Successfully Scaling Up Industrial Fermentation of ... Lubben.pdf · Successfully Scaling Up No...

Marcel LubbenPresident, Reverdia

Successfully Scaling Up Industrial Fermentation of Biosuccinium™

Successfully Scaling UpNo technical scale-up without commercial scale-up

Create Market Pull

Create Trust

Technological scale-up

Commercial scale-up

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enabling sustainable materials

Create Trust

Technological scale-up

Utilizing the distinct and unique competencies of two leading companies

Create TrustReverdia: Powered by DSM + Roquette

• Top global starch and derivatives producer

• Biorefinery experts

• €3 billion Euros turnover

• Member of UN Global Compact

• Biotechnology leader

• Annual net sales of around €9 billion

• Top ranking Dow Jones Sustainability Index

Experts on the potential of biomass

Experts on using microorganisms to convert sugars from biomass into chemicals/materials

Biomass Biosuccinium Materials OEM Brand Owner

Low-pH yeast technology enables economic commercial production

Creating TrustSelect best technology and use through entire scale-up

Best LCASimple & robust process

Flexible feedstock(1st and 2nd generation)

Consistent QualityBest economicsLow-pH yeast technology

Select best technology and use through entire scale-up – avoid changes halfway

Large CO2 reduction potential with Biosuccinium™

Create TrustBiosuccinium™ Footprint Benchmarks

Executed by the Copernicus Institute at Utrecht University, the Netherlands

The adipic acid data is for a best in class plant with 98% N2O abatement.

Data is published in the Wiley Online Library (August 2013)

Provide consistent supply with growing production capacity

Create TrustStatus Supply Chain

• Current Biosuccinium™ capacity about 10 kta• Expansion plans for next facility of about 50 kta by 2016

Biomass Biosuccinium Materials OEM Brand Owner

Create TrustFermentation

No shortcuts in scale-up1. Pilot 2.Demo 3.First commercial

Create Trust Product Recovery

Don’t solve everything at once but stick to order:1. Quality 2.COGS 3.Productivity increase

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Create Trust

Select best technology and use through entire scale-up – avoid changes halfway

No shortcuts in scale-up– Pilot– Demo– First commercial

Don’t solve everything at once but stick to

1. Quality2. COGS & LCA – minimize side stream

production3. Productivity increase

Be on-site during start-up – seamless transfer lab -> pilot -> demo -> commercial plant – no shortcuts

Summary

Technological scale-up

Create Market

PullCommercial

scale-up

Create Market PullAssembling the Value Chain

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In-house application development Support customer application development activities Identify impact on processes and downstream products Develop demonstrator end-use products Create market pull

Create Market PullBiosuccinium™ Qualified in Multiple Applications

TPU = thermoplastic polyurethane; PU = polyurethanes; PBS = polybutylene succinate: new biopolymer; Spandex / Elastane = elastic fibers

Polyurethanes Footwear mid and outer soles:

30 % bio-based

Alkyd paint Resin: biobased from 66% to 96%

– several renewables used Coating with dimethyl succinate

solvent: – reduction drying time ~40%.– hardness developed faster

Biosuccinium™ Demonstrators Help Create Awareness and Market Pull

Create Market PullDeveloping Demonstrators

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Create Market Pull

There is no such thing as being too early for market development

Deliver additional customer benefits next to the green benefit

Work the value chain! Continuous dialogue between

– Process– Quality– Customer feedback

COGS and quality equilibrium Believe in your offering!

Summary

Create Market Pull

Commercial scale-up

Successfully Scaling UpNo technical scale-up without commercial scale-up

Create Market Pull

Create Trust

Technological scale-up

Commercial scale-up

Thank youMarcel Lubben, President email: marcel.lubben@reverdia.com

twitter: @marcellubben

www.reverdia.com