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Student Research InterestHER2 Receptor Signaling in Breast Cancer Cells
Marc Y. FinkBiomedical Sciences
LIU-Post
HER2 and Breast Cancer
• Amplification or chromosomal region 17q12• RTK of the EGFR-family• HER2 is overexpressed and induces a state in
which proliferation and survival are increased• Several drugs are approved for molecularly
tailored treatment (trastuzumab and lapatinib)• They often induce resistance after 1-2 years of
treatment
HER2 SignalingHER2
PP
PI3K
AKT
Grb2
Shc
SOS
Ras
TSC2TSC1Raf
MEK 1/2
ERK 1/2
RSK
mTORC 1
p70S6k
S6
Rheb
*
* *
PP
IGF1R
PP
FGFR
What are the intracellular targetsthat may be useful for targeting HER2-breast cancers?
How does the network reorganize after HER2 inhibition?
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