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CSG TropMed
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Course Study Guide
Course Descriptionand
General Learning Objectives1. Course DescriptionThe course of tropical medicine system is a portion of Biomedical Program of School of Medicine Universitas Padjadjaran that covers the most common tropical and environmental diseases and it's essential clinical, behavioral and community aspects.2. General Learning ObjectivesAt the end of the course the student will be able to explain the characteristics etiology, epidemiology, Pathogenesis, clinical and laboratory findings, complications and preventions, and to analyse the principles of diagnosis and management of treatment of the most common tropical diseases.Besides that, the students are expected to be competent in performing basic clinical skills pertinent to the cases and show proper attitude.
TABLE OF CONTENTCourse Description and General Learning Objectivesi
Weekly Schedule of Tropical Medicine Systemii
Organization of Tropical Medicine System iii
1.Bacterial Infections1
2.Mycobacterial Infections5
3.Viral Infections6
4.Fungal Infections11
5.Parasitic Infections13
6.Zoonosis18
7.Environmental and Tropical Pathology19
References22
COURSE STUDY GUIDE
NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE
PERSONREFERENCES
1.Bacterial Infections1.1. Bacterial sepsis
1.2. Typhoid fever
The learner will be able (TLWBA) to : explain the definition of bacterial sepsis explain etiology of bacterial sepsis discuss epidemiology of bacterial sepsis
describe pathogenesis of bacterial sepsis
describe the mechanisms how the bacteria cause sepsis explain the clinical manifestation of bacterial sepsis
explain laboratory findings of bacterial sepsis
analyse principle diagnosis and the differential diagnosis of bacterial sepsis
analyse the management therapy of bacterial sepsis explain complications and prevention of bacterial sepsis
TLWBA to : explain general features of the walls of the intestine and gall bladder
explain agent of the etiology of typhoid fever describe morphology, structure and characteristics of bacteria that cause typhoid fever discuss epidemiology of typhoid fever
describe pathogenesis of typhoid fever
explain clinical manifestation of typhoid fever describe the specimen for laboratory examinations and laboratory methods to diagnose the disease explain laboratory finding of typhoid fever
analyze diagnosis and differential diagnosis of typhoid fever
analyze therapy of typhoid fever including mechanism of action and resistance, pharmacokinetic, indication, side effects as well as contraindication, preparation and route of drug administration of antimicrobial agents in typhoid fever.
explain complication and prevention of typhoid fever Explain thypoid toxic as complication of thypoid fever (signs & symptom of thypoid toxic and its management).5 : 147-16010 :193-2012 : 842-850
5 : 248-2618 : 849-863
10 : 323-33813 : 970-975
1NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE
PERSONREFERENCES
1.3. Diphteria
1.4. Tetanus
TLWBA to :
define the etiologic agent of diphteria
describe morphology, structure, characteristics and the mechanisms of bacteria cause the disease discuss epidemiology of diphteria
describe pathogenesis of diphteria
explain the clinical manifestations of diphteria
describe the proper specimen collection, and laboratory methods for isolation and identification of bacteria analyse principle diagnosis and the differential diagnosis of diphteria
analyse the management therapy of diphteria
explain the complications of diphteria
explain the preventions of diphteria
TLWBA to :
define the etiologic agent of tetanus
describe morphology, structure, characteristics and the mechanisms of bacteria cause the disease discuss epidemiology of tetanus
describe pathogenesis of tetanus
explain the clinical manifestations of tetanus
describe laboratory methods for isolation and identification of bacteria
analyse principle diagnosis and the differential diagnosis of tetanus
analyse the management therapy of tetanus
explain the complications of tetanus
explain the preventions of tetanus2 : 817-820
5 : 212-21810 : 279-2852 : 878-8815 : 205-2118 : 1119-1124
10 : 401-414
2NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE
PERSONREFERENCES
1.5.Pertusis1.6.Meningitis
TLWBA to :
define the etiologic agent of Pertusis
describe morphology, structure, characteristics and the mechanisms of bacteria cause the disease discuss epidemiology of Pertusis
describe pathogenesis of Pertusis
explain the clinical manifestations of Pertusis
describe laboratory methods for isolation and identification of bacteria analyse principle diagnosis and the differential diagnosis of Pertusis
analyse the management therapy of Pertusis
explain the complications of Pertusis
explain the preventions of PertusisTLWBA to :
explain the structure and function of blood brain barrier
describe the structure and function of meningens
explain the circulation of cerebrospinal fluids
define the etiologic agent of meningitis
describe morphology, structure, characteristics and the mechanisms of bacteria, fungi and viruses cause the disease discuss epidemiology of meningitis describe pathogenesis of meningitis explain the clinical manifestations of meningitis describe laboratory methods for identification causative agents analyse principle diagnosis and the differential diagnosis of meningitis analyse the management therapy of meningitis explain the complications of meningitis and its therapy
explain the preventions of meningitis
2 : 838-8425 : 282-28410 : 377-3825 : 279-282, 295-304, 734-73510 : 311-322, 367-376, 697-706
3NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
1.7. Bacterial skin infection (BSI)1.impetigo2.follikulitis
3.furunkel
4.carbuncel
5.erysipelas
6.selulitis1.8. Anaerobic
Bacteria infections
TLWBA to :
explain the layers of skin
define the etiologic agent of BSI
describe morphology, structure, characteristics and the mechanisms of bacteria that cause the disease discuss the epidemiology of BSI
describe the pathogenesis of BSI
explain the clinical manifestations of BSI
describe laboratory methods for isolation and identification of bacteria analyse principle diagnosis and the differential diagnosis of BSI
analyse the management therapy of BSI including mechanism of action, indication, side effects as well as contraindication of antimicrobial agents in BSI.
explain the complications of BSI explain the preventions of BSITLWBA to :
Define morphology, structure, characteristics and the mechanisms of infection anaerobic bacteria discuss epidemiology of Anaerobic bacteria
describe pathogenesis of Anaerobic bacteria
explain the clinical manifestations of Anaerobic bacteria
explain the laboratory findings which can be found on anaerobic bacteria patient
analyse principle diagnosis and the differential diagnosis of Anaerobic bacteria analyse the management therapy of Anaerobic bacteria
explain the complications of Anaerobic bacteria
explain the preventions of Anaerobic bacteria
1 : 251-2955 : 223-230, 231-24710 :221-25814 : 1856-18775 : 305-31110 :401-426
4NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE
PERSONREFERENCES
2.
Myco-
bacterial Infections
2.1. Leprosy2.2. Cutaneous tuberculosis (Scroffuloderma, cutaneus tuberculosis, verrucosa lupus vulgaris)
TLWBA to :
explain the layer of skin define the etiologic agent of leprosy
describe morphology, structure, characteristics and the mechanisms of bacteria that cause the disease discuss epidemiology of leprosy
describe pathogenesis of leprosy
explain the clinical manifestations of leprosy
describe the proper specimen collection, and laboratory methods for diagnose the disease analyse principle diagnosis and the differential diagnosis of leprosy
analyse the management therapy of leprosy including mechanism of action and resistance ,side effects as well as contraindication of drugs in leprosy.
explain the complications of leprosy explain the preventions of leprosy explain the prevention of disability hang function (rehabilitation)
TLWBA to :
define the etiologic agent of cutaneous tbc
describe morphology, structure, characteristics and the mechanisms of bacteria that cause the disease discuss epidemiology of cutaneous tbc
describe pathogenesis of cutaneous tbc
explain the clinical manifestations of cutaneous tbc
describe the proper specimen collection, and laboratory methods for isolation and identification of bacteria analyse principle diagnosis and the differential diagnosis of cutaneous tbc analyse the management therapy of cutaneous tbc
explain the complications of cutaneous tbc
explain the preventions of cutaneous tbc 1 :343-3525 : 328-32910 :297-31014 : 1972-19801 : 333-3422 : 1092-1093,
839-840
5 : 319-330
8 : 765-772
10 : 297-31014 : 1933-1949
5NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
3.Viral Infections3.1. Dengue virus
infection
3.2.Varicella zoster (VZ) virus Infection
TLWBA to :
explain the structure, function and percentage of each of the formed elements in blood
describe in sequence the events of blood formation including the role of the platelets describe taxonomy, classification, morphology, structure, characteristics and replication of dengue virus discuss epidemiology of dengue virus infection
describe pathogenesis of dengue virus infection
explain the clinical manifestations of dengue virus infection
describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of dengue virus infection
analyse the management therapy of dengue virus infection
explain the complications of dengue virus infection
explain the preventions of dengue virus infection, report the case TLWBA to :
describe taxonomy, classification, morphology, structure, characteristics and replication of varicella-zoster virus discuss epidemiology of varicella-zoster virus infection
describe pathogenesis of varicella-zoster virus infection
explain the clinical manifestations of varicella-zoster virus infection
describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of varicellazoster virus infection
analyse the management therapy of varicella-zoster virus infection
explain the complications of varicella-zoster virus infection
explain the preventions of varicella-zoster virus infection1 : 473-491
2 : 973-977
5 : 526-52710 : 637-64914 : 2070-20851 : 376-3842 : 856-9595 : 429-44110 : 541-55314 : 2059-2069
6NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
3.3. Poliomyelitis
3.4. Measles
3.5. Mumps
TLWBA to :
define the etiologic agent of Poliomyelitis (wild type polio virus) describe taxonomy, classification, morphology, structure, characteristics and replication of polio virus discuss epidemiology of Poliomyelitis
describe pathogenesis of Poliomyelitis
explain the clinical manifestations of Poliomyelitis
describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of Poliomyelitis
analyse the management therapy of Poliomyelitis
explain the complications of Poliomyelitis
explain the preventions of Poliomyelitis explain the prevention of disability walking ability (rehabilitation)
TLWBA to :
describe taxonomy, classification, morphology, structure, characteristics and replication of measles virus
discuss epidemiology of measles
describe pathogenesis of measles
explain the clinical manifestations of measles
describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of measles
analyse the management therapy of measles explain the complications of measles
explain the preventions of measlesTLWBA to :
describe taxonomy, classification, morphology, structure, characteristics and replication of varicella-zoster virus discuss epidemiology of mumps
describe pathogenesis of mumps
explain the clinical manifestations of mumps
describe laboratory examinations to diagnose the disease
analyse principle diagnosis and the differential diagnosis of mumps
analyse the management therapy of mumps
explain the complications of mumps
explain the preventions of mumps2 : 946-9515 : 487-49310 : 579-5902 : 954-9555 : 562-56410 : 597-6035 : 550-56110: 604-606
NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
3.6. Rubella
3.7. Molluscum
contagiosum3.8. Verruca vulgaris
TLWBA to :
describe taxonomy, classification, morphology, structure, characteristics and replication of rubella virus discuss epidemiology of rubella
describe pathogenesis of rubella
explain the clinical manifestations of rubella
describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of rubella
analyse the management therapy of rubella
explain the complications and preventions of rubellaTLWBA to :
describe taxonomy, classification, morphology, structure, characteristics and replication of molluscum contagiosum virus discuss epidemiology of molluscum contagiosum
describe pathogenesis of molluscum contagiosum
explain the clinical manifestations of molluscum contagiosum
explain the laboratory findings which can be found on molluscum contagiosum patient
analyse principle diagnosis and the differential diagnosis of molluscum contagiosum
analyse the management therapy of molluscum contagiosum
explain the complications and preventions of molluscum contagiosumTLWBA to :
define the etiologic agent of verruca vulgaris
describe taxonomy, classification, morphology, structure, characteristics and replication of virus that cause the disease discuss epidemiology of verruca vulgaris
describe pathogenesis of verruca vulgaris
explain the clinical manifestations of verruca vulgaris
describe laboratory examinations to diagnose the disease analyse principle diagnosis and the differential diagnosis of verruca vulgaris analyse the management therapy of verruca vulgaris
explain the complications and preventions of verruca vulgaris2 : 951-953
5 : 566-56910 : 645-6491 :394-3975 : 463-46410 : 565-5715 : 599-60010 : 523-528
10NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
4.Fungal Infections4.1. Histoplasmosis
4.2. Candidiasis
cutis and unguiumTLWBA to :
explain taxonomy, classification, morphology, structure, growth and reproduction of fungi and yeasts that caused histoplasmosis discuss epidemiology of histoplasmosis
describe pathogenesis of histoplasmosis
explain the clinical manifestations of histoplasmosis
describe cultivation and laboratory examination of fungi analyse principle diagnosis and the differential diagnosis of histoplasmosis
analyse the management therapy of histoplasmosis
explain the complications and preventions of histoplasmosisTLWBA to :
define the etiologic agent of candidiasis cutis and unguium
explain taxonomy, classification, morphology, structure, growth and reproduction of fungi and yeasts that caused superficial, cutaneous and subcutaneous mycosis discuss epidemiology of candidiasis cutis and unguium
describe pathogenesis of candidiasis cutis and unguium
explain the clinical manifestations of candidiasis cutis and unguium
describe cultivation and laboratory examination of fungal infections analyse principle diagnosis and the differential diagnosis of candidiasis cutis and unguium
analyse the management therapy of candidiasis cutis and unguium including mechanism of action ,side effects as well as contraindication of drugs in candidiasis cutis and unguium
explain the complications of candidiasis cutis and unguium
explain the preventions of candidiasis cutis and unguium1 : 297-3145 : 640-64210 : 772-77514 : 1989- 2006
5 : 645-64710 : 779-787
11NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
5.3. AscariasisTLWBA to :
define agent, form and characteristic of the etiology of ascariasis
discuss epidemiology of ascariasis
describe pathogenesis of ascariasis
explain the clinical manifestations of ascariasis
explain the laboratory findings which can be found on ascariasis patient
analyse principle diagnosis and the differential diagnosis of ascariasis
analyse the management therapy of ascariasis including mechanism of action, side effects as well as contraindication of agents in ascariasis
explain the complications of ascariasis
explain the preventions of ascariasis.
2 : 1064-1065
8 : 1374-1381
14
NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
5.4. Hookworm
Infections
(Necator
americanus)
5.5. EnterobiasisTLWBA to :
define agent, form and characteristic of the etiology of hookworm Infection
discuss epidemiology of hookworm Infection describe pathogenesis of hookworm Infection
explain the clinical manifestations of hookworm Infection
explain the laboratory findings which can be found on hookworm Infection patient
analyse principle diagnosis and the differential diagnosis of hookworm Infection
analyse the management therapy of hookworm Infection
explain the complications of hookworm Infection
explain the preventions of hookworm Infection
TLWBA to :
define agent, form and characteristic of the etiology of enterobiasis
discuss epidemiology of enterobiasis
describe pathogenesis of enterobiasis
explain the clinical manifestations of enterobiasis
explain the laboratory findings which can be found on enterobiasis patient
analyse principle diagnosis and the differential diagnosis of enterobiasis
analyse the management therapy of enterobiasis
explain the complications of enterobiasis
explain the preventions of enterobiasis
2 : 1065-1066
2 : 1067-1068
15NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
5.6. Trichuriasis
TLWBA to :
define agent, form and characteristic of the etiology of trichuriasis
discuss epidemiology of trichuriasis
describe pathogenesis of trichuriasis
explain the clinical manifestations of trichuriasis
explain the laboratory findings which can be found on trichuriasis patient
analyse principle diagnosis and the differential diagnosis of trichuriasis
analyse the management therapy of trichuriasis
explain the complications of trichuriasis
explain the preventions of trichuriasis
2 :1073
8 : 1372-1374
16NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
5.8. Scabies and
Pediculosis
5.9. Larvae
migransTLWBA to :
explain the layer of skin
define agent, form and characteristic of the etiology of scabies and pediculosis
discuss epidemiology of scabies and pediculosis
describe pathogenesis of scabies and pediculosis
explain the clinical manifestations of scabies and pediculosis
explain the laboratory findings which can be found on scabies and pediculosis patient
analyse principle diagnosis and the differential diagnosis of scabies and pediculosis
analyse the management therapy of scabies and pediculosis including mechanism of action, side effects as well as contraindication, preparation and route of drug administration of agents in scabies and pediculosis.
explain the complications of scabies and pediculosis
explain the preventions of scabies and pediculosis
TLWBA to :
define agent, form and characteristic of the etiology of larvae migrans
discuss epidemiology of larvae migrans
describe pathogenesis of larvae migrans
explain the clinical manifestations of larvae migrans
explain the laboratory findings which can be found on larvae migrans patient
analyse principle diagnosis and the differential diagnosis of larvae migrans
analyse the management therapy of larvae migrans
explain the complications of larvae migrans
explain the preventions of larvae migrans
1 :
3 :
4 :
6 :
11 :
15 :
1 :4 :
15 :
17NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
6.Zoonosis6.1. Leptospirosis
6.2. AnthraxTLWBA to :
define the etiologic agent of leptospirosis describe morphology, structure and characteristics of bacteria that cause leptospirosis discuss epidemiology of leptospirosis
describe pathogenesis of leptospirosis
explain the clinical manifestations of leptospirosis
explain the laboratory findings which can be found on leptospirosis patient
analyse principle diagnosis and the differential diagnosis of leptospirosis
analyse the management therapy of leptospirosis
explain the complications of leptospirosis
explain the preventions of leptospirosis
TLWBA to :
definethe etiologic agent of anthrax describe morphology, structure and characteristics of bacteria that cause anthrax discuss epidemiology of anthrax
describe pathogenesis of anthrax
explain the clinical manifestations of anthrax
