Gut-2012-Siddiqui-A233-4

cells stained is scored 0e5, a maximum Quick score per sample of 8.Differences in expression between HC and CD samples wereanalysed using ManneWhitney U test.Results Colonic biopsies from 20 HC and 20 CD patients werestained for NLRP3, ASC, Pyrin and Caspase-1 protein expression. Allfour proteins were expressed in HC and CD tissue. There weresignicant differences in expression of all 4 proteins when HC andcolonic CD samples were compared (Abstract PTU-116 table 1).

Abstract PTU-116 Table 1 Difference in expression of inflammasomeproteins

ProteinQuick scoreHC median (IQR)

Quick scoreCD median (IQR) p Value

NLRP3 2 (2e5) 7 (6e7.5)

data heterogeneity and the shortage of applicable studies precludesany rm conclusions being made for clinical practice. Future trialswith improved study design (including prospective data collectionand consideration of verication bias) may help to further clarify therole of MRI in the assessment and treatment response monitoring ofperianal stulas (particularly in patients with Crohns disease).

Competing interests None declared.

PTU-119 THE IMPACT OF VARIOUS FACTORS ON BONE LOSS INIBD PATIENTS TREATED WITH ORAL STEROIDS

doi:10.1136/gutjnl-2012-302514c.119

M Y Gherghab,* P Sahay. Gastroenterology, Mid Yorkshire Hospitals, Wakefield, UK

Introduction Many factors can contribute to bone loss in Inam-matory bowel disease (IBD) patients treated with oral steroids.Methods To assess the prevalence and evaluate the impact of variousfactors on bone density in IBD patients treated with oral steroids.We conducted a retrospective study on 50 patients with ulcerativecolitis (UC) and 40 patients with Crohns disease. BMD of lumbarspine and femoral neck were measured by axial dual-energy x-rayabsorpiometry scan (DEXA) in 57 patients, and that of forearm byperipheral DEXA scan in 33 patients.Results 60% of all patients (n55) had low BMD (8.8% wereosteoporotic, 51% were osteopenic). The osteoporotics werepredominantly (75%) patients with CD and were smokers. On theother hand, 63% of osteopenics had UC and 28% were smokers.Although most of males (80.7%) had low BMD (73.3% were aged

fistula assessmentof endoanal ultrasound and MRI for perianal

A diagnostic accuracy meta-analysis PTU-118

Athanasiou and R K PhillipsM R S Siddiqui, H Ashrafian, P Tozer, N Daulatzai, D Burling, A Hart, T

doi: 10.1136/gutjnl-2012-302514c.1182012 61: A233-A234 Gut

http://gut.bmj.com/content/61/Suppl_2/A233.2Updated information and services can be found at:

These include:

serviceEmail alerting

box at the top right corner of the online article. Receive free email alerts when new articles cite this article. Sign up in the

Notes

http://group.bmj.com/group/rights-licensing/permissionsTo request permissions go to:

http://journals.bmj.com/cgi/reprintformTo order reprints go to:

http://group.bmj.com/subscribe/To subscribe to BMJ go to:

group.bmj.com on June 14, 2015 - Published by http://gut.bmj.com/Downloaded from