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CLINICAL SUMMARY
EXPOSURE OATE: AGE AT EXPOSURE: ) DEATH DATE:
���S A;O������OSURE: 1f!f3
TATIOO= .:t-sioC BIRTHOAT� : ?qlo 9-SEX: M �() 4 I I" SIRE: 1 ,/ ,1,.1_ l10 '--OAM: 1 ""f, -,:"> sruo C J_ YY\ICt(_ fyt'f!c r;{)0
GROSS NECROPSY NOTES
I. ANIMAL IDENTIFICATION:
A. TATOO NUMBER: 1546C
B. SPECIES: Canine
C. DATE OF BIRTH: 69162
D. SEX: Male
E. TITLE OF EXPERIMENT: Mech. of Rad.-Induced Cancer
F, PATHOLOGY SERIES INDEX NUMBER: DA-040
G. EXPERIEMTN NUMBER: 5272
H. DATE OF EXPOSURE: 91242
II. HISTORY:
A. MODE OF DEATH (EUTH., SAC., DIED): Sacrificed
B. DATE AND TIME OF DEATH: 91325 (11/21/91) 7:45
C. DATE AND TIME OF NECROPSY: 91325 (11/21/91) 6:00 a.m.
D. AGE AT DEATH: 673 Days
E. DAYS AFTER EXPOSURE: 63 Days
F. CLINICAL SUMMARY:
Scheduled sacrifice.
II. PROSECTORS: C. Maruszak, K. Garcia
IV. PATHOLOGIST IN CHARGE: Dr. Kris J. Niku1a
V. EXTERNAL APPEARANCE:
A. TOTAL BODY WEIGHT AT NECROPSY: 7.3 kg
B. PHYSICAL CONDITION: Excellent
C. POSTMORTEM CONDITION: Excellent
D. MUCOUS MEMBRANES: NGL (No Gross Lesions)
E. BODY OPENINGS: NGL
F. EXTERNAL GENITALIA: NGL
G. SKIN: NGL
H. SUBCUTIS: NGL
I . MAMMARY GLANDS : NGL
VI. CAVITARY FINDINGS:
A. THORACIC: NGL
B. ABDOMINAL: NGL
VII. RESPIRATORY SYSTEM:
A. NASAL CAVITY: NGL
B. PARANASAL SINUSES: NGL
C. LARYNX: NGL
D. TRACHEA: NGL
E. LUNG: 54.81 g (total weight) -
There were fibrous adhesions between the RD and RI lobes
and between the LAC and LD lobes. The lungs had a slight grey
discoloration.
F. MEDIASTINUM: NGL
VIII. CARDIOVASCULAR SYSTEM:
IX.
X.
A. HEART:
Total Heart: -
Left Ventricle and Septum: -
Right Ventricle: -
Right AV Valve: 7.9 em
Left AV Valve: 6.5 em
Pulmonary Valve: 3.1 em
Aortic Valve: 3.7 em
Left Ventricular Myocardium: 1.1 em
Right Ventricular Myocardium: 0.3 em -
NGL
B. PERICARDIUM: NGL
C. MAJOR VESSELS: NGL
ALIMENTARY SYSTEM:
A. OROPHARYNX: NGL
B. SALIVARY GLAND: NGL
c. ESOPHAGUS: NGL
D. STOMACH: NGL
E. SMALL INTESTINE: NGL
F. LARGE INTESTINE: NGL
G. PANCREAS: 27 X 1 x 0. 3 em - NGL
H. LIVER: 175.07 g (total weight)
I. BILIARY SYSTEM: NGL
UROGENITAL SYSTEM
A. KIDNEYS: NGL
- 2 -
GROSS NECROPSY NOTES
- NGL
C. URETHRA: NGL
D. GENITAL ORGANS:
1. GONADS: NGL
2. ACCESSORY SEX ORGANS: NGL
XI, LYMPHATIC SYSTE21:
A. PERIPHERAL LYMPH NODES:
1, CERVICAL: NGL
2, POPLITEAL: NGL
B. THORACIC LYMPH NODES:
1. TRACHEOBRONCHIAL: 0.26 g (total weight) - NGL
2 . STERNAL: NGL
3. MEDIASTINAL: NGL
C . VISCERAL LYMPH NODES :
1. HEPATIC: NGL
2. ANTERIOR MESENTERIC: NGL
D. OTHER LYMPH NODES: NGL
E. TONSILS:
There was minimal bilateral reddening of the tonsils.
F. THYMUS: NGL
G. SPLEEN: NGL
XII. HEMATOPOIETIC SYSTEM:
A. FEMORAL MARROW, PROXIMAL, AND MIDSHAFT: NGL
B. RIB MARROW: NGL
C . VERTEBRAE MARROW: NGL
XIII. SKELETAL SYSTEM:
A. APPENDICULAR SKELETON: NGL
B. AXIAL SKELETON: NGL
XIV. MUSCULAR SYSTEM: NGL
XV. ENDOCRINE SYSTEM:
A. ADRENALS: 0.97 g (total weight) - NGL
B. THYROIDS: 0.55 g (total weight) - NGL
C. PARATHYROIDS: NGL
D. PITUITARY: NGL
XVI. NERVOUS SYSTEM:
A. BRAIN: NGL
- 3 -
GROSS NECROPSY NOTES
B. SPINAL CORD: NGL
C. EYES: NGL
D. EARS: NGL
XVII. PHOTOGRAPHY: None
XVIII. CYTOLOGY: None
XIX. OTHER STUDIES: Lung lobes distributed per protocol
XX. ANATOMIC DIAGNOSES:
1. Lungs: Adhesions, fibrous (RD to RI and LAC to LD).
2. Lungs: Discoloration, grey.
3. Tonsils: Inflammation, minimal.
4. Scheduled sacrifice.
XXI. COMMENTS:
The appearance of the lungs suggested a chronic,
resolving, pneumonia.
