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Taylor Miller Marine Anti-Cancer Compounds. Background. Cancer still claims the lives of many 1 out of the 6 cancer treatments hinders tumor growth. What’s the deal?. Marine organisms produce anti-cancer compounds. - PowerPoint PPT Presentation
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Taylor MillerMarine Anti-Cancer Compounds
Background
• Cancer still claims the lives of many• 1 out of the 6 cancer treatments
hinders tumor growth
What’s the deal?• Marine organisms produce anti-
cancer compounds
Current status of marine natural products in anticancer preclinical or clinical trials
Compound (figure number)
Source organism Chemical class Molecular target Current status
Ecteinascidin 743 Ecteinascidia turbinate (tunicate; possible bacterial source)
Tetrahydroisoquinolone alkaloid
Tubulin Phase II
Dolastatin 10 Dolabella auricularia/Symploca sp. (mollusc/cyanobacterium)
Linear peptide Tubulin Phase II
Bryostatin 1 Bugula neritina (bryozoan)
Macrocyclic lactone PKC Phase II
Synthadotin Dolabella auricularia/Symploca sp. (synthetic analogue)
Linear peptide Tubulin Phase II
Kahalalide F Elysia rufescens/Bryopsis sp. (mollusc/green alga)
Cyclic depsipeptide Lysosomes/erbB pathway
Phase II
Oceanography• My future career• Help cure or prevent cancer
Why do you care?
• You may know someone
affected by cancer
What lies ahead?
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