Nobel Prize in Physiology or Medicine - 1974

Nobel Prize in Physiology or Medicine - 1974For “the structure and functional organization of the cell”

Christian de Duve George E. PaladeAlbert Claude

Modern Cell Biology – Structure and FunctionA Membrane Bound Perspective

1938 - Electron microscope available

Albert Claude – Rockefeller Institute used EM for visualizing cells Invented differential centrifugation and went on to discover the endoplasmic reticulum

George Palade – Discovered ribosomes and determined that they carry out protein synthesis

Went on to show that vesicles travel from ER to golgi to outside of the cell

Christian de Duve – Used fractionation to isolate groups of enzymes discovered lysosome and perioxisome

A WELL-KNOWN TECHNIQUE FOR USING 35S OR 3H TO STUDY PROTEIN MOVEMENT

WITHIN A CELL

After 10 minutes, insulinmoves from ER to Golgi

Pulse of pancreatic B cells with 3H

After 45 minutes, the protein is found in the secretory granules

Flourescence Recovery after photobleaching (FRAP)Flourescence loss in photobleaching (FLIP) pg 608 in your book

Three main types of coated vesicles:

Clathrin is also involved in receptor mediated endocytosis

http://www.abcam.com/

BOTH Clathrin and COPI/II assembly requires GTPases

Nobel Prize in Physiology or Medicine - 1974

Documents

A Nobel Prize

EIICREI - Nobel Prize

Nobel Laureate or Nobel Prize winning organisation

The Nobel Peace Prize

nobel prize winner

The Geophysics Nobel Prize | The Mountain Mystery · 2016-08-20 · Alfred Nobel, wondering who should get this year’s Nobel Prize in Geophysics. The Geophysics Nobel Prize Posted

Nobel prize in physics

Nobel prize in medicine

NOBEL PRIZE - PEACE

MEDICINE PRIZE 2018...Illustration: Niklas Elmehed James P. Allison Tasuku Honjo THE NOBEL PRIZE NOBEL PRIZE LESSONS THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 2018 Cancer cells divide

School „nobel prize

Alfred Nobel och nobelpriset...THE NOBEL PRIZE NOBEL PRIZE LESSONS The Nobel Prize Since 1901 For the greatest benefit to humankind. Photo: Alexander Mahmoud THE NOBEL PRIZE NOBEL

The Nobel Foundation annual report 2020...the nobel prize 6 annual report 2020 The Nobel Prize The 2020 Nobel Prize laureates Since 1901, the Nobel Prize has been awarded 603 times

1979 Nobel Prize Laureate

Slideshow - Nobel Creations - Nobel Prize Lessons · THE NOBEL PRIZE NOBEL PRIZE LESSONS NOBEL CREATIONS Alfred Nobel 1833–1896 “If I have 300 ideas in a year and just one turns

Predicting RNA Structure and Function. Nobel prize 1989 Nobel prize 2009 Ribozyme Ribosome

001-032 吉武 02 - tcue.ac.jp · The ﬁ rst biography of Alfred Nobel was published in ... Key words: Alfred Bernhard Nobel, Nobel Prize, Nobel Peace Prize, Nobel Prize in Literature,

PHYSICS PRIZE 2018...THE NOBEL PRIZE NOBEL PRIZE LESSONS Physics Prize 2018 THE NOBEL PRIZE IN PHYSICS 2018 A tool for using laser light to capture and manipulate particles, …

Nobel prize 1906

Nobel Prize