Agribody Technologies - Strategic Partner deck 2017-02-26

©2017 | www.agribodytech.com 1

Expanding Global Food Supply by Significantly Increasing Crop Yields Using Patented Gene TechnologyJerry Feitelson, Ph.D., Co-Founder & CEO | [email protected] | (858) 349-3603

©2017 | www.agribodytech.com 2©2017 | www.agribodytech.com

THEPROBLEM

• YIELD: Highest value trait to farmersØ Conventional breeding reaching yield limits

• Tens of $Billions in crop loss caused by:Ø Post-harvest senescenceØ Disease (bacterial and fungal pathogens)Ø Stress (drought, low nutrients, salt, cold, heat)


OURDISRUPTIVESOLUTION

License or co-develop

proprietary Genome Edited seeds

with innovative seed companies in

forage, row or specialty crops having

ULTRA HIGH YIELD &

STRESS RESISTANCE.

-- Avoid GMO controversies --


TECHNOLOGY COMPARISONS

Conventional Transgenic (GM) Genome EditedUSDA-APHISBiotechnology Unregulated Regulated article:

7 CFR part 340Unregulated

(small deletions)

FDA Voluntary Biotech Consultation Voluntary

R&D Timeline Standard +3 to 5 years +1 year

Labeling None Public Law 114-216 None

ATI technology - Upregulate eIF-5A3 expression Lower DHS activity

Crop Traits -• Greater Biomass• Similar Quality• Abiotic StressT

• ↓ Senescence• ↑ Shelf Life• ↑ Biomass/Yield• ↑ StressT

• ↑ DiseaseR

Cost Standard

• Tech Access Fee• Milestone Payments• Royalties

• Tech Access Fee• Milestone Payments• Royalties


HypusineeIF-5ADHS

How? Genetically modify a biological switchThe eIF-5A/DHS hypusination pathway promotes either cell growth/division or cell death (apoptosis)

−LysineeIF-5A

Cell Growth/Division

CellApoptosis

• Increased biomass and seed yield

• Enhanced tolerance to stress & disease

+


Value Proposition

1. Enhanced Shelf Life (↓ eIF-5A1 senescence)

2. Enhanced Disease Tolerance (↓ eIF-5A2 pathogen)

3. Enhanced Seed Yield / Biomass (↑ eIF-5A3 growth)

↓ DHS : Positively effects all 3 traits


1. Enhanced Shelf Life (↓ eIF-5A1 / ↓ DHS)

Agribody

Control

At harvest 7 days 14 days

Control

Agribody

Days 14 21 280 44

Delayed leaf & flower senescence, fruit softening & spoilage

2 - 3X longer shelf life


Tolerance to fungal / bacterial disease 2. Enhanced Disease Tolerance (↓ eIF-5A2 / ↓ DHS)

Control(Sigatoka-infected)

Banana

Pseudomonas syringae infection

Tomato

AgribodyControl

Agribody (Sigatoka-reduced)


• 50–300% increased vegetative & reproductive mass• Enlarged root structure• Enhanced stress tolerance

− drought, nutrient, salt, heat, cold

3. Enhanced Biomass in Canola (↓ DHS)

Control Agribody Control AgribodyRef: Ma et al. (2005) Physiol. Plant. 124:493-503


Transgenic Alfalfa Field Trial


�

CONTROL AGRIBODY

• 3rd most valuable crop

• >$8B hay market in U.S.

• Alfalfa breeding challenge is improvement of both forage yield and quality− Often inversely correlated− Low yearly gains: <0.2 – 0.3%

• Elite varieties of alfalfa developed that constitutively overexpressed eIF-5A3− Over 2 years of field trials

averaged 20 – 45% higher yields− Maintained high forage quality− Manuscript submitted

FIELD TRIAL SUCCESS:ALFALFA


Higher yields do not result in

significantly lower quality

Field Trial Success – AlfalfaCP: Crude ProteinADF: Acid Detergent FiberNDF: Neutral Detergent FiberRFQ: Relative Forage Quality

2010Field trial established

Salem, WI

2011-2012Agronomic evaluation, forage yield & quality

measured22 alfalfa clones

2012-2013Confirmed data

22 alfalfa clonesThree lines significant at 95%; others at 90%

eIF-5A3 Alfalfa

Hay Category CP ADF NDF RFQ

Supreme >22 <27 <34 >185

Hay Yield Premium 20-22 27-29 34-36 170-185

DW (g) % Control Good 18-20 29-32 36-40 150-170

2011

008-PIP-036 199.8 136% 21.5 28.7 34.2 200.6

008-PIP-029 186.6 127% 22.2 28.4 33.8 201.1

009-PIP-076 183.7 125% 22.3 28.2 33.6 202.9

Control 146.5 100% 22.0 27.0 32.1 216.3

2012

009-PIP-010 144.8 133% 18.9 30.4 36.3 172.9

008-PIP-046 132.0 122% 18.8 30.5 36.4 170.9

008-PIP-008 124.2 114% 19.0 31.0 36.9 170.6

Control 108.6 100% 18.8 30.0 35.9 176.7


• Broad Coverage− 16 issued US Patents + 5 published US Patent Applications− Foreign counterparts in several countries− New applications for genome editing of DHS− CRISPR license from Benson Hill Biosystems

