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Histologi of Histologi of The Immune System The Immune System
E. A. JALAL
The Lymphoid Organs
Central/Primary lymphoid organs
Bone marrowThymus
Peripheral/Secondary lymphoid organs
Lymph nodesSpleen Mucosa-associated lymphoid
tissue (MALT)
Gut-associated lymphoid tissue (GALT)
Nasal-associated lymphoid tissue (NALT)
Bronchus-associated lymphoid tissue (BALT)
Urogenital tract and other mucosa
Bone Marrow
Thymus
Hassal corpuscle
Cortex
Medulla
Thymus
T cells development in thymus
Thymus derived lymphocytes
( T Lymphocytes)
• CD8+, CD3+ αβ TCR Naïve Cytotoxic T Cells
• CD4+, CD3+ αβ TCR Naïve Helper T Cells
• CD4+, CD25+, FOXP3+ Regulatory T Cells
• CD4+, αβ TCR NK T / Natural Killer T Cells
• CD3+, γδ TCRγδ T Cells
Lymphocytes mature in the bone marrow or the thymus,
then congregate in lymphoid tissue throughout the body
• The lymph nodes filter out antigens draining from the peripheral bodily tissues.
A lymph node
Capsula fibrosa
Cortex
Para cortex
MedullaHylus
Figure 1-8 part 1 of 2
Lymphonodules Germinal center
Afferen lymph vessel
Sinus sub capsularis
Sinus trabecularis
High Epithelial Venule
Medullary cords and sinuses
Spleen
Spleen
Spleen. Trabecula, central artery, splenic corpuscle
White pulp
Red pulp
Red pulp
Reticular fiber, spleen
The Mucosal Immune System
Mucosa-associated lymphoid tissues
MALTs
GALTs
Peyer’s patch
M cells
Lymphocytes in Lamina Propria
Waldeyer’sring
Tonsila palatina
Tonsila lingualis
Tonsila pharingea
Bronchus-associated LT
Solitary lymph node, upper resp tract
Mucosal Immune System
• IELs – Intra Epithelial
Lymphocytes• LP
– Lamina Propria Lymphocytes
• ILF– Isolated Lymphoid
Follicles• PP
– Peyer’s Patches• MLN
– Mesenteric Lymph Nodes
Mucosal Immune System
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