XXII.
- 4 -
GROSS NECROPSY NOTES
INHALJfTtoR TCOOConfclY RESEARCH INSTITUTE
GROSS NECROPSY R!,I(OS;�" Date II- z I� I T•m• ---- we.ght .1:.;L_,g
I 15'1�c__ HUC 19112
� Sacnf"ed 0 Eu�
d
II Authonzed By (3. Ct _Jj{_�. S= �iCM Of UOI .Ap'f/"J.'/2- 0 D•ed-FoundBy ____ :_ _____ _
o �ra r"•- 11111 f '( Yl•0l6 Clinical DiagnosisJ.JOrr'r"aJl a."'' 1\..\- rece\'isd 4011
C:Oo •. 13/l·'j H, 1 \'lr,'\1 .l-V.
Clinician -------------Principal Investigator ----------
0 NOT SAMPLED FOR HISTOPATHOLOGY
�����==============�==��==�== ! ,;;;,.;'/1-�_,0/�/���7"-'---"F�:«;:;T,:;;;c•'-'�=- of Necropsy WEIGHTS AND MEASUREMENTS
,� .... '6'23 � ib7/
(7m .. ...,,�r_ c..,,_,,,_ ··�··"'-' r:e """"'"" -�J;,. t<./1
Stains (circle) H&E
Number of Slides
Oat• to�.,---"''""---
CAVIflfS
'"""'
MEDIASnNAllN
CEIMCAl.lN
ANT MtSSE"TtiiiCLN
POI'Uru.t.LN
OTHEALNIII� SPLEEN
A-A Specials
URI�YBtADOER
""'"""
SEMIHAI.Vl:SIClE
""''�
Ht. Wt. _gm LV;�m RT.V _gm
RAvticm LAV�. ���'&cm AVMcm
LVM Hem RvMd3:m Lung .sf.Y! gm
TBLNd' ,..;}{:, gm Adrenal6 • 9 J gm Thyroid l),�gm
Kidneys __ gm Liver /7.S.o Zgm Spleen ___ gm
Brain ___ gm Panc.dlx_l__ X .. 3 em
Other ----------------
PROVISIONAL ANATOMIC OIA�OSIS
1. �: � {!(D;t,--<xr'"' a.,L L-11-C- J9-- L,D),
-< .�--:��._:� ��P"""'..-......__ ,
3, 7;.,_�- J���/ �.;:/ tt � � /"'-rz�
(u��,;.._)
Pathologist 2't.cs.&)..f'4d/ CENTRAL RECORDS
Date 1/�IP/
MEDICAL HISTORY OF DOG: 1548 C
BORN o
Giardia canis Isospora rivolta Bacterial infection, site unknown Parvovirus titer 1 :40
Assigned to MRIC
Tail tip broken
Calculus, dental, mild BAL: RD
TRC:adm file: C:\HISTORY\ 1548C.MED
DATE
NOTED
89182 89230 89230 89300 90056
CURRENT DATE
STATUS RESOLVED
Unassigned Colony
89349
89349 89311
91022 IFY91-0261 91191
91191 91219
TREATMENTS AND/OR DIETS OF DOG: 1548 C
89234 Metronidazole (Flagyl), 1/2 Tablet, Oral, Sid for 5 days, then re-test fecal
89317 Re-test fecal 89349 Re-test fecal
/pis WP FILE: c:\TREATMT\1548c.tre
iJOG: �548C 1 DATE:9i/i82 LOCA?:ON: ,rL-;?'3
</A.,GUAR::> DA2PL�CPV ·G:VK� BY&�:¥� TEC��IC:AN ONLY!l vACC:�-:1: SER�AL �lJMBER: ...ui!.,0'-'-/-'-7 0-fl�"'- O"'B� O'"'>=•"' L""E""l
>/ACCN"E EXP:iRA?:iON DATE: ,l,'tJooq<l
AJ"iOU�"? : _ ML ROU?E :SQ S.LD YEARLY
1 ON BOTI'LEl
7(7(11 DATE VACC.i.:NE G:i:VEN: ia:V ;tj..� .. (JULIAN l
1 '\ DATE 91 '3, 5
CF FlED
N�"OO"�NN�"OO •• NOO"O
.... . . ·••"
•o��O��N�O��o-�mONOO
. ... . . . . ··- ··-
.. INHAlATION TOXICOlOGY RESEARCH INSTITUTE
BRONCHOSCOPY REPORT
8 9182 "
rfCH Of RADI CTH£R THA� IIIII Fhl-026
� Anesthesia: fYLl,t) lnnovar-Vet & Atropine Diabutal
Surital
Dosage Route
/ / /
/ / / 4D71 Halothane/D.., 5'1�-"Jt _._hAl
Procedures
Rigid Bronchoscope Flexible Bronchoscope
Photographs
Visual Findings
Diagnosis
Clinician
Othoc 1\.c.e nro�•�<-
Date
WHITE- CENTRAL RECORDS CANARY- CLINICAL PINK- PATHOLOGIST
z._..,.,, �&. \ ...,.,
EXPOSURE DATA SHEET- LARGE ANIMAL EXPOSURES
ANIMAL TATTOO #: ____ J_�_- _1{�L _____ Verified by (Initials):�
EXPOSURE DATE: __ _.fu.I_,_30:.J/--'"1-'-/ __ JULIAN DATE : -----''j'-'-1"'?---''1_:)...:=_ ___ _
STUDY DIRECTOR:�J�.F�-�e�cdhrrn�e�r�-------------------------------
AEROSOL SCIENTIST: __ M�.D�.JHllo�o�v�e�r�------------------------------
EXPOSURE SYSTEM OPERATOR: ______ ������ ��� �-------------------PROTOCOL NO. FY91-026 PROTOCOL TITLE: Mechanisms of
Radiation-Induced Cancer
COST CODE: __ �4�07Ll�----- PROJECT TITLE: Mechanisms of Radiation-
Induced Cancer
TOXICANT: _______ 2_3�9P�u�1 _6_9�Yb�---------------------------------
METHOD OF EXPOSURE: [INHALATION_X_ INSTILLATION __ INTRAVENOUS_
OTHER·-------------------------------------
EXPERIMENT#: 5�]�-0D!
