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REFERENSI
1. Runtuwene T, Penyakit Meniere. Dalam Joesoef AA, Kusumastuti K editor. Neuro-otologi Klinis
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Meniere's Disease (MD) is an affection consisting of an association of sensorineural hearing
loss, tinnitus and vertigo initially presenting by crises. A review of the most considered possible
causative factors and pathophysiologic interpretations allows us to underline the uncertainties
which still exist about the genesis of this illness. We propose a mechanistic model based on the
effect of a haemodynamic imbalance leading to transient ischaemia which could have an effect
on the pH of the inner ear as well as on the work of the inner ear proton pumps. It is
hypothesized that under ischaemic conditions and consequent metabolic acidity a preserved
proton pump activity can generate an overload of anions in the endolymphatic partition, which
is a closed system, thus resulting in an enhancement of osmolarity and consequently in the
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formation of a hydrops resulting in the development of fluctuating hearing loss, tinnitus and
vertigo which characterize Meniere's Disease.
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