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©2017 | www.agribodytech.com 1
Expanding Global Food Supply by Significantly Increasing Crop Yields Using Patented Gene TechnologyJerry Feitelson, Ph.D., Co-Founder & CEO | jerry@agribodytech.com | (858) 349-3603
©2017 | www.agribodytech.com 2©2017 | www.agribodytech.com
THEPROBLEM
• YIELD: Highest value trait to farmersØ Conventional breeding reaching yield limits
• Tens of $Billions in crop loss caused by:Ø Post-harvest senescenceØ Disease (bacterial and fungal pathogens)Ø Stress (drought, low nutrients, salt, cold, heat)
©2017 | www.agribodytech.com 3©2017 | www.agribodytech.com
OURDISRUPTIVESOLUTION
License or co-develop
proprietary Genome Edited seeds
with innovative seed companies in
forage, row or specialty crops having
ULTRA HIGH YIELD &
STRESS RESISTANCE.
-- Avoid GMO controversies --
©2017 | www.agribodytech.com 4©2017 | www.agribodytech.com
TECHNOLOGY COMPARISONS
Conventional Transgenic (GM) Genome EditedUSDA-APHISBiotechnology Unregulated Regulated article:
7 CFR part 340Unregulated
(small deletions)
FDA Voluntary Biotech Consultation Voluntary
R&D Timeline Standard +3 to 5 years +1 year
Labeling None Public Law 114-216 None
ATI technology - Upregulate eIF-5A3 expression Lower DHS activity
Crop Traits -• Greater Biomass• Similar Quality• Abiotic StressT
• ↓ Senescence• ↑ Shelf Life• ↑ Biomass/Yield• ↑ StressT
• ↑ DiseaseR
Cost Standard
• Tech Access Fee• Milestone Payments• Royalties
• Tech Access Fee• Milestone Payments• Royalties
©2017 | www.agribodytech.com 5
HypusineeIF-5ADHS
How? Genetically modify a biological switchThe eIF-5A/DHS hypusination pathway promotes either cell growth/division or cell death (apoptosis)
−LysineeIF-5A
Cell Growth/Division
CellApoptosis
• Increased biomass and seed yield
• Enhanced tolerance to stress & disease
+
©2017 | www.agribodytech.com 6
Value Proposition
1. Enhanced Shelf Life (↓ eIF-5A1 senescence)
2. Enhanced Disease Tolerance (↓ eIF-5A2 pathogen)
3. Enhanced Seed Yield / Biomass (↑ eIF-5A3 growth)
↓ DHS : Positively effects all 3 traits
©2017 | www.agribodytech.com 7
1. Enhanced Shelf Life (↓ eIF-5A1 / ↓ DHS)
Agribody
Control
At harvest 7 days 14 days
Control
Agribody
Days 14 21 280 44
Delayed leaf & flower senescence, fruit softening & spoilage
2 - 3X longer shelf life
©2017 | www.agribodytech.com 8
Tolerance to fungal / bacterial disease 2. Enhanced Disease Tolerance (↓ eIF-5A2 / ↓ DHS)
Control(Sigatoka-infected)
Banana
Pseudomonas syringae infection
Tomato
AgribodyControl
Agribody (Sigatoka-reduced)
©2017 | www.agribodytech.com 9
• 50–300% increased vegetative & reproductive mass• Enlarged root structure• Enhanced stress tolerance
− drought, nutrient, salt, heat, cold
3. Enhanced Biomass in Canola (↓ DHS)
Control Agribody Control AgribodyRef: Ma et al. (2005) Physiol. Plant. 124:493-503
©2017 | www.agribodytech.com 10
Transgenic Alfalfa Field Trial
©2017 | www.agribodytech.com 11
�
CONTROL AGRIBODY
• 3rd most valuable crop
• >$8B hay market in U.S.
• Alfalfa breeding challenge is improvement of both forage yield and quality− Often inversely correlated− Low yearly gains: <0.2 – 0.3%
• Elite varieties of alfalfa developed that constitutively overexpressed eIF-5A3− Over 2 years of field trials
averaged 20 – 45% higher yields− Maintained high forage quality− Manuscript submitted
FIELD TRIAL SUCCESS:ALFALFA
©2017 | www.agribodytech.com 12
Higher yields do not result in
significantly lower quality
Field Trial Success – AlfalfaCP: Crude ProteinADF: Acid Detergent FiberNDF: Neutral Detergent FiberRFQ: Relative Forage Quality
2010Field trial established
Salem, WI
2011-2012Agronomic evaluation, forage yield & quality
measured22 alfalfa clones
2012-2013Confirmed data
22 alfalfa clonesThree lines significant at 95%; others at 90%
eIF-5A3 Alfalfa
Hay Category CP ADF NDF RFQ
Supreme >22 <27 <34 >185
Hay Yield Premium 20-22 27-29 34-36 170-185
DW (g) % Control Good 18-20 29-32 36-40 150-170
2011
008-PIP-036 199.8 136% 21.5 28.7 34.2 200.6
008-PIP-029 186.6 127% 22.2 28.4 33.8 201.1
009-PIP-076 183.7 125% 22.3 28.2 33.6 202.9
Control 146.5 100% 22.0 27.0 32.1 216.3
2012
009-PIP-010 144.8 133% 18.9 30.4 36.3 172.9
008-PIP-046 132.0 122% 18.8 30.5 36.4 170.9
008-PIP-008 124.2 114% 19.0 31.0 36.9 170.6
Control 108.6 100% 18.8 30.0 35.9 176.7
©2017 | www.agribodytech.com 1313
• Broad Coverage− 16 issued US Patents + 5 published US Patent Applications− Foreign counterparts in several countries− New applications for genome editing of DHS− CRISPR license from Benson Hill Biosystems
• Matter & Methods claims− eIF-5A overexpression has
important phenotypes• Higher seed & biomass yields• Tolerance to abiotic stresses
− DHS knock-downs have clear phenotypes• Delayed senescence• Larger leaves• Higher seed yields• Stress tolerance
Strong IP Portfolio
Any genetic modification of any plant that either upregulates eIF-5A or downregulates DHS infringes ATI’s patent.
“
”
©2017 | www.agribodytech.com 1414
ATI Executive Team
Paul KreutzCorporate Counsel
• Represented many VC firms• Counsels & helps structure
growth-oriented entrepreneurial enterprises
• B.A. (Yale), LL.B. (Stanford)
Jerry Feitelson, Ph.D.CEO / Co-Founder
• >30 years R&D, IP, Licensing & Bus Dev experience
• Managed $10Mil royalties; Negotiated $7Mil license
• Patented B.t. genes/proteins lead to $850Mil valuation
• B.S. (MIT), Ph.D. (Stanford)
John Thompson, Ph.D.Chief Scientist / Co-Founder
• U. of Waterloo (Professor Emeritus, Associate VP)
• Invented eIF-5A/DHS technology
• B.S. (Toronto), Ph.D. (Alberta), Fellow of Royal Society of Canada
Jim GoodeActing CFO
• 35 years managing financial/ admin functions of high-tech, biotech and start-ups
• Raised >$100Mil• MBA (UCLA), CPA (Arthur
Young)
©2017 | www.agribodytech.com 1515
ATI Consultants / Advisors
Alan Bennett, Ph.D.Chair, SAB
• UC-Davis (Distinguished Professor of Plant Science)
• Transformed/characterized elite alfalfa with eIF-5A
• Runs advanced genetics lab• B.S. (UC-Davis), Ph.D.
(Cornell)
Jerry Caulder, Ph.D.Advisor
• Known as the “Father of Agricultural Biotechnology”
• 15 years with Monsanto; as CEO, built $1.2Bil valuation
• Lead 2 other companies, Chair of Athenix, sold for $400Mil. Founded Finistere Ventures
• B.S. (SE Missouri State U.), Ph.D. (U. Missouri)
Vaughn Smider, M.D., Ph.D.Advisor
• CSO of Sevion Therapeutics, Founder/President of precursor company, Fabrus.
• Associate Professor at The Scripps Research Institute
• Leadership Council for American Cancer Society
• B.A (Hiram College), M.D. & Ph.D. (Stanford U.)
Craig WilliamsField Trials / Regulatory
• 25 years experience managing seed companies
• Knowledgeable in seed business operations, regulatory affairs, field trials, M&A due diligence
• B.S. (Bradley U.)
©2017 | www.agribodytech.com 16©2017 | www.agribodytech.com
Potatoes
Transgenic technology attractive to major players
Bananas
Corn & Soy Alfalfa
CRISPR
©2017 | www.agribodytech.com 1717
Summary
ATI seeks to license
& co-develop ultra-high
yield, stress-resistant
crops with established
seed companies
• CEO & Management TeamEntrepreneurs experienced in Licensing/JVs
• Proof of Efficacy
• Broad IP
• LOI & JV terms: alfalfa seed co.
• Genome editing avoids GMO issues
©2017 | www.agribodytech.com 18
THANK YOU!Jerry Feitelson, Ph.D., Co-Founder & CEOjerry@agribodytech.com | (858) 349-3603 | www.agribodytech.com
©2017 | www.agribodytech.com 19
Jerry Feitelson, Ph.D.CEO – Agribody Technologies, Inc.
BIOTECHNOLOGY COLLABORATION NETWORKS STRATEGIC PLANNING
LICENSING/JVs INTELLECTUAL PROPERTY TECHNOLOGY TRANSFERSenior-level R&D and business development executive, with extensive entrepreneurial, industrial andacademic experience n >30 years of industrial research experience in drug discovery, agriculturalbiotechnology, proteomics, IP/marketing and biofuels n Technical business plan writing n Ledteams that discovered and developed commercially important families of pesticidal proteins,proteomics solutions, advanced analytical chemistry solutions, and biofuel germplasm n Excellentnetworker – set up several collaboration networks in different scientific fields n Skilledcommunicator n Productive inventor – 14 issued and 7 pending U.S. patents n 40 peer-reviewed publications & numerous invited lectures n Very customer-focused, strong relationshipbuilder.
M.I.T.(B.S.)
Stanford(Ph.D.)
1971 19911976 19861981 20011996 2006 2011 2016
J.I.I.UK
AmCy &Rutgers U.
Steptomyces Genetics
Mycogen
Agricultural Biotech
GenWay
Proteomics
Global Clean Energy
IP/Marketing
BiofuelsAkkadix
GBF
Agribody
Ag Biotech
BeckmanCoulter
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