explain the laboratory findings which can be found on anthrax patient
analyse principle diagnosis and the differential diagnosis of anthrax
analyse the management therapy of anthrax
explain the complications of anthrax
explain the preventions of anthrax
5 : 338-3408 : 963-970
10 : 438 - 44113 : 1055-10575 : 202-20410 : 265 - 271
NS
18NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
7.Environmental Pathology and diseases
7.1. Environtmental
pollution
-outdoor air pollution
-indoor air pollution
-industrial exposures
7.2. Pneumoconiosis
7.3. Sillicosis7.4. Asbestosis
TLWBA to
describe major outdoor air pollutants, origins and consequences
describe pattern of lung injury related to air pollutions
describe health effect of indoor air pollutans
describe human diseases associated with occupational exposures
describe human diseases associated with toxic and carcinogenic metals
describe pathogenesis of pneumoconioses, coal worker pneumoconiosis (CWP)
describe the morphology of pulmonary anthracosis, simple CWP, Caplan Syndrome
explain clinical course of CWP
describe definition and epidemiology of sillicosis
describe classification of sillicosis acording to intensity of exposure
describe morphology of sillicosis
explain the clinical course of sillicosis
describe definition and epidemiology of asbestosis
describe pathogenesis of asbestosis
describe morphology of asbestosis
explain the clinical course of asbestosis
7 : 265-290
19NOTOPICSUBTOPICSPECIFIC LEARNING OBJECTIVERESOURCE PERSONREFERENCES
7.6. Injury by chemical agent
injury by therapeutic agents
( adverse drugs reactions)
injury by nontherapeutic toxic agents
- injury by physical
agents-electrical injury
- injury produced by
ionizing radiation
-Describe the mechanisms of chemical injury
-Describe some common adverse drug reactions and their agents
-Describe adverse effects of
-estrogen therapy and oral contraceptive
-acetaminophen
-acetosal (acetylsalicylic acid )
-Describe some common nontherapeutic toxic agents and major associated pathologic effects
-describe pathogenesis and morphology of
-lead poisoning
-carbon monoxide
-alcohol and drug abuse ( ethanol, cocaine,heroin, marijuana and other illicit drugs.
-describe injury induced by physical agents .
-describe morphology of abrasion, contusion, laceration, incised wound, and puncture wound.
-describe morphology of thermal burns, hyperthermia and hypothermia.
-describe morphology and effects of electrical injury
-describe the biologic effects of radiation
20 List of References :NOREFERENCES
1.Arnold HL, Odom RB, James WD. Andrews Disease of the Skin. Clinical Dermatology, WB Saunders Co., Philadelphia,1990
2.Behrman RE, Kliegman RM and Jenson HB (eds) Nelson Textbook of Pediatric, 17th ed., WB Saunders Co., Philadelphia, 2003.
3.DepKes. RI. Tata Laksana Malaria.
4.Garcia LS, Bruckner DA, Diagnostic Medical Parasitology, 3rd Edition, ASM Press Washington DC,1997
5.Geo F Brooks, JS Butel , SA Morse. Jawetz, Melnick & Adelbergs Medical Microbiology, 23rd edition, Lange Medical Books/Mc-Graw-Hill, 2003
6.Katzung B.G. Basic and Clinical Pharmacology. 10th. Ed. 2007
7.Kumar V, Cotran RS, Robbins SL, Robbins Basic Pathology, 7th Ed, Saunders, 2003
8.Mansons Tropical Disease 21st ed. WB Saunders, 2003.
9.Natadisastra D., Parasitologi Klinik Ditinjau dari Organ Tubuh Yang diserang.
10.Patrick R Muray, Ken S. Rosenthal, Michael A. Pfaller, Medical Microbiology. 5th Ed. Elsevier Mosby, 2005
11.Junquieira LC.,Carneiro J.,O Kelley R.Basic Histology,Appleton & Lange,2005
12.WHO, Dengue Haemorhagic Fever, Diagnosis, preventive and Treatment. 1997
13.Harisons Principles of internal medicine, 15 th ed. Mc Graw Hill. 2001
14.Freedberg IM, Eisen AZ, Wolff K, Austen KF, Fitzpatricks Dermatology in General Medicine, 6 th. Ed., Mc Graw- Hill Inc., New York, 2003
15.Judith S, Heclan, Frances WI., Essentials of Human Parasitology
16.Current Diagnosis and Treatment in Infectious Diseases. 1 st Ed., International Edition : McGraw-Hill , 2001
17.Gartner L.P., Hiati J.L., Histology: 2001
21
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