SPECIES: Beagle Dog
ANIMAL #: 00 (
WEIGHT (kg) '---47-'---'-- '1-'---- SEX: �
COMMENTS•---------------------------------------------------
xc: Medical Records [Green copy] Mr. E.B. Barr Study Director
1548C
H Of RAO; C I R TIUN I 11M
F v J 1 -fill: 4 1
Procedures
Rigid Bronchoscope
Flexible Bronchoscope
Photographs
Visual Findings
RIGHT
Diagnosis
Clinician
INHALATION TOXICOLOGY RESEARCH INSTITUTE
BRONCHOSCOPY REPORT
Other
So
Bo
LEFT
WHITE- CENTRAL RECORDS CANARY CLINICAL PINK PATHOLOGIST
Route
PHYSICAL EXAMINATION (AN)
( ,�\\ (Short Form) W.0 •. _"-/ "-1 #=..)._.'f'-':).._ __
Tattoo Number I SC/'6 C- (N-Normal) (A-Abnormal)
A. Date 7-tb-'i I B. Weight 7 (p W !1111 c. Height (Shoulder) __ ._
D. Body Temp. (rectal ).lQQ._.j_ E. Pulse Rate (femoral) /O'i ..
f. Resp1�at1on (rate/min.)� G. General Condition:
1. Comatose 2. Poor 3. Fair
4� c::2::::_ Excellent �
COMMENTS :
Technician
1. Attitude 2. Conformation 3. Hydration _ 4. Nutritional status _ 5. Superficial lymph nodes _
6. Membrane color 7. "Skin and ears 8. Eyes 9. Musculoskeletal system
10. Respiratory system 11. Cardiovascular system 12. Alimentary system 13. Urinary system 14. Genital system IS. Nervous system 16. Endocrine system 17. Teeth and gums
Clinician
./
PHYSICAl EXAMINATION (AN) (Short Form) W.O. (\ '1 J 50 ;?.
Tattoo Number IS'--\ 8C (N-Normal) (A-Abnormal) A Date')o ;;;> 51 "\/8/'lo 1. Attitude •
2. Conformation B. Weight] 'b 00 gm 3. Hydration
c Height (Shoulder) __
._
4. Nutritional status _
•
5. Superficial lymph nodes _ D. Body Temp. (rectal )J£.Q.._l 6. Membrane color
E. Pulse Rate (femoral) 1.:2 0. · 7. ··skin and ears F. Respiration (rate/min. l..3Q\ �: ����uloskeletal system G. General Condition:
��: �:��J�!�����:�·�;�tem 1. Comatose 12. Alimentary system 2. Poor 13. Urinary system 3. Fair 14. Genital system
COMMENTS:
15. Nervous system t 16. Endocrine system 17. Teeth and gums
NEW MEXICO DEPARTMENT OF AGRICULTURE
VETERINARY DIAGNOSTIC SERVICES 700 Camino de Salud NE Albuquerque. New Me�ico 87106 Phone (505) 841·2576
Page: 2
9002061 1541T 9002062 1542B
9002063 15428
9002064 1542T
9002065 15438 9002066 1544A 9002067 1544B 9002068 1544S 9002069 1544T
9002070 1544U 9002071 1545T 9002072 1546A 9002073 1546B 9002074 1546C 9002075 15460 9002076 1546E 9002077 1546F 9002078 1546G 9002079 15468 9002080 1546T 9002081 1547A 9002082 15478 9002083 1547T 9002084 1547U 9002085 1548A 9002086 1548B 9002087 1548C
9002088 15488 9002089 1548T
9002090 1548V 9002091 1550B 9002092 1550T 9002093 1551C 9002094 15518 9002095 1551T 9002096 1552A 9002097 1552B 9002098 15528 9002099 1552T 9002100 1552U 9002101 1553A 9002102 1553B 9002103 1553S 9002104 1553T
I :640
I: 160 1:160
1:160 1:40 I :80 I :80 I :20 I :20
I :40 I :40 I :1280 I :80 1:40 I :640 I :1280 I :640
I :160 I :80
1:160 1:40 1:320 I :40
I :80 1:40 1:40 I :40 I :640 I :80
I :640 I :640
I :320 I :1280
I :640 1:320 I :40 I :1280 I :640 I :160 I :80 1:160
1:80 I :80 1:160
Case: Species: Owner: Animal Name:
90-02025 Canine
Lovelace P090005110006
16 .Lj'l-c /1-lcJ
INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT
HISTORY (Reason for submission)
