Copyright Compumedics Ltd. Basics of Polysomnography (PSG) Testing /09 Basics of Polysomnography...

Copyright Compumedics Ltd.Basics of Polysomnography (PSG) Testing /09

Basics of Polysomnography

(PSG) Testing

The following presentation is being provided for informational and educational purposes only. While Compumedics endeavors to ensure the validity and accuracy of the information within, we cannot be held responsible for inaccuracies, opinions or practices that often vary between various experts or are without established acceptable medical standards. Please consult your own medical director for clarification or for policies that are specific to your facility.

We welcome your comments, suggestions and corrections. Please e-mail your comments to: marketing@compumedics.com.au

Why Perform Sleep Studies?

Quantify sleep pattern Determine cause of excess daytime sleepiness Initialize and evaluate treatment Evaluate treatment effectiveness

Types of sleep studies Diagnostic - investigative study to determine if there are

identifiable problems with the patient’s sleep CPAP titration - once a patient is identified as having sleep

apnea, another study is performed in which the technician adjusts the CPAP/BiPAP level during the test and decides which mask and type of treatment is best

Split Night - combines a diagnostic study and a titration study into one night. The patient is diagnosed during the first half of the night; CPAP/BiPAP applied the second half if required by protocol

MSLT - Multiple Sleep Latency Test (nap study) MWT – Maintenance of Wakefulness Test

Diagnostic Sleep Studies – Variables Evaluated

Sleep staging• Wake, NREM (N1,N2,N3), REM• Arousals

Respiratory• Apneas and hypopneas• Upper airway resistance

Limb EMG• PLMS• Restless legs

Polysomnography (PSG)

EEG F4-M1, EEG C4-M1, EEG O2-M1, EOG-L(E1), EOG-R(E2), EMG (chin)

AIRFLOW, both Thermal and Nasal Pressure THOR EFFORT, ABDO EFFORT SpO2, ECG, LEG(L), LEG(R) SOUND, POSITION CPAP pressure and flow Optional: additional EEG, dB meters, temperature, blood pressure

Typical Montage

Typical Polysomnogram

Sleep Architecture

Normal? Deficient in REM? Contain supine REM? Deficient in Delta sleep? Fragmented or disrupted by frequent arousals?

Normal Sleep Architecture Entered through NREM Approximately 90 minute cycle including NREM and

REM Slow wave dominates first third of night REM sleep dominates last third of night REM sleep: 20-25% total sleep time

Examples - Sleep Hynograms

Normal Sleep Architecture

No Delta (Restorative) Sleep

Severely Fragmented Sleep

Sleep Staging Variables Electroencephalogram (EEG) - acquired by surface

electrodes on the scalp at standardized locations (10-20 system)

Electrooculogram (EOG) - acquired by surface electrodes placed at the outer canthus of each eye

Electromyogram (EMG) - acquired by surface electrodes placed on the chin muscle (sub-mental)

Sleep Staging Channels

Frequency and amplitude change with sleep stage:• Wake: high frequency• Stage N1 and REM: low amplitude, mixed frequency• Stage N2: spindles, K-complexes• Stage N3: delta waves (slow frequency, high amplitude)• Standard sleep epoch is 30 seconds (10 mm/sec paper

speed)

10-20 EEG Locations

EEG Electrode Placement

Sleep Stage Criteria Awake

• Alpha or faster > 50% of epoch• Many eye movements• High EMG

Stage N1• Alpha or faster < 50 % of epoch• Increasing theta activity• Slow rolling eyes• Vertex waves

ALPHA WAVESALPHA WAVES

THETA WAVESTHETA WAVES

VERTEX WAVEVERTEX WAVE

Sleep Staging Criteria Stage N2

Sleep spindles or K-complexes

Stage N3Delta-H > 20% of epoch

(≤ 2 Hz, ≥ 75uV)

Sleep Staging Criteria REM

• Lowest EMG• Rapid Eye Movements

• Saw-tooth EEG• Low-amplitude, mixed

frequency EEG similar to stage 1

EOG EOG records voltage changes caused by eye movement EOG changes with sleep stage Wake: random, high amplitude

Stage 1: slow rolling

REM: very flat with occasional Rapid Eye Movements

EOG Electrode Placement

EMG Recorded as the potential between two surface

electrodes placed several centimeters apart Typically, the chin (submental) muscle is used

because it exhibits large differences during sleep, aiding in the identification of stages

Wake - high activity Sleep - lower activity REM sleep - paralysis of skeletal muscles

EMG Placement

Submental (chin) AASM placement =

one midline and two under the chin

Stage N1 Sleep

Stage N2 Sleep

Stage N3 Sleep

Stage REM Sleep

Respiratory variables Respiratory effort (thoracic and abdominal) Airflow (thermistor, thermocouple, nasal pressure,

