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glucose. glucose. ATP. ATP. NMN. NMN. NMN. I. I. I. ADP. ADP. NMNAT. NMNAT. NADH. NADH. NAD. NAD. II. II. II. III. III. III. ATP. ATP. ATP. NA. NA. IV. IV. IV. H +. NAD. NAD. ATP. ATP. ADP. PARP1. PARP1. PARP1. PARP1. PARP1. PARP1. ATP. H +. NADH. - PowerPoint PPT Presentation
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glucose
pyruvate
ATP
ATPNADNADH
NAD
NA
PARP1
H+
H+
III
IIIIV
ADP ATPNAD
ADP
NADH
The role of PARP-1 in DNA-damage induced cell death(click here)
Genotoxic stress
PARP1
NMN
ATP
NMNAT
glucose
ATP
NADH
NAD
NA
PARP1
H+
H+
III
IIIIV
ADP ATP
NAD
ADP
NADH
PARP1
NMN
ATP
NMNAT
ATP
NAD
glucose
ATP
NADH
NAD
NA
PARP1
H+
H+
III
IIIIV
ADP ATP
NAD
ADP
NADH
PARP1
NMN
ATP
NMNAT
ATP
NAD
CELL NECROSIS
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