancet 2:492

Glycyrrhiza glabra

PPRC/INDIA 12

One more

phyto-drug for u

on

ulcer

PPRC/INDIA 13

gefarnate

PPRC/INDIA 14

Plant: Brassica oleraceae

Ref:

1. Adami E.E. Marzzi-Uberti & C. Turba 1964 Arch.

Int. Pharmacodyn. Ther. 147, 113-145

2. Barbara L. Coriandesi M. Giorge – Conciata L.

Luchelta & G. Busca 1974, Current Medical

Research and opinion 2, 399-410

Brassica oleraceae

PPRC/INDIA 15

Abies pindrow

PPRC/INDIA 16

Abies pindrow

PPRC/INDIA 17

Family: Pinaceae

Leaf: Pet. Ether, benzene, chloroform extract

Protective role to aspirin induced Ulcer in Rat

Chemicals: Glycosides and steroid

Aegle marmelos

PPRC/INDIA 18

Aegle marmelos

PPRC/INDIA 19

Family: Rutaceae

Seeds: Chemical Luvangetin

Significant protection in Gastric ulcers in Rats

and Guinea pigs

Aloe barbadensis

PPRC/INDIA 20

Aloe barbadensis

PPRC/INDIA 21

Family: Liliaceae

Leaf extract: Reduced gastric lesions and

lesion index in experimental rats

Alpinia galanga

PPRC/INDIA 22

Alpinia galanga

PPRC/INDIA 23

Family: Zingiberaceae

Ethanolic extract of rhizomes exhibited

gastric antisecretory, anti-ulcer and

cytoprotective activities in rats

Althaea rosea

PPRC/INDIA 24

Althaea rosea

PPRC/INDIA 25

Family: Malvaceae

Stem decreased ulcer in rats

Chemicals: Polysaccharides

Amomum subulatum

PPRC/INDIA 26

Amomum subulatum

PPRC/INDIA 27

Family: Zingiberaceae

Methanolic extract reduced the gastric

motility

Anchusa strigosa

PPRC/INDIA 28

Anchusa strigosa

PPRC/INDIA 29

Family: Boraginaceae

Root extract showed significant protection

Andrographis paniculata

PPRC/INDIA 30

Andrographis paniculata

PPRC/INDIA 31

Family: Acanthaceae

A flavone produced significant reduction in

rats and guinea pigs

Aparisthmium cordatum

PPRC/INDIA 32

Aparisthmium cordatum

PPRC/INDIA 33

Family: Euphorbiaceae

Aparisthman, a diterpene showed effect in

different ulcer models

Asarum europaeum

PPRC/INDIA 34

Asarum europaeum

PPRC/INDIA 35

Family: Aristolochiaceae

Compound isolated from roots

Roots: showed anti-ulcer activity

Asparagus pubescens

PPRC/INDIA 36

Asparagus pubescens

PPRC/INDIA 37

Family: Liliaceae

Methanolic extract reduces ulcer

Asparagus racemosus

PPRC/INDIA 38

Asparagus racemosus

PPRC/INDIA 39

Family: Liliaceae

Dry roots prevented the formation of

duodenal ulcer in rats

Azadirachta indica

PPRC/INDIA 40

Azadirachta indica

PPRC/INDIA 41

Family: Meliaceae

The extracts of bark, leaves and nimbidin – oil

from seeds showed anti-ulcer activity in male

rats

Bacopa monnieri

PPRC/INDIA 42

Bacopa monnieri

PPRC/INDIA 43

Family: Scrophulariaceae

Juice produced significant anti-ulcer activity

Benincasa hispida

PPRC/INDIA 44

Benincasa hispida

PPRC/INDIA 45

Family: Cucurbitaceae

Different extracts are effective

Bidens pilosa

PPRC/INDIA 46

Bidens pilosa

PPRC/INDIA 47

Family: Asteraceae

Ethanolic, methylene chloride extracts

showed significant activity in rats

Brassica oleraceae

PPRC/INDIA 48

Brassica oleraceae

PPRC/INDIA 49

Family: Brassicaceae

Aqueous extract of leaves is significant

Bupleurum falcatum

PPRC/INDIA 50

Bupleurum falcatum

PPRC/INDIA 51

Family: Apiaceae

Polysaccharides fraction active against ulcer

in rats

Caesalpinia ferrea

PPRC/INDIA 52

Caesalpinia ferrea

PPRC/INDIA 53

Family: Caesalpiniaceae

Stem extract is effective

Calotropis procera

PPRC/INDIA 54

Calotropis procera

PPRC/INDIA 55

Family: Asclepidaceae

Chloroform extract is effective

Calligonum comosum

PPRC/INDIA 56

Calligonum comosum

PPRC/INDIA 57

Family: Polygonaceae

Ethanolic extracts of aerial parts is active

Camellia sinensis

PPRC/INDIA 58

Camellia sinensis

PPRC/INDIA 59

Family: Theaceae

Extract reduced the incidence

Cassia nigricans

PPRC/INDIA 60

Cassia nigricans