r;'{fi \ DATE SUBMITTED 1;-;.j;.s-/8 X REQUESTED BY
0 URINALYSIS COLLECTION METHOD
Compression ___________ _
Catheterization __________ _
Cage _ ____________ _
Other _ ____________ _
CHEMISTRY (chemstrip·Bl Sugar ____________ _::m"'g/-"'dl Albuminl ___________ _:::m!!!.g/:::dl
OMICROSCOPIC COMMENTS· DIRECT
Hemoglobin ERY/ug CYTOCENTRIFUGE Acetone ____________ _
Bilirubin _ ___________ _
Urobilinogen __________ _:_m"g'-"'/ d l
Occult blood __________ ER"-Y'-'-/""ug
Nitrite Sp Gr -------------pH ________________________ _
Color _____________ _
Turbidity ____________ _
MICROSCOPIC WBC __ _ _ _ _ _ _ _ ___ __
ABC _ _ __ _ _ _ _ _ _ _ _ _
Casts Hyaline'------------
Granular·-------------
WBC or ABC ___________ _
Other ____________ _
Bacteria ____________ _
Renal Cells-----------
Crystals-------------
CENTRAL RECORDS
TECH/PATH Date
::¢i'���;�EOUESTED paraSites 0 Trypsin OOther Procedure Used ______________ _
Results
TECH/PATH-/f-1.,/;_-f/-�--- Date//"'
) ,. l
"· . . .. ·-·- _____ ___.__:_:-c.�. .. -�--·-
OBSERVATION
IY: -:r 11.J. s eoo MIIW. Ill: LdieR 1.51../2 Date: IJ,/; y/gq f9.3</:r
Tl1M _LU:fu_ cj IKV� wtM
/5'-/�A iS'/� 6
.15'-18c. /5'-/g s,
· IS'-I'i!T 154'E v
-/-w-nx OVJ !t)ujs-7 (F9321R) M ..),�?? o_:s. �OSj70?..ct MNo-i+a c..�- Wij w-?u /JoY
ka..ttl � �- We wtd /zaw. � --Jeccd J/.e -1-e.:vte cl lo _foe.e 11 � ..ho ("� /v
[/ !: !J (} ' jJ � J/.L ihvt je ceJ
JW3 /s,J v/iJJ��J/31?
C!;1s<�o . ·
INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT
HISTORY (Reason for submission)
REQUESTED BY DATE SUBMITTED // p:2)g' 1
0 URINALYSIS COLLECTION METHOD
Compression ___________ _
Catheterization ______ ____ _
Cage _____________ _
Other _____________ _
CHEMISTRY (chemstrip-8)
Sugar ____________ _::m:!!g/�dl
Albuminl ___________ __:::m:t_g/�d l
OMICROSCOPIC COMMENTS DIRECT
Hemoglobin ERY/ug CYTOCENTRIFUGE
Acetone ____________ _
Bilirubin ___ _________ _
Urobilinogen __________ _:m::og�/dl
Occult blood _________ _:.Ec:.RY"-/"-'- ug
Nitrite Sp Gr -------------pH ________________________ _
Color _____________ _
Turbidity ____________ _
TECH/PATH
MICROSCOPIC ����;�EOUESTEO �Parasites
Date
OTrypsin OOther WBC _ _ _ _ __ _ _ _ _ _ _ _ Procedure Used ______________ _
ABC _ __ _ _ _ _ ___ __ __
Casts
Hyaline ____________ _
Granular ____________ _
WBC or ABC ___________ _
Other-------------
Bacteria ____________ _
RenaiCel!s -----------Crystals -------------
CENTRAL RECORDS
Results
TECH/PATH------'a_.w.�"--- Date 1//:t:J� I�
' ------ --- --'----
OBSERVATION
IY: T&i/ s pua MIIIAL Ill: /$ L/ 8r Date: 11 In h1 Rr.317 }
l fl,s J-:ecc,/) lie �M �tux- pC/)_1/VJ.H' -/r"'- /J_ai!VYI�
/JWj ./ICI/U .f:lc�.-u::Liet CaJ�'J. :J/"' Jerc:x__( >{)arnj2h..
wa.1 /cu:t_,'" .--t_� .Ju ?UM _ljYI 'Me -!?a:1,aut-cJ /JLjc/'..£ lk /Uj)l7'.i:- {'CvJ'?'U ftu,t --/Lc. t-UOLJ {]frd
k lh h/17/YLd , /Ja d lu �-" _L(_w� -ftlcci'ta
f].J,A-£ � uJ&u rfi/1-<J /!aLL £ir ;/) oL< � f'c1-� ?!/( wiD 11crl frt?( i .,A;c. JYJ a t
'f}LUJ 1:Jo-r/� -t . He t vu ( -:1'7 av-e _/'uo -/<' <C<-(
/U #.:2 (; ct A-·Y1 d tA/a &J.
/ . !Jr/ CJ. j) It t�cu /U- - kd /e rc:u /0-uJ;U c 1 s Y g C"/7 g c;Ja:it
/�� ��93�
HOSPITAL ADMISSION and DISCHARGE
Kennel HIO
l. 2.
