CLINICAL SUMMARY

EXPOSURE OATE: AGE AT EXPOSURE: ) DEATH DATE:

���S A;O������OSURE: 1f!f3

TATIOO= .:t-sioC BIRTHOAT� : ?qlo 9-SEX: M �() 4 I I" SIRE: 1 ,/ ,1,.1_ l10 '--OAM: 1 ""f, -,:"> sruo C J_ YY\ICt(_ fyt'f!c r;{)0

GROSS NECROPSY NOTES

I. ANIMAL IDENTIFICATION:

A. TATOO NUMBER: 1546C

B. SPECIES: Canine

C. DATE OF BIRTH: 69162

D. SEX: Male

E. TITLE OF EXPERIMENT: Mech. of Rad.-Induced Cancer

F, PATHOLOGY SERIES INDEX NUMBER: DA-040

G. EXPERIEMTN NUMBER: 5272

H. DATE OF EXPOSURE: 91242

II. HISTORY:

A. MODE OF DEATH (EUTH., SAC., DIED): Sacrificed

B. DATE AND TIME OF DEATH: 91325 (11/21/91) 7:45

C. DATE AND TIME OF NECROPSY: 91325 (11/21/91) 6:00 a.m.

D. AGE AT DEATH: 673 Days

E. DAYS AFTER EXPOSURE: 63 Days

F. CLINICAL SUMMARY:

Scheduled sacrifice.

II. PROSECTORS: C. Maruszak, K. Garcia

IV. PATHOLOGIST IN CHARGE: Dr. Kris J. Niku1a

V. EXTERNAL APPEARANCE:

A. TOTAL BODY WEIGHT AT NECROPSY: 7.3 kg

B. PHYSICAL CONDITION: Excellent

C. POSTMORTEM CONDITION: Excellent

D. MUCOUS MEMBRANES: NGL (No Gross Lesions)

E. BODY OPENINGS: NGL

F. EXTERNAL GENITALIA: NGL

G. SKