Evolutionary Considerations in Sexual Reproduction More Rotifer Strangeness

Evolutionary Considerations in Sexual Reproduction

More Rotifer Strangeness

MI615

Andrew J. PierceMicrobiology, Immunology and Molecular Genetics

Graduate Center for ToxicologyMarkey Cancer CenterUniversity of Kentucky

Reassembly of shattered chromosomes in Deinococcus radiodurans.Nature. 2006 Oct 5;443(7111):569-73. Epub 2006 Sep 27.

Zahradka K, Slade D, Bailone A, Sommer S, Averbeck D, Petranovic M, Lindner AB, Radman M.

Reassembly of shattered chromosomes in Deinococcus radiodurans.Nature. 2006 Oct 5;443(7111):569-73. Epub 2006 Sep 27.

Zahradka K, Slade D, Bailone A, Sommer S, Averbeck D, Petranovic M, Lindner AB, Radman M.

Not Idigests Red: irradiated

7000 Gy γ-IR (!)

(hours post-IR)

Figure 1

Reas

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Nat

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adm

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Reassembly of shattered chromosomes in Deinococcus radiodurans.Nature. 2006 Oct 5;443(7111):569-73. Epub 2006 Sep 27. Zahradka K, Slade D, Bailone A, Sommer S, Averbeck D, Petranovic M, Lindner AB, Radman M.

Figure 2

neg

IR

IR +

3h

IR +

3h +

UV

IR +

3h +

Brd

U

IR +

3h +

Brd

U +

UV

UV doseUV dose

Grown in BrdU Repaired in BrdU

Reas

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Nat

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2006

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Reas

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Nat

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2006

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Figure 3

NAT

IVE

DEN

ATU

RIN

GssDNA

dsDNA

Reas

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Nat

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;443

(711

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2006

Sep

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Figure 4

Extreme resistance of bdelloid rotifers to ionizing radiation.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5139-44. Epub 2008 Mar 24.Gladyshev E, Meselson M.

Fertility: producing at least one active daughterFecundity: percent hatched eggs

Dose: 140 Gy / hr

Mon

ogon

ant

Bdel

loid

Table 1

Extreme resistance of bdelloid rotifers to ionizing radiation.Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5139-44. Epub 2008 Mar 24. Gladyshev E, Meselson M.

Dose dependence of bdelloid and monogonont reproduction

ParentalReproduction

F1 Reproduction

Diamonds: DSB / MbpCircles: E. dilatata (monogonant)Squares: P. roseola (bdelloid)Triangles: A. vaga (bdelloid)

Fertility: empty symbolsFecundity: filled symbols

Figure 1

Extreme resistance of bdelloid rotifers to ionizing radiation.Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5139-44. Epub 2008 Mar 24. Gladyshev E, Meselson M.

DNA double-strand breakage by IR in A. vaga (bdelloid)

Extreme resistance of bdelloid rotifers to ionizing radiation.Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5139-44. Epub 2008 Mar 24. Gladyshev E, Meselson M.

Figure 2

Standard breakage: 5 x 10-3 breaks / Mbp / Gy

Massive horizontal gene transfer in bdelloid rotifers.

Science. 2008 May 30;320(5880):1210-3.Gladyshev EA, Meselson M, Arkhipova IR.

Massive horizontal gene transfer in bdelloid rotifers.Science. 2008 May 30;320(5880):1210-3. Gladyshev EA, Meselson M, Arkhipova IR.

Massive horizontal gene transfer in bdelloid rotifers.Science. 2008 May 30;320(5880):1210-3. Gladyshev EA, Meselson M, Arkhipova IR.

Mas

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Mas

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