View
1
Download
0
Category
Preview:
Citation preview
www.pucrs.br/feng/microg
Microgravity CentreThe Establishment of a Life Sciences Research Centre
in Brazil: Its Ups and Downs
Thais RussomanoHead, Microgravity Centre/FENG-PUCRS, Brazil
www.thaisrussomano.com
Porto Alegre - RS
Objectives
1- Projects - short duration, 1 to 6 months, since studies which last much longer tend to impair the development of a new centre;
2- Low cost projects in order to avoid financial considerations limiting research activity;
3- Motivate researchers, teachers and students from different areas (multidisciplinary research Centre);
4- Publish high quality research papers in scientific journals;
5- Act as a link between Brazil and universities and institutions in other countries by the exchange of investigators, students, equipment and joint funding for collaborative projects;
6- Contribute to Space Life Sciences with clear scientific, technological social and economic benefits for society.
MicroG Lab
The beginningFirst Phase
1999 - 2001
One project
An idea
A dream
MicroG Lab
Second Phase
2001-2006
Altitude Simulation
Aerospace Biomedical Engineering
Aerospace Pharmacy
Aviation Physiology
Aerospace Cardiopulmonary
Physiology
Telemedicine
Aerospace Biomechanics & Physiotherapy
Exchange Programs
MicroG Centre
Third Phase
September 2006
MicroG MicroG –– Room 2Room 2
International Cooperation
King´s College London, UK (MoU)University of New York, USA (MoU)Kaunas Medical University, Lithuania (MoU)Warsaw Medical University, Poland (MoU)Embry-Riddle Aeronautical Univ (MoU)Univ of Central Florida (MoU)DLR, Germany (MoU)Univ of Plymouth, UKUniv of Toronto, CanadaESA, ATC, GermanyNASA, USAGreek Aerospace Medical Association & Space Research
National CooperationBrazilian Space AgencyNational Institute of Space ResearchBrazilian Aerospace Medical AssociationPrivate Companies – Lifemed, Toth, Dental Care
HarridgeNewhamThackertPavlouGreenRowlerson
Centre of Human & Aerospace
Physiological Sciences
The Microgravity Centre
2 million dollars(maybe 1.5 million dollars more soon!!!)
PUCRS High Administration
Schools of Medicine, Engineering, Aeronautical Sciences
Microgravity Centre - Prof Thais Russomano
7 Laboratories
- Coordinator (Professor)- Trainees- Students with scholarships- Researchers
2 Research Assistants
Estimated number of people working at the MicroG = 100Number of students linked to the Micro G = 33
The Microgravity CentreA Pioneer Space Life Sciences Research Centre
in Latin America
Aerospace Biomedical Engineering Laboratory
Space Physiology Laboratory +Aviation Physiology & Medicine Laboratory(John Ernsting Aerospace Physiology Lab)
Joan Vernikos Aerospace Pharmacy Laboratory
Aerospace Physiotherapy Laboratory
Aerospace Biomechanics Laboratory
Aviation Research Laboratory
Telemedicine Laboratory
MICROGRAVITY CENTRE
Aerospace Biomedical Engineering Laboratory
MICROGRAVITY CENTRE
Aerospace Biomedical Engineering Laboratory
MICROGRAVITY CENTRE
JE Aerospace Physiology Lab
MICROGRAVITY CENTRE
JE Aerospace Physiology Lab
MICROGRAVITY CENTRE
JV Aerospace Pharmacy Lab
MICROGRAVITY CENTRE
JV Aerospace Pharmacy Laboratory
MICROGRAVITY CENTRE
Aviation Research Laboratory
MICROGRAVITY CENTRE
Aerospace Physiotherapy Laboratory
I SeminI Semináário Brasileiro de rio Brasileiro de Fisioterapia AeroespacialFisioterapia Aeroespacial
QuandoQuando: dia 25/10/2008: dia 25/10/2008OndeOnde: Hospital São Lucas da PUCRS sala : Hospital São Lucas da PUCRS sala -- IRMÃO JOSIRMÃO JOSÉÉ OTÃO OTÃO –– segundo andarsegundo andarHorHorááriorio: 08.00h : 08.00h ààs 18.00hs 18.00h
PromoPromoççãoão::Cursos de Fisioterapia do IPA/ PUCRS, Centro de Microgravidade (Cursos de Fisioterapia do IPA/ PUCRS, Centro de Microgravidade (PUCRS) e NPUCRS) e Núúcleo de Fisioterapia cleo de Fisioterapia Aeroespacial (NUFA).Aeroespacial (NUFA).
QuantoQuanto: Entrada Franca: Entrada Franca
Certificado IncluCertificado Incluíído.do.
MICROGRAVITY CENTRE
Aerospace Biomechanics Laboratory
MICROGRAVITY CENTRE
Telemedicine Laboratory
MICROGRAVITY CENTRE
Community Activities – Scientific Fairs and Exhibition
Van Gogh Project
µµG Blood CollectorG Blood Collector
µµG Blood CollectorG Blood CollectorCharacteristic Radial Artery
SampleHyperemic Earlobe
SampleDiscomfort Painful Pain Free
Potential Complications
Hematoma Hemorrhage
Infection Wrist pain
Hemorrhage Cutaneous infection
Ease of Use Requires trainedmedical personnel
Performed by non- medical personnel.
Potential Usage Hospitals research Hospitals, Private Clinics, Rural Centers,Aero medical Transport, ISS, Other space missions
µµG Blood CollectorG Blood Collector
µµG Blood CollectorG Blood Collector
µµG Blood CollectorG Blood Collector
Method of Blood Collection with EABCMethod of Blood Collection with EABC
www.pucrs.br/feng/microg
4. Analysis
1. Arterialization
2. Cleaning
3. Collection
Previous testsPrevious tests
www.pucrs.br/feng/microgwww.pucrs.br/feng/microg
Shock and vibration tests
ESA Parabolic Flight
Hypoxia
www.pucrs.br/feng/microgwww.pucrs.br/feng/microg
Procotol – Clinical Validation
A clinical validation study was performed on 12 patients with a medically determined need for measurement of arterial blood gas tensions and acid-base variables.
Every collection consisted of one blood sample taken from the arterial side of an arterial-venous fistula and one of arterialized blood from the earlobe.
Blood analyses were based on the EC8+ i-STAT® cartridge (Abbott) that measures pH, PCO2, HCO3-, BEecf, Glu, BUN, Na+, K+, Cl-, TCO2, AnGap, Hct and Hb.
After each collection, the patient was asked to complete a pain assessment scale and the earlobe incision length measured.
www.pucrs.br/feng/microgwww.pucrs.br/feng/microg
Blood Collection:
EABC versus Blood from the arterial side of the fistula
EABC Fistula
ResultsResults
www.pucrs.br/feng/microgwww.pucrs.br/feng/microg
The perceived pain was classified as minor to moderate with a
mean (±SD) of 2.7 (2.4) points (from 0 to 10).
The mean (±SD) of the earlobe cut length was 4.4 (1.3) mm.
ResultsResults
www.pucrs.br/feng/microg
The mean of the differences obtained from the arterialized and arterial samples ranged from 0.006 (for pH) to 2.8 mg/dL (for glucose).
The R2 was equal or above 0.93 in 10 of the 13 blood variables measured.
The lowest R2 was for PCO2 (0.68).
Nine of the 13 blood variables measured showed no significant difference.
BUN, Cl-, K+, anion gap were significantly different, but values varied from normality in the same direction and the difference presented has no clinical implication and affects neither treatment nor diagnosis.
www.pucrs.br/feng/microgwww.pucrs.br/feng/microg
The results indicated that the EABC usage in a clinical environment can deliver results, which represent the same physiological properties as arterial blood collected from the arterial fistula.
The EABC for the first time gives a realistic possibility for the safe and easy access to arterialized blood sampling during space missions.
Conclusion
www.pucrs.br/feng/microg
The Microgravity CentreA Pioneer Space Life Sciences Research Centre
in Latin America
Thais RussomanoHead, Microgravity Centre/FENG-PUCRS, Brazil
www.thaisrussomano.com
Recommended