ETCO2) SpO2 Snoring sounds Optional signals

• ETCO2• tcCO2

Airflow Used for detecting respiratory events

• Apnea: no airflow• Hypopnea: reduced airflow

How is airflow commonly measured?• Temperature changes: thermistor/thermocouple – used

for apnea detection• In/ex pressure changes: nasal cannula – used for

hypopnea detection• ETCO2 – most often used in pediatrics

Respiratory Effort

Used for classifying respiratory events

e.g. Apnea: no airflow but effort indicates obstruction Inductive plethysmography bands – AASM Piezo-electric bands EMG: diaphragm/intercostal Esophageal pressure

Other Respiratory Variables

Gases: SpO2 – Blood oxygen level (%) by oximetry tcCO2 – Transcutaneous CO2 etCO2 – End Tidal CO2 Arterial CO2 – blood analysis

Other Variables Typically Recorded

ECG Leg movement: EMG (AASM), piezoelectric Video Body position CPAP flow and pressure (DC input)

Respiratory Events Apneas

• Obstructive• Central• Mixed

Hypopneas Respiratory Event Related Arousals - RERA

• Respiratory event does not meet the criteria for event types above

• Causes a disruption of the sleep architecture (arousal)

Obstructive Apnea

Cessation of airflow for more than 10 seconds

With abdominal and/or thoracic effort Usually terminated by an arousal and/or

associated with a desaturation

Example - Obstructive Apnea

Central Apnea

Cessation of airflow, usually for more than 10 seconds

Without abdominal and/or thoracic effort May be terminated by an arousal and/or

associated with a desaturation Very different type syndrome than OSA; chemo-

receptor irregularities

Example - Central Apnea

Mixed Apnea Cessation of airflow >10 s (in adults) with

respiratory effort Contains both central and obstructive

components, with each component lasting at least one normal respiratory cycle

Typically leads to a desaturation and an arousal

Is really just a type of obstructive event with the same consequences

Example - Mixed Apnea

Hypopnea

Nasal Pressure signal amplitude drop by ≥ 30%

Duration of at least 10 seconds ≥ 4 % desaturation 90% of event meets amplitude reduction

criteria

Hypopnea - Alternative

Nasal Pressure signal amplitude drop by ≥ 50%

Duration of at least 10 seconds ≥ 3 % desaturation or an associated arousal 90% of event meets amplitude reduction

criteria

Example - Hypopnea

Repetitive (at least 4) episodes of muscle contraction (0.5-10 s duration)

Minimum amplitude increase of 8 uV above baseline Separated by > 5 seconds, but not more than 90

seconds Arousals sometimes associated with the movements Positive diagnosis if more than 5 per hour of sleep Movements may be clinically significant only if

associated with arousals

Example - PLMS

Arousals

Abrupt shift of EEG frequency Lasts at least 3 seconds At least 10 seconds of prior stable sleep During REM requires concurrent increase in

chin EMG lasting at least one second

Example – REM Arousal

Normal sinus rhythm? Bradycardia or Tachycardia? Frequent atrial/ventricular arrhythmias?

Run of 5 or more ventricular arrhythmias?

ECG – AASM Reporting Average heart rate during sleep Highest HR during recording/sleep Bradycardia < 40 bpm (lowest observed) Sinus Tachycardia > 90 bpm (highest observed) Narrow Complex Tachycardia (highest observed) Wide complex Tachycardia (highest observed) Asystole, longest pause Atrial fibrillation List other arrhythmias

Basic Steps to Analyze a Study Using Compumedics Software

1. Automatic Analysis– Sleep Staging – Arousal Scoring– Respiratory Scoring– PLM Scoring

2. Manual Editing– Validate Sleep Staging– Event Editing: Respiratory, PLM, and ECG– Arousal Classification and editing

3. Reporting4. Archiving

Sleep architecture

• What was the sleep efficiency?• What was the percent of each stage of

sleep?• What was the sleep onset time?• What was the REM onset time?

Respiratory Events Which events were most common? Were there any obstructive events? What was the AHI (Apnea/Hypopnea Index)? What was the RDI (Respiratory Disturbance

Index) Apnea + Hypopnea + RERA per hour of sleep

What was the nadir and baseline SpO2? Was any snoring recorded?

Leg Movements

Were they periodic? What was the index (number per hour of

sleep) Did they cause arousals?

Arousals

How many per hour? Related to events??

• Respiratory events• Leg movements• Esophageal reflux• Seizures• Unknown (spontaneous)

CPAP/BiPAP

Effective? Best pressure? Best mask? Tolerance?

Generate report Write results summary Save Print Print raw data examples Add doctors summary File and send to referring

doctors

Reporting Sleep Studies

Copyright Compumedics Ltd. Basics of Polysomnography (PSG) Testing /09 Basics of Polysomnography...

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