PPRC/INDIA 61

Family: Fabaceae

Extract of leaves is active

Catha edulis

PPRC/INDIA 62

Catha edulis

PPRC/INDIA 63

Family: Celastraceae

Extract of aerial parts produced anti-ulcer

activity

Centella asiatica

PPRC/INDIA 64

Centella asiatica

PPRC/INDIA 65

Family: Apiaceae

Leaf extract inhibited ulcer

Cinnamomum cassia

PPRC/INDIA 66

Cinnamomum cassia

PPRC/INDIA 67

Family: Lauraceae

Compounds from bark produced anti-ulcer

activity

Cistus incanus

PPRC/INDIA 68

Cistus incanus

PPRC/INDIA 69

Family: Cistaceae

Aqueous extract of aerial parts showed the

anti-ulcer activity in rats

Convolvulus pluricaulis

PPRC/INDIA 70

Convolvulus pluricaulis

PPRC/INDIA 71

Family: Convolvulaceae

Juice of fresh whole plant showed

ulcerogenic effects

Capaifera langsdorfii

PPRC/INDIA 72

Capaifera langsdorfii

PPRC/INDIA 73

Family: Fabaceae

Product obtained from stem bark protected

against gastric damage

Croton cajucara

PPRC/INDIA 74

Croton cajucara

PPRC/INDIA 75

Family: Euphorbiaceae

The essential oil significantly reduced gastric

lesions in different experimental models

Cryptomeria japonica

PPRC/INDIA 76

Cryptomeria japonica

PPRC/INDIA 77

Family: Cupressaceae

Essential oil from leaves exhibited strong

inhibitory activity

Curcuma longa

PPRC/INDIA 78

Curcuma longa

PPRC/INDIA 79

Family: Zingiberaceae

Ethanol extract produced significant results in

rats

Curcuma zedoaria

PPRC/INDIA 80

Curcuma zedoaria

PPRC/INDIA 81

Family: Zingiberaceae

Extract of rhizomes inhibited gastric ulcer

Diodia sarmentosa

PPRC/INDIA 82

Diodia sarmentosa

PPRC/INDIA 83

Family: Rubiaceae

Extract of whole plant is effective

Dombeya buettneri

PPRC/INDIA 84

Dombeya buettneri

PPRC/INDIA 85

Family: Sterculiaceae

Aqueous extract of leaves is effective

Emblica officinalis

PPRC/INDIA 86

Emblica officinalis

PPRC/INDIA 87

Family: Euphorbiaceae

Alcohol extract significantly inhibited the

development of gastric lesions in all test

models

Evodia rutaecarpa

PPRC/INDIA 88

Evodia rutaecarpa

PPRC/INDIA 89

Family: Rutaceae

Eight compounds synthesized from this plant

showed significant activity

Ferula species

PPRC/INDIA 90

Ferula species

PPRC/INDIA 91

Family: Apiaceae

Colloidal solution of Ferula species showed

significant protection

Ficus exasperata

PPRC/INDIA 92

Ficus exasperata

PPRC/INDIA 93

Family: Moraceae

Extracts of leaves produced effect in rats

Ficus racemosa

PPRC/INDIA 94

Ficus racemosa

PPRC/INDIA 95

Family: Moraceae

Aqueous extract of dried bark produced

effect in rats

Gingko biloba

PPRC/INDIA 96

Gingko biloba

PPRC/INDIA 97

Family: Gingkoaceae

Extracts are effective

Hippocratea excelsa

PPRC/INDIA 98

Hippocratea excelsa

PPRC/INDIA 99

Family: Hippocrataceae

Aqueous and ethanol extract of root, bark

showed an important gastroprotective effect

in rats

Iris germanica

PPRC/INDIA 100

Iris germanica

PPRC/INDIA 101

Family: Iruaceae

Terpene derivatives inhibited ulcer

Lippia alba

PPRC/INDIA 102

Lippia alba

PPRC/INDIA 103

Family: Verbenaceae

Oral administration prevented ulcer

Maytenus aquifolium

PPRC/INDIA 104

Maytenus aquifolium

PPRC/INDIA 105

Family: Celastraceae

Aqueous infusion reduced ulcer

Melia azedarachta

PPRC/INDIA 106

Melia azedarachta

PPRC/INDIA 107

Family: Meliaceae

Lipid components from fruits showed

significant activity

Microgramma squamulosa

PPRC/INDIA 108

Microgramma squamulosa

PPRC/INDIA 109

Family: Polypodiaceae

Extract of plant rhizome showed significant

activity

Momordica charantia

PPRC/INDIA 110

Momordica charantia

PPRC/INDIA 111

Family: Cucurbitaceae

The olive oil extract and dried powder of

fruits in filtered honey showed significant and

dose dependent anti-ulcerogenic activity

Musa paradisiaca

