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Tube Handler for sorting, cherry-picking, rearraying, decoding, and weighing tubes from Matrix, Micronic, ABgene, and Corning.
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BioMicroLab
Sample Management Automation
Tube and Vial Handling
Volume
Verification
SampleScan 2D
barcode readers
About BioMicroLab
BioMicroLab’s parent company: CopyPro, Inc. 20-year track record in manufacturing material handling products
Modern CNC sheet metal/machined metal production systems
In-house engineering team
Focus: Industrial products with easy-to-use software
Holds several US Patents
BioMicroLab’s history 2001 - XL20 Tube Handling Instrument development begins
2003 - BioMicroLab incorporates
2004 - XL20 launched at Lab Automation Conference
2004 - Released 2D tube rack and single tube readers
2005 - XL9 Tube Handler introduced
2006 - Launched SampleScan HS and VolumeCheck at Lab
Automation 2006
2007 – Shipped 100th XL20 Tube Handling System
2008 – Released XL100 Vial Handling Instrument
2009 – Introduced the SampleScan Mini and SampleScan Plus
2010 – Released Decapper and Automated Capper for XL100
2011 – Added Liquid Handling to the XL100
Typical BioMicroLab Customers
• Compound Sample Management Laboratory
– Large Pharmaceutical Companies
• Bench top automation for central sample repositories
– Small and Large Biotech Companies
• Main robot for handling laboratory sample libraries
• Genomic Research Facilities
– Usually research departments at Hospitals and Universities
• Genomic Core Facilities
• Tissue Banks
• DNA Banks
• BioBanks
Sample Management Automation
Tube Handling Instruments
– XL20 Tube Handling Instrument
– XL9 Tube Handling Instrument
– XL100 Vial Handling Instrument
– MX4 Sort and Scan
SampleScan 2D Readers
– SampleScan 96 – multi-rack reader
– SampleScan Plus – single tube reader
– SampleScan HS – camera based high speed reader
– SampleScan Mini – scanner based high speed reader
Volume Verification Instruments
– VolumeCheck – ultrasonic detection of sample in well plates
– XL20 Automated Balance – gravimetric volume tracking
– XL20 LevelCheck – sensor detects sample meniscus in capped vials
SampleScan 2D Barcode Readers
SampleScan Plus Single Tube Reader
SampleScan Mini Single Rack Reader
SampleScan HS Single Rack
High Throughput
SampleScan Mini with1D reader Fully Automated Single Rack Reader
SampleScan 96 Entry-Level
Single Rack Scanner
XL20 Tube Handler Applications
Key XL20 applications
Automated analytical balance used to confirm sample volume
Automated tube sorter to manage handling of sample libraries
Typical applications
Cherry Picking tubes
Re-arraying sample libraries
Handling samples from combinational chemistry labs
Weighing tubes to calculate sample volume
LevelCheck tubes for fast volume data return
XL20 Features & Benefits
Features
- Small bench top robot for 96 tube sample format
- Processes 0.3 ml to 1.4 ml tubes from Micronic, ABgene, Corning, & MATRIX
- Automates tube sorting, 2D scanning, and weighing
- Faster & less costly than competing automated balances
- Quick integration & deployment (operational the day of installation)
Benefits
- Saves time and resources
- Extend laboratory’s sample
tracking capabilities
- Leverages laboratory’s investment
in 2D tube storage systems
- Ease-of-use allows operation by a
wide variety of users
XL20 Hardware Options
XL20 Instrument Options
2D barcode reader module
Integrated single tube reader
Decodes 2D marked tubes while sorting
Analytical Balance module
captures tube weight
0.0001g readability
Software application specific to net weight capture of tube sample
LevelCheck module
Non-contact sensor detects sample meniscus and returns volume data
2D Camera Option
2D Camera Module
Scans and decodes 2D
barcoded vials
Captures 2D barcode while
processing tubes
Module does not use tube
rack nest
Analytical Balance Option
Analytical Balance
Weighing range 60g
Readability at the interface 0.0001g
Reproducibility = +/- 0.0001g
Linearity <= +/- .0002g
Response time average <= 2 sec
LevelCheck Option
LevelCheck Module for XL20/XL9 Non-Contact sample volume detection
Accuracy: +/- 10 – 15uL
Collects volume data while sorting, rearraying, and capturing 2D barcodes
LevelCheck one rack in about 15 minutes
Sample image and capture recall – store tube images with 2D barcode data
XL20 systems can be field upgraded with the LevelCheck system
No loss of sorting positions
when scale is present
LevelCheck uses tube rack position
#5 on XL20 sorting platform
XL9 Tube Handling Instrument
XL20 & XL9 robotics are identical
XL20 has 28.5” width and 20 rack positions
XL9 has 18” width and 9 rack positions
Workflow with BioMicroLab software
Work List Mode
LIMS (database)
Input .csv
XL20
Output .csv
1. Query for sample list
2. Create XL20 input
format (.csv)
3. XL20 imports and
sorts tubes
5. Import file for
LIMS database update
4. XL20 creates
output file for each
rack (.csv)
Workflow with ActiveX software
LIMS
(database) XL20
Query for sample list
XL20 sorts/weighs
tubes
Sorting data
automatically updates
LIMS
Note: ActiveX requires customer IT group provide database integration software support.
