TAKING OWNERSHIP OF OUTCOMES DATA...ANIMAL SENTINELS OF HUMAN DISEASE Increased sensitivity Canary...

TAKING OWNERSHIP OF OUTCOMES DATACAROLYN J HENRY, DVM, MS, DACVIM (ONCOLOGY)

UNIVERSITY OF MISSOURI COLLEGE OF VETERINARY MEDICINE

1DataConference

March 27,2019

WHAT CAN COMPANION ANIMAL DATA DO FOR US?

Impact points:

Preventative strategies

Research emphasis

Veterinary curriculum

Market identification

STRATEGIC DATA MINING

Disease surveillance

Sentinel animals

Machine learning and epidemiology

Outbreak detection and prevention

ANIMAL SENTINELS OF HUMAN DISEASE

Increased sensitivity

Canary in the coal mine

Shortened life span

Asbestos →Mesothelioma

Asymptomatic exposed

Thai dogs with H5N1 strain of avian flu

DATA SOURCES

UNIVERSITY OF WASHINGTON CENTER FOR ONE HEALTH RESEARCH

BANFIELD APPLIED RESEARCH & KNOWLEDGE (BARK)

Data from over 2.5 million dogs and 518,000 cats seen in 2017

State of Pet Health Reports define pet population and disease prevalence

Add in banfield web pic

STRATEGIC DATA MINING

Disease surveillance

Sentinel animals

Machine learning and epidemiology

Outbreak detection and prevention

Breeding programs and genetic discovery

OFA

STRATEGIC DATA MINING

Disease surveillance

Sentinel animals

Machine learning and epidemiology

Outbreak detection and prevention

Breeding programs and genetic discovery

OFA

Correlates to human disease

Translational Medicine

21

Cardiomyopathy

Degenerative disc

disease

Lymphoma

Epilepsy

18%16%

10%8% 8% 9%

6% 6% 5%

14%

Lymphoma Mast Cell

Tumor

Hemangio-

sarcoma

Osteo-

sarcoma

Mammary Other Soft

Tissue

Sarcoma

Melanoma Oral/Nasal Squamous

Cell

Carcinoma

Other*

Source: Brakke Aug 2002; Burke October 2002; Modiano Lab of the AMC Cancer Research Center; Expert interviews; team analysis

DOG CANCER INCIDENCE

Translational Medicine

Who is more likely to develop

bone cancer?→

24

ANNUAL INCIDENCE PER 100,000

65.07.06.0Stomach/Intestines

5.45.07.2Liver and Biliary

1.04.97.9Bone

12.6<1.025.0Melanoma

5.234.790.4Skin (non-melanoma)

HUMANCATDOGTUMORTYPE

CAUSES OF MORTALITY IN DOGS IN NORTH AMERICA

Breeds with highest proportion of neoplastic disease deaths

Bernese Mountain Dog

Golden Retriever

Scottish Terrier

Bouvier des Flandres

Boxer

CAUSES OF MORTALITY IN DOGS IN NORTH AMERICA

Breeds with lowest proportion of neoplastic disease deaths

Miniature Pinscher

Miniature Dachshund

Chihuahua

Pekingese

Pomeranian

REPORTED BREED ASSOCIATIONS WITH CANCER

Golden Retrievers – lymphoma, hemangiosarcoma

Bernese Mtn Dog- malignant histiocytosis; histiocytic sarcoma

Scottish Terriers – bladder cancer

German Shepherd Dogs – hemangiosarcoma; renal cystACa

Greyhounds, Rottweilers, Great Danes – osteosarcoma

Boxers and Pugs – mast cell tumors

Chow Chow – gastric carcinoma

English Springer Spaniel – breast Ca

GENETIC RESEARCH, TESTING AND BIOREPOSITORIES

STRATEGIC DATA MINING

Disease surveillance

Sentinel animals

Machine learning and epidemiology

Outbreak detection and prevention

Breeding programs and genetic discovery

OFA

Correlates to human disease

Biorepository access

BIOREPOSITORY ACCESS

STRATEGIC DATA MINING

Disease surveillance

Sentinel animals

Machine learning and epidemiology

Outbreak detection and prevention

Breeding programs and genetic discovery

OFA

Correlates to human disease

Biorepository access

Clinical trial networks

COHA

COTC - cancer

Regional

University of Minnesota

University of California, Davis

Colorado State University

University of Wisconsin

University of Missouri

Auburn University

University of Florida

North Carolina State University

University of Pennsylvania

Cornell University

Tufts University

Ohio State University

Purdue University

University of Minnesota

University of California, Davis

Colorado State University

University of Wisconsin

University of Missouri

Auburn University

University of Florida

North Carolina State University

University of Pennsylvania

Cornell University

Tufts University

Ohio State University

Purdue University

Translational Medicine

40

The KC Animal Health Corridor represents 56% of the TOTAL

WORLDWIDE animal health, diagnostics and pet food sales.

MIDWEST CLINICAL TRIALS CENTER

Veterinary School Collaboration

University of Missouri

Kansas State

Oklahoma State

Iowa State

Increased Access to Trials

Trained Coordinator

Screening Patients

Active Sponsor Solicitation

LIFETIME STUDIES IN DOGS

CHALLENGES WITH VETERINARY DATA

Multiple platforms that don’t ‘talk’ to each other

CHALLENGES WITH VETERINARY DATA

Multiple platforms that don’t ‘talk’ to each other

Silos

Quality control

Loss to follow-up

We Can Make a Good Team!