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VISTAS INVISTAS IN
HERBAL TECHNOLOGY HERBAL TECHNOLOGY
The most powerful The most powerful technologies of 21technologies of 21stst century century
• Information technology (IT)
• Biotechnology (BT)
• Nanotechnology (NT)
• Herbal technology (HT)Herbal technology (HT)
Herbal TechnologyHerbal Technology
Herbal technology (HT) deals Herbal technology (HT) deals with various aspects of utilizing with various aspects of utilizing plants for human welfare.plants for human welfare.
• The five prominent areas in HT are: Phytomedicines/Herbal healthcare Phytomedicines/Herbal healthcare products, Natural dyes, Biopesticides, products, Natural dyes, Biopesticides, Biofertilizers and Biofuels. Biofertilizers and Biofuels.
PHYTOMEDICINEPHYTOMEDICINE
Any medicine or healthcare product derived from plants (phyto = of plant origin)
Includes: • PhytopharmaceuticalsPhytopharmaceuticals - Drugs• NutraceuticalsNutraceuticals - Functional food• CosmeceuticalsCosmeceuticals - Functional makeup • AgriceuticalsAgriceuticals - Fungicides, pesticides, etc.• Plant/Natural dyesPlant/Natural dyes
Phytomedicines in differentPhytomedicines in different Medicare systems Medicare systems
• Allopathic system (Modern medicine)• Homeopathic system (Modern medicine)
Alternative/complimentary systems:• Ayurveda, Sidha and Unani systems• Chinese and Tibetan systems• Folk medicine• Naturopathy• Aromatherapy• Grandma’s medicines/Home remedies
Many of the modern drugs have been derived from plants
• 25 percent of active ingredients of modern medicine are obtained from plants
• They are either obtained directly or are synthetic derivatives of plant derived molecules
Common herbsCommon herbs of our homesteadsof our homesteads
TRIPHALATRIPHALA
TRIKATUTRIKATU
Important discoveries
therapeutically useful biodynamic
molecules from plants
Vincristine and VinblastineVincristine and Vinblastine
Catharanthus roseus
Vincristine and VinblastineVincristine and Vinblastine
• VincristineVincristine is used in the treatment of lymphatic leucaemia, lung cancer and breast cancer
• VinblastineVinblastine is used in the treatment of Hodgkin disease; renal, testicular, head and neck cancer
Both are alkaloids isolated from Both are alkaloids isolated from Catheranthus roseusCatheranthus roseus (Ushamlari, Savamnari) (Ushamlari, Savamnari)
Morphine
Papaver somniferum
ReserpineReserpine
Rauwolfia serpentinaRauwolfia serpentina
TaxolTaxol
• One of the most promising compounds in the treatment of cancer
• It is a diterpenoid isolated form Taxus brevifolia and Taxus baccata
T. brevifolia
ArtemisinineArtemisinine
Artemisia annuaArtemisia annua
Artemisinine, the most promising antimalarial drug
• Artemisinine is isolated from Artemisia annua by Chinese scientists
• Among its synthetic derivatives Artementher and Arteether are important
AntioxidantsAntioxidants
• They are Phenolic substances derived from They are Phenolic substances derived from edible plants which are capable of edible plants which are capable of scavenging the toxic free radicals from scavenging the toxic free radicals from human body.human body.
• These secondary metabolites are known for their anti-inflammatory and anti-tumoral activities which suggest their potential in preventing cancer and coronary heart diseases.
CurcuminCurcumin
Curcuma longa
GingerolGingerol
Zingiber officinale
Global trend in herbal drug Global trend in herbal drug industryindustry
• Growing preference for phytomedicinesGrowing preference for phytomedicines (especially due to toxicity and side effects of synthetic drugs)
• Billions of dollar worth herbal healthcare Billions of dollar worth herbal healthcare products are sold annuallyproducts are sold annually
WHO projection for the year 2050: Five trillion US dollarsFive trillion US dollars
Approach to developing new Approach to developing new generation herbal healthcare productsgeneration herbal healthcare products
Traditional/Indigenous Knowledge survey
Taxonomic screening
Plant collection
Phytochemical screening
Isolation ofActive principles
PharmacologicalScreening-I
DrDrug formulation
PharmacologicalScreening-II
Value addition Marketing
Success story of JeevaniSuccess story of Jeevani
Arogyappacha
Arogyappacha naturally grows in Arogyappacha naturally grows in AgasthyamalaiAgasthyamalai
Trichopus zeylanicus Trichopus zeylanicus ssp.ssp. travancoricus travancoricus
Active principle:Active principle: 6-acetyl-7-hydroxy, 8-methoxy-2, 2-2dimethyl-3,4-dihydro-2H-1 benzopyran
The plant possesses Antistress, antihepatotoxic, immunoenhancing, anticancer and antioxidant properties
Benefit sharing: TBGRI Model
Our strength• India is one of the 17 mega biodiversity countries of
the world, with about 45,000 species of plants• About 1,000 plants are used in the Indian System of
Medicine (ISM)• Nearly 9,500 wild plant species are used by the
tribes (of these some species have direct medicinal use and some are giving new leads and claims that require scientific scrutiny)
• 3,900 have edible utility• 300 species are used as pesticides
Medicinal plants used in Ayurveda
Approximately 4645 ethnic communities of India use about 9500 plants for healthcare
Number of plants used in Ayurveda 1000
Plants having direct medicinal use 7500
New claims and leads 950
Hortus Malabaricus IndicusHortus Malabaricus Indicus
17th century publication on the
medicinal wealth of Kerala
Hendrik Adriaan van Rheede
Problems in Development and Problems in Development and Trade of Phytomedicines in IndiaTrade of Phytomedicines in India
• Depleting resources• Lack of agrotechnology standardization• Lack of qualified human resources for:
Scientific screening for bioactive moleculesGood manufacturing practice Quality control/standardizationPlanning of business and trade
Post-graduate course in Phytomedical Science and Technology
integrates traditional knowledge on natural integrates traditional knowledge on natural resources with modern science and technology to resources with modern science and technology to
make a big leap in the global market of herbal make a big leap in the global market of herbal healthcare productshealthcare products
Study focusStudy focus
• Exploration, taxonomic characterization and documentation of medicinal plant resources
• Cultivation and conservation of medicinal plants• Study of traditional knowledge on plants• Phytochemical screening for biodynamic molecules• Pharmacology and Pharmacognosy• Good manufacturing practice• IPR issues and Quality standards• Business planning and Trade
THANK YOU
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