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HPA AXIS
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The Immune System - The Players (not to scale):
neutrophilsMonocytes/macrophages
T-cells B-cells
The Defense:
The enemy:
bacteria virusVirally-infected
host cellForeign protein,carbohydrate,
lipid
Granules withdigestive enzymes
Fragment of enemy after engulfment T cell receptor
M
M interleukins
antibodies
Interleukins
Experiment - Hans Seyle
Inject:organic extract; formaldehyde;
Response:↑ size adrenals ↓ size thymus
Stimuli: crowding; noise
Response: ↑ size adrenals ↓ size thymus
does increase cortisol from adrenals cause decrease immune response (IR)?
Ex: 1
HPA AXIS
Inject: strep. Cell walls
Response:
Inject: strep cell walls
Response:
Inject 1: strep cell wall plus anti-inflammatory drug (stop CRH release from hypothalmus),
Response: rats die
Why? ________________
Inject 2: as above but then + cortisol
Response? _________
Conclusion: ______________________
Lewis Rats: susceptible to arthritis/inflammation
Fisher Rats: resistant to arthritis/inflammation
Ex: 2
++++ IR, that does not attenuate, giving rise to arthritis symptoms
normal IR, that does attenuate, no arthritis symptoms
Inject: Day 0, horse RBC
Response: Normal IR with antibody and T cell activation
Inject: then day 6, sheep RBC
Response: No IR
Why?
Conclusion:
Inject: Day 0, horse RBC
Response: normal IR
Inject: then day 6, sheep RBC
Response: normal IR
Normal mice
Adrenonectomized mice (remove adrenal glands)
Ex. 3
Inject: bacterial cell wall into belly
Response: IL1 made in brain
Inject: IL1 into belly or blood
Response: cortisol, ACTH increase
Conclusion:
Ex. 4
Inject: MS protein
Response: extensive MS symptoms
Inject: MS protein
Response?
Conclusion:
Ex. 5
First remove adrenals then protein elicit MS symptoms
+ steroid pellet implants
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