• Matter & Methods claims− eIF-5A overexpression has

important phenotypes• Higher seed & biomass yields• Tolerance to abiotic stresses

− DHS knock-downs have clear phenotypes• Delayed senescence• Larger leaves• Higher seed yields• Stress tolerance

Strong IP Portfolio

Any genetic modification of any plant that either upregulates eIF-5A or downregulates DHS infringes ATI’s patent.

“

”


ATI Executive Team

Paul KreutzCorporate Counsel

• Represented many VC firms• Counsels & helps structure

growth-oriented entrepreneurial enterprises

• B.A. (Yale), LL.B. (Stanford)

Jerry Feitelson, Ph.D.CEO / Co-Founder

• >30 years R&D, IP, Licensing & Bus Dev experience

• Managed $10Mil royalties; Negotiated $7Mil license

• Patented B.t. genes/proteins lead to $850Mil valuation

• B.S. (MIT), Ph.D. (Stanford)

John Thompson, Ph.D.Chief Scientist / Co-Founder

• U. of Waterloo (Professor Emeritus, Associate VP)

• Invented eIF-5A/DHS technology

• B.S. (Toronto), Ph.D. (Alberta), Fellow of Royal Society of Canada

Jim GoodeActing CFO

• 35 years managing financial/ admin functions of high-tech, biotech and start-ups

• Raised >$100Mil• MBA (UCLA), CPA (Arthur

Young)


ATI Consultants / Advisors

Alan Bennett, Ph.D.Chair, SAB

• UC-Davis (Distinguished Professor of Plant Science)

• Transformed/characterized elite alfalfa with eIF-5A

• Runs advanced genetics lab• B.S. (UC-Davis), Ph.D.

(Cornell)

Jerry Caulder, Ph.D.Advisor

• Known as the “Father of Agricultural Biotechnology”

• 15 years with Monsanto; as CEO, built $1.2Bil valuation

• Lead 2 other companies, Chair of Athenix, sold for $400Mil. Founded Finistere Ventures

• B.S. (SE Missouri State U.), Ph.D. (U. Missouri)

Vaughn Smider, M.D., Ph.D.Advisor

• CSO of Sevion Therapeutics, Founder/President of precursor company, Fabrus.

• Associate Professor at The Scripps Research Institute

• Leadership Council for American Cancer Society

• B.A (Hiram College), M.D. & Ph.D. (Stanford U.)

Craig WilliamsField Trials / Regulatory

• 25 years experience managing seed companies

• Knowledgeable in seed business operations, regulatory affairs, field trials, M&A due diligence

• B.S. (Bradley U.)


Potatoes

Transgenic technology attractive to major players

Bananas

Corn & Soy Alfalfa

CRISPR


Summary

ATI seeks to license

& co-develop ultra-high

yield, stress-resistant

crops with established

seed companies

• CEO & Management TeamEntrepreneurs experienced in Licensing/JVs

• Proof of Efficacy

• Broad IP

• LOI & JV terms: alfalfa seed co.

• Genome editing avoids GMO issues


THANK YOU!Jerry Feitelson, Ph.D., Co-Founder & [email protected] | (858) 349-3603 | www.agribodytech.com


Jerry Feitelson, Ph.D.CEO – Agribody Technologies, Inc.

BIOTECHNOLOGY COLLABORATION NETWORKS STRATEGIC PLANNING

LICENSING/JVs INTELLECTUAL PROPERTY TECHNOLOGY TRANSFERSenior-level R&D and business development executive, with extensive entrepreneurial, industrial andacademic experience n >30 years of industrial research experience in drug discovery, agriculturalbiotechnology, proteomics, IP/marketing and biofuels n Technical business plan writing n Ledteams that discovered and developed commercially important families of pesticidal proteins,proteomics solutions, advanced analytical chemistry solutions, and biofuel germplasm n Excellentnetworker – set up several collaboration networks in different scientific fields n Skilledcommunicator n Productive inventor – 14 issued and 7 pending U.S. patents n 40 peer-reviewed publications & numerous invited lectures n Very customer-focused, strong relationshipbuilder.

M.I.T.(B.S.)

Stanford(Ph.D.)

1971 19911976 19861981 20011996 2006 2011 2016

J.I.I.UK

AmCy &Rutgers U.

Steptomyces Genetics

Mycogen

Agricultural Biotech

GenWay

Proteomics

Global Clean Energy

IP/Marketing

BiofuelsAkkadix

GBF

Agribody

Ag Biotech

BeckmanCoulter