3.
4.
5.
6.
7.
8.
9. 10.
Temp__l6_l!__pulseJ1l.lResp__lk_)leight 5: CJ
II.
!2.
13.
!4.
15.
1\n r\ ' 16.
occ )('CJ , ercc:s.siO(') 17.
Attitude Confonnotion Hydration tlutritional status Super. lymph nodes Hembrane co 1 or Skin and ears Eyes
tlonn. Abnorm.
Musculoskeletal sys. Respiratory sys.
-
Cardiovascular sys. Alimentary sys. Urinary sys. Genital sys. Nervous sys.
· Endocrine sys. Teeth and gums
Julian Date
c�>,3::G l'J'I.!x>i
19 't{.J
l�q'.l[':':
1)1 1(1;(,c
�•\ S � Qli?r, 1'
ih9Wh <tio9
zc,1,o
i-i2,(/
CLINICAL CHARo
General Comments:
\)L\SC
Appe tite
-�
-\
c=
Tn
7., ?
F'
r·, 7
r-
Bowels Urine T p R COMMENTS
{\
i \
lv
A �·
(l ,, �\
u "?.
Ito\�
hnillJ I iOD btJi) lP
(•,
C?c/Gu.� -suDM•<+-> :\ i'\<-< �"' l,, \c.,\ !d� "''""-::_m (, � (' """"- \
�) k. ,, -\-en,,, 1 e ,,, () () (_.--., �� '"' <:·lnr\ )-<,f",\\ -<_ . "'' . .
r\,,e> n -� M\ ,j I�.H \c, , . . f h. J '),) ,, ,, ' i!U( tit (,
L-u.;k.� "''" ,\ r ,A,,, ' ,A, · � "''� (' \ \ A A. I..- )
A)_ i / j· -
7 7 "'.:::=<--.:.... (- 1<'0 'v\ \_·"t" f'tY•,.-l <r>-\-/cX:P._Ck-rf
') ":Jt ' ., <: c\ ; � i"A" th<). '
Jmr: 1("{f(':f"\(Ghf r"- i..J.A-J }1wir,,h;.1 �· I�- �.:-\• .;J,d
tO<;J iJ'�v-._ � �A. c.,,k nv0rntoh-t 11,-
(S Loof:c � I' :; . .t/, ..-/,'/h.,Y>. / ,;, te. /;;;;I:\ !We< .;,,.,,,� J /'VL
./. � ! 7/ ,/ /l.·J f: u.
lrm -,,..,,.,"""' -:>.rl-< U Ia� -I- '.., ?.ld< '� -�<SC/r.''-"-<-""' 1"2>-v 1::" c:...- 7T9r
"'"� .�'] !'r· ' ()(I , , _ _ .(),, ;a .. ,
l ?"
ABBREVIATIONS: Appetite: F=fau. G-good, P-poor, 0-none. Bowels: N-normal, D-diarrhea, DB-diarrhea with blood, 0-no feces. Urine: N-normal, A-abnormal, 0-none.
ORDER SHEET
General C omments:
\ �l� c c
IJ u 1 i a n1 l<ork Order
Date 1 ORDER Clinician Issued Conoleted
:C,":£(' ChL/ (L'-"''\ \", \1.,\ C."'�(( v
I
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I i ' i
I i I I I
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\)l � :
u ·�
i lr.oP>�t)C',... 'Q,.... ..., ..., ...., «>
I IN •0 -< • • • • •N I I _,.., .,.., ...... ON
' ' " ' '
' ' ' ' ' ' ' ' I I '""'"""'�"'0"""'-<"' I I ... ,..,.,. .... • • • • •M I I O-< lnMC> ... ON ' ' " ' '
' ' ' ' ' ' I l.l..:l.l .l..:l.l.l I I PIJtl.l.l..:l .. u:u:O P CI I I '-'-'-'-'-PO'-..'-'-.'-. I I CICICI::>=>'-'.CICICICI I I:CI::I:..,...,CICI:C:ICil!:il!:
' '
u' ' . ' ' . ' ' . ' ' "' '
' ' ' ' ' ' ' ' ' '
' ' ' '
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j
INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT
HISTORY (Reason for submission)
REQUESTED BY DATE SUBMITTED 1/,k,/rq (J6?) 0 URINALYSIS
COLLECTION METHOD Compression ___________ _
Catheterization _ _________ _
Cage _____________ _
Other _____________ _
CHEMISTRY (chemstrip·B)
Sugar ____________ c:m::! g/'-"dl
Albumin, ___________ __:::mq /,_ de:l
0MICROSCOPIC COMMENTS DIRECT
Hemoglobin EAY/ug CYTOCENTAIFUGE Aceto ne ____________ _
Bilirubin ____________ _
Urobilinogcn __________ _::m::!g/'-" dl
Occult blood _________ ___.:::ER.:._Y� /u::.'!g Nilnle ------------
Sp G< -------------
pH ____________ _
Colore _____________ _
Turbidity ____________ _
MICROSCOPIC WBC. _ _ _ _ _ _ _ _ _ _ _ _ _
ABC _ _ _ _ _ _ _ _ _ _ _ _ _
Casts
Hyaline, _______ _
Granular ____________ _
WBC o< ABC. _________ __ _
Othe<·--------------
Bacteria ____________ _
Renal Cells ___________ _
Crystals ____________ _
CFNTRAL RECORDS
TECH/PATH Date
jl(FECAL TEST REQUESTED J;{Pacasctes 0 Trypsin OOther
ProcedureUsed• --------------
Results
TECH/PATH ____ ,L(\;.,Ow__ oate «h/S?'j
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INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT
HISTORY {Reason for submission)
REQUESTED BY DATE SUBMITTED 9,/i,/rt:j r; 'f'f)
OURINALYSIS COLLECTION METHOD
Compression ___________ _
Catheterization __________ _
Cage _____________ _
Other _____________ _
CHEMISTRY (chemstrip·8)
Sugar ____________ .::.m::!!g/:e:dl
Albumin ___________ __:::mg�/dl
OMICROSCOPIC COMMENTS· DIRECT
Hemoglobin ERY/ug CYTOCENTRIFUGE
Acetone ____________ _
Bilirubin ____________ _
Urobilinogen __________ _::m�g:::.:i dl
Occult blood _ ________
___:::ER�Y:c_/:::!ug
Nitrite ------------
Sp. Gr. -------------
pH _______________________ _
Color _____________ _
T urbidity ____________ _
MICROSCOPIC
WBC _ _ _ _ _ _ _ _ _ _ _ _ _
RBC _ _ _ _ _ _ _ _ _ _ _ _ _
Casts
Hyaline ____________ _
Granular ____________ _
WBC or RBC. ___________ _
Otherr--------------
Bacteria ____________ _
Renal Cells -----------
Crystals -------------
:ENTRAL RECORDS
TECH/PATH Date
illfF ECAL ../'rEST REQUESTED �Parasites
Procedure Used ______________ _
0 Trypsin OOther
Results
TECH/PATH ___ _,cv�--- D a •e 9/r i-?7
OBSERVA Tl ON
BY: 68�a� ANIMAL IIi: C1 Date: 89J33 SjJ I ]89
For -he.Dltmen+ o+ Gi.urcltix Co.ni� lS'-1'8"\/
pV.Qse pla__u_ +hese pu.ppw:> on '/z_ -fa.ble+
0 4' me.+ ron\ cla<o /e. ( F-lo. j'j I ) p, 0. s I 0 X s d
+he.n re. -lest t'e Co.. I So.. m ple. .
-OBSERVATION
:;MAL ,; i�4!0 P��r Date: 8'"1 �35 '8 12.3/8"\
154'8 f\ \5�'6 2 ISL\-8 C \st48S
/SLf8 T \5'--f8�
\l c,_v\:)" o__rc\ 1::l - M ( D, -s-k.M p �
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()<'. -gq�35
INHALA .. -.. tOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT
HISTORY (Reason for submission)
/ \ ( :?-Jd)
REQUESTED BY DATE SUBMITTED $,/1'1/dCj
OURINALYSIS COLLECTION METHOD
Compression ___________ _
Catheterization __________ _
Cage _____________ _
Other _____________ _
CHEMISTRY (chemstrip·BI Sugat ____________ .::m:l!g/.:!:dl Albumint ___________ __:.::m�g/d l
0MICROSCOPIC COMMENTS DIRECT
/iea-l::ed SID x Sd
metronidazole.. Gt arcb."a. funIs
Hemoglobin ERY/ug CYTOCENTRIFUGE·
Acetone __ __________ _
Bilirubin ____________ _
Urobilinogen __________ _::m:::!g�/dl
Occult blood ________ _ _:_ERc_Y:.:_ i::.u g
Nitnte -------------Sp Gr ---------------pH __ __ _ _ _ _ _ _ _ _ ___
Color _____________ _
Turbidity ____________ _
MICROSCOPIC WBC __ _ _ _ __ _ _ _ _ _ _
ABC _ __________ ___
Casts Hyaline _________ ___ _
Granular _ _ __________ _
WBC or ABC. ___________ _
Other ____________ ___
Bacteria ____________ _
Renal Cells ___________ _ Crystals -------------
TECH/PATH Date
il!FECAL .., 1-EST REQUESTED JffParasites 0 Trypsin DOther
Procedure Used _ _____________ _
Results
TECH/ PATH---'aa_...._ ___ Oatet-i&.l,<hca.JI'./-/-'l.U';t__
�
::AGE
PRO'IOCDL FY91-026 MECH,NISMS 0:1F R�INDUCED CANCER
ASSIGNED AS •) • ;11 201· \ Ju l y 25' t·:.·:11)
TA.TTOI�I 1/MI::THOT '"' ; V M_C3TCD "·/M_TITLE
1':"·41 T :::·::' 14':"· F 4(i7l RADIA.TION INDUCED CANCER
1'54.:.C: :::·."I/ 1':"·4 M 4U71 RADIATION INUUCEO CANCER
1'54.:3 :::·:'/1':·4 F 4(1{ 1 F.AO!AT!ON INDUCED ':ANCER
1':·44_.-l. ::::·� .. ! :.-:, M 4(•71 f'."ADI�TION trJOtXED (A.N(:;::F\
1'544E: .::·;I/ 1'5 :: M 4071 RADIATION INDUCED CA;J·:;:s·
��443 :;:·::/ 1 ':• :, F .�(·7! F:40i.:OTI':'N !NDUCEJ ·� ;.r�·: F�: 1'544T :::·:'1/15":0 F 4(171 RAOIATII)N INDUCED •:AN(EF."
1544U :3'''/1�:, F 41)71 RAD!ATION INDUCED ( ANCER
1545T :::·;1/1..:.:3 F 4071 RADIATION INDUCED CANCt::R
1546A :::·:1/1-::·5 M 4071 RADIATION INDUCED CANCER
1'546C 8'?/ 165 M 4(.171 RADIATION INDUCED CANCE.R
1'54..;.3 :::·;1/1<.:·5 F 41)71 RADIATION INDUCED CANCER
!'546T ::::·:'/ltE� F 407 1 RADIATION INDUCED CANCER
1'54 7A :::·?/16:3 M 4071 RADIATION !NDUCED CANCER
1'547S :3'?/168 F 4071 RADIATION INDUCED CANCER
1'547T :39/168 F 4071 RADIATION INDUCED CANCER
1547U :39/168 F 4071 RADIATION INDUCED CANCER
1'548A ::::o;Jf t:::.:. M 4071 RADIATION INDUCED CANCER
15488 :39/t:S.:: M 41)71 RADIATION INDUCED CANLER
t'54:::c ::;9;1:::2 M 41)71 RADIATION INDUCED CANC.ER
1548S 89/t:::tz F 4071 RADIATION INDUCED CANCER
1'543T ::t·:;lf1SZ F 4071 RADIATION INDUCED CANCER
1'543V 89/18Z: F 4071 RADIATION INDUCED CANCER
15�0B 8'?1!';>1 M 4071 RADIATIIJN INDUCED CANCER
1551C :39/1'?6 M 4071 RADIATION INDUCED CANCER 1551S 8"?/ 196 F 4071 RADIATION INDUCED CANCER
I5'5IT 89/1'?6 F 4071 RADIATION INDUCED CANCER
1!552A 89/ZOO M 4071 RADIATION INDUCED CANCER
155Z:Et 89/Z:OO M 4071 RADIATION INDUCED CANCER
I'5'-52S :3:9/201) F 4071 RADIATION INDUCED CANCER
I552T 8'?/200 F 4071 RADIATION INDUCED CANCER
1552U ,39/200 F 4071 RADIATION INDUCED CANCER
155:3A 89/206 M 4071 RADIATION INDUCED CANCER
1'-5!5:3S 89/ZOO F 4071 RADIATION INDUCED CANCER
I556A 89/342 M 4071 RADIATION INDUCED CANCER
t556S 89 /342 F 4071 RADIATION INDUCED CANCER
15!57S 89/3!53 F 4071 RADIATION INDUCED CANCER
PAGE l
PROTO<DL: FY91-026 MECHAN I Sl"'S OF RADIATII)N !NDUCED
ASSIGNED AS OF qt.:(ll:. (J '.l! y .::.5.
TATTOO VME.THOTE SE:: VM_(STCD
1'5.:-1.:1, ::::3/ �:4(! M 41)71
1':·.:-H.: :::·:·; �:41) M ·•071
1 ':.:.4C :-:-: ;;-.<) M -V•71 1'5.:- 40 :=:;:::/ ::4(1 M 4(171
1 '5.:.4:; :::::::; ::4•) F 4(•71 l':.:.':·A ·::::::I �'4:::: M -H)ll t5.:5s :;:·:: / �:4::: F 407 1
t5.:5T ::::::::; �.4:� F 4011
t5.:5u :3:3/ �:4:3 F 4(1'i 1
1 !526A ·:;:·;1/t)l)l,:. M 4(171
t5z,.=.s :::·;1/l)(l.,:. F -l071
1526T :;:•,1/(H)Ii, F 4-071
1'5.::-.:-u :39/•)('1;. F 4071
15::'?A :=:·=1;1)2:� M 4071
1'52'i)T :;;·::.;1)23 F 4071
1530A :::;·;.;o::::r.:. M 407 1
15:305 :3'?102:6 F 4071
153tH :39/0:Z:o F 4071
15'31A :::;<:;�;o:::;o M 4-071
15.31B :39/0:30 M 4071
15328 ·::·_;.;()41) M 4071
1532C 891040 M 4071 1�33A 89/078 M 4071
15338 :3'?/078 M 4071
15'33C 89/078 M 4071
15335 $9/078 F 4071
1533T 89/078 F 4071
1�34A 89/099 M 4071
15348 89/089 M 4071
1'5:34C 89/089 M 4071
U53!5A 891114 M 4071
153!58 :39/114 M · 4071
1�3!55 s·n114 F 4071
1!53!5T $9/114 F 4071
1536A 99/114 M 4071
1!5365 99/114 F 4071
1536T 39/114 F 4071
15:36U 99/114 F 4071
15378 89/12:'3 M 4071
1537T 39/123 F 4071
15388 89/134 M 4071
1!5:39A 39/140 M 4071
1'539G 8'?/140 M 4071
15.3'?D 89/140 M 4071
15:39S 89/140 F 4071
1'5-40A :39/141 M 4071
15406 :39/141 M 4071
154t)S 8'?/141 F 4071
1 '540T 89/141 F 4071
CANC ER
t•:,-:11)
·,,;r..,_ T ITt E
I:::A.OIATi·)N
hAD!AT!ON
�.A C.! "\liON 1-:ADI,), T!I)N
n:AD I� 1 11:1N
RA.QI.:.T[I)N
·� :r.Q! :r.i'II..)N
r;:ADIAi[ON
RADIATION
RADIATION
RADIATII)N
,::P.Ol A.TII)N F':.AOtATI:JN
F:AOIATION
RADIATION
RADIATION
RADIATION
RfJ.DIATION
RADIAT!ON
RAOIA TII)N
RADIATION
RADIATION
RADIATION
RADIATION
RADIA TION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
RADIATION
INDUCSi) tt-.IDLJCED
Il'l['UC:::;:.
I�JI)IJO:ED
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1i·2�"�r:.::= If'-J�•IJC!:::G
INDU(E.)
INCL!CED INDuCED
INDUCE[•
INOU(t::J
INDU•:.E�
INDLXED
INDUCED
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TNOUCED
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tNDIJ(ED
INOI..J(ET)
INDUCED
INDlJCEo
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.. '· . ..
· '' "·
.:.cJ•:'=-,: - \" � =: -:·
.. -,_;::.;::
-�c:;
:;.,'L ' · --
,:r.: j·� := .. ;;. · -
,,_ �- .;
·: ..:. , J·� =: .-. - •. =--
.:(). · ; · .::::---
•:;..rn:E;:· :AN•:c::,�
.: ��'·'� ::;:;; <:.1\i.'.:'=R ·� ..:.�1·: �F •� � "I•: 7:F' .:: �)\j•' c:_;:;
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:: .... ct::_c: • .:.i'l'��� : "r.l( E!:', .;: �l'lCEF:
LANCER (>l"KE,:· t:.AN(E�· CAI'J(�R
•:ANCEF.
C ANCER
(AN( EFi' ::4NC�R
C�N(�:=;·
( AN(S�
r_ ANCER CANCEF:
C Ai..:C ER
(.:.<KER -: .;•,KEF:
t ANCER
r.AN(ER
CANCER C;li'J(ER
:-P.M.:EP I� fq'J<:J:=.r=..
TABLE 2 C ( C j)-
Mechnisms or Radiation Induced Cancers: I .
Assignment of Dogs for Studies Other Than Immunology
Malrlfattoo Blrthdate Maleffattoo Blrthdate
1491 B 87133 1538 B 89134
1494 D 87143 1539 A 89140
1495 c 87147 1539 D 89140
1506 D 88004 1546A 89165
15078 88032 1546 B 89165
1508 A 88043 1546 c 89165
1510A 88081 1546 D 89165
1513 B 88120 1546 E 89165
1513 c 88120 1546 F 89165
1514 B 88133 1546 G 89165
1518 c 88261 1547 A 89168
1518 D 88261 1548 A 89182
1518 E 88261 1548 B 89182
1518 F 88261 1548 c 89182
1521 A 88279 1550 B 89191
1521 B 88279 1551 c 89196
1522 B 88323 1552 A 89200
1523 A 88330 1552 B 89200
1523 B 88330 1553 A 89206
1524 A 88340 1553 B 89206
1524 B 88340 1556 A 89342
1524 c 88340 1557 A 89353
1525 B 88348 1558 B 89354
1532 c 89040 1558 c 89354
1533 c 89078 1560A 90055
1534 A 89089 1560 B 90055
1534 B 89089 1565 A 90163
1534 c 89089 1565 B 90163
1534 D 89089 1567 A 90270
1534 E 89089
TABLE I
Mechanism of Radiation Induced Cancers: Assignment of Dogs for Studies Other Than Immunology
[emal!l[attoo Blrthdatr: Femaleffattoo Birthdate
1498 u 87180 1525 s 88348
1501 T 87227 1529T 88023
1502 s 87228 1537 T 89123
1508 T 88043 !541 T 89145
1509 s 88062 1542 s 89154
1509 T 88062 1545 T 89163
1509 u 88062 1546 s 89165
1511 s 88088 1546 T 89165
1511 u 88088 1547 s 89168
1512 s 88111 1547 T 89168
1512 u 88111 1547 u 89168
1514 T 88133 1548 s 89182
1514 v 88133 1548 T 89182
1515 T 88141 1548 v 89182
1515 u 88141 1550 T 89191
1515 v 88141 1551 s 89196
1516T 88146 1551 T 89196
1516 u 88146 1552 s 89200
1517 u 88160 1552 T 89200
1521 s 88279 1552 u 89200
1521 T 88279 1553 s 89206
1521 u 88279 1553 T 89206
1522 s 88323 1553 u 89206
1522 v 88323 1556 s 89342
1522 w 88323 1557 s 89353
1523 s 88330 1560 s 90055
1523 T 88330 1560 T 90055
1523 u 88330 1565 s 90163
1523 v 88330 1567 s 90270
1524 s 88340
INTEROFFICE MEMORANDUM January 22, 1991
TO: Dr. F. F. Hahn
FROM: Dr. B. A Muggenburg �
SUBJECT: Mechanisms of Radiation Induced Cancer: Assignment of Dogs for Studies Other than Immunology
The dogs listed in the attached tables are available for this study for exposure
after January 1, 1991. We have assigned equal numbers of males (59) and females (59).
These dogs were born from May, 1987 to September, 1991. This allows for an exposure
window beginning now until October, 1991. Ten extra dogs were assigned to allow for
the exclusion of dogs that receive too much or too little plutonium aerosol.
BAM: pis WI Attachments
XC: Dr. C. H. Hobbs Dr. D. G. Thomassen Dr. B. B. Boecker Dr. N. F. Johnson Dr. K. J. Nikula Dr. D. G. Burt
Recommended