XL Tube Handler Processing Modes
Tube Handler modes of operation • Work List Based – rearray applications
1. Sequential
• Racks are processed in work list order
only
2. Random
• Racks are processed in random order
• No Work List Required – pick and place vial from same
location
1. Tare/Gross Weigh
• Tare and gross weight of vials
• Streamlined weighing mode
2. Data Collection Mode
• Typically used to collect linear barcodes
or vial weight with XL100
XL20 Tube Handler Input Work List
Work list example
Source Rack ID
Source Tube Location
Expected Tube 2D bar
code (optional)
Target Rack ID
Target Tube Location
XL20 Tube Handler Software Features
Main Processing Screen
– Work list controlled movement of
tubes
– Confirms tube ID from work list
with captured 2D data
– Captures image of 2D barcode for
error handling
– Sample weight capture displayed
– Software generates Job ID for
tracking in your LIMS system
– Start, Stop, and Pause
Click to import
work list
Input File Settings
Input Files Settings
Provides flexibility for importing
work lists with header files or extra
characters
XL20 Tube Handler Tray Setup
Work List Software
– Assignment of racks to XL20
platform locations
– Color coded interface guides user
through tube rack loading process
– Supports input from hand held bar
code scanner
XL9 Tube Handling System displayed
XL20 Tube Rack Loading Process
Scanning the tube rack position
on XL20/XL9 platform
Scanning the barcode ID
label on the tube rack
XL9 Tube Handling System displayed
XL20 Tube Handler Software Features
To Start - press job
initiator button
Can view live video vs.
captured bitmap
Barcode Read
Returns decoded
barcode
Status column
OK
Bar code mismatch
Weight column
Returns weight
Captures data
while processing
tubes
XL20 Work List Mode Output File
Generates LIMS output file for use
by sample tracking systems
Operator can pre-determine content of
output file
Output file can be placed in folder on a
network
Example of Work List Processing
Mode Output
LevelCheck Output
LevelCheck Output
Volume data output in .csv output file
Volume data associated with 2D barcode
via output file
Tube images output .JPEG
LevelCheck output file example LevelCheck visual inspection
XL20 Tube Handler Tare/Gross Weigh
Tare Gross Weighing Mode
Data Collection mode
Interactive selection of tube
positions during the weighing mode
set up
Provides full flexibility for a wide
variety of weighing applications
Tare/Gross Weigh Output File Options
Output File Options for
Tare/Gross Weigh Mode
Operator can pre-determine content
of output file
Output file can be placed in folder on
a network
Example of Work List Processing
Mode Output
XL20 Tube Handler Error Handling
Error handling for operations
Tube Movement:
Picking Tube
Placing Tube
Bar Code Decoding:
Barcode Miss-match
Decode failure
Error handling features selectable
by the operator
Audible Alarms
XL20 Tube Handler Robot Control
Manual control of robot via
loader control panel
Troubleshooting
Individual tube movements
Calibrate Scale
Calibrate Camera Option
XL20 Product Specifications
Operating Requirements:
Electrical: 110-220 VAC 60Hz
Environment: Ambient Room Model: 4 C to 40 C, 10-90% RH
Cold Room Model: -4 C to 40 C, 10-90% RH
Machine Specifications:
Weight: XL20 : 42 lbs
XL9: 22 lbs
Dimensions: XL20: 28.25" W x 21" L x 16" H
XL9: 18.00” W x 17” L x 16” H
XL20 Product Specifications
PC System Requirements:
Windows XP/Vista/7
2.2+ GHz computer processor
512MB RAM (1GB recommended)
Standard Serial and USB Ports
BioMicroLab Service and Support
BioMicroLab Service Support Center
– Concord, CA, USA
Service Offering
– Service Agreements
– Phone
– Library of technical data sheets
– Preventative Maintenance Service Program
Onsite Support
– BioMicroLab Direct
– Reseller support network
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