PPRC/INDIA 112

Musa paradisiaca

PPRC/INDIA 113

Family: Musaceae

Compounds from fruits reported to be active

in rats

Methanolic extract showed activity in rats

Myristica fragrans

PPRC/INDIA 114

Myristica fragrans

PPRC/INDIA 115

Family: Myristicaceae

Eugenol: Active principle of Nutmeg seeds

significantly reduced the gravity of gastric

ulcer

Nigella sativa

PPRC/INDIA 116

Nigella sativa

PPRC/INDIA 117

Family: Ranunculaceae

Oil significantly reduced ulcers in rats

Ocimum basilicum

PPRC/INDIA 118

Ocimum basilicum

PPRC/INDIA 119

Family: Laminaceae

Flavonoid and glycosides of leaves decreased

the ulcer index

Ocimum sanctum

PPRC/INDIA 120

Ocimum sanctum

PPRC/INDIA 121

Family: Laminaceae

Aqueous extract of leaves reduced ulcer in

rats

Opuntia ficus-indica

PPRC/INDIA 122

Opuntia ficus-indica

PPRC/INDIA 123

Family: Cactaceae

Showed significant action in rats

Paedaria foetida

PPRC/INDIA 124

Paedaria foetida

PPRC/INDIA 125

Family: Rubiaceae

Aqueous extract, ethanol extract and leaf

juice revealed significant anti-ulcer activity

Panax ginseng

PPRC/INDIA 126

Panax ginseng

PPRC/INDIA 127

Family: Araliaceae

Polysaccharides obtained from leaves

produced anti-ulcer activity

Parkia biglandulosa

PPRC/INDIA 128

Parkia biglandulosa

PPRC/INDIA 129

Family: Fabiaceae

Ethanol extract of leaves is active

Phyllanthus emblica

PPRC/INDIA 130

Phyllanthus emblica

PPRC/INDIA 131

Family: Euphorbiaceae

Butanol extract of water fraction of fruits

active

Picrorrhiza kurroa

PPRC/INDIA 132

Picrorrhiza kurroa

PPRC/INDIA 133

Family: Scrophulariaceae

Ethanol extract of rhizomes and roots

prevented ulcer

Piper betle

PPRC/INDIA 134

Piper betle

PPRC/INDIA 135

Family: Piperaceae

Alcoholic extract of leaves prevented

Stachytarpheta cayennensis

PPRC/INDIA 136

Stachytarpheta cayennensis

PPRC/INDIA 137

Family: Verbenaceae

Aqueous extract of whole plant inhibited

ulcerogenic activity

Strychnos nux-vomica

PPRC/INDIA 138

Strychnos nux-vomica

PPRC/INDIA 139

Family: Loganiaceae

Oral administration of seed powder produced

anti-ulcer activity

Styrax camporum

PPRC/INDIA 140

Styrax camporum

PPRC/INDIA 141

Family: Styracaceae

Stem extract prevented ulcerogenic activity

Tectona grandis

PPRC/INDIA 142

Tectona grandis

PPRC/INDIA 143

Family: Verbenaceae

Ethanol extract of bark and wood chips waas

found to have significant activity

Teucrium buxifolium

PPRC/INDIA 144

Teucrium buxifolium

PPRC/INDIA 145

Family: Lamiaceae

Significant ulcerogenic activity noted in

addition to other anti-inflammatory

properties

Theobroma cacao

PPRC/INDIA 146

Theobroma cacao

PPRC/INDIA 147

Family: Sterculiaceae

Compound prevented ulcer

Trigonella foenum-graenum

PPRC/INDIA 148

Trigonella foenum-graenum

PPRC/INDIA 149

Family: Fabaceae

Aqueous extract of seeds show significant

ulcer protective effects

Turnea ulmifolia

PPRC/INDIA 150

Turnea ulmifolia

PPRC/INDIA 151

Family: Turneraceae

Ethanolic extract of aerial parts showed

activity in rats

Viburnum dilatatum

PPRC/INDIA 152

Viburnum dilatatum

PPRC/INDIA 153

Family: Caprifoliaceae

Effective against ulcerogenic activity

Voacanga africana

PPRC/INDIA 154

Voacanga africana

PPRC/INDIA 155

Family: Apocynaceae

Methanolic extract exhibited activity

Wilbrandia ebracteata

PPRC/INDIA 156

Wilbrandia ebracteata

PPRC/INDIA 157

Family: Cucurbitaceae

Leaf extract reduced gastric damage

Withania somnifera

PPRC/INDIA 158

Withania somnifera

PPRC/INDIA 159

Family: Solanaceae

Oral administration prevented ulcer

Zingiber officinale

PPRC/INDIA 160

Zingiber officinale

PPRC/INDIA 161

Family: Zingiberaceae

Acetone extract of rhizome showed activity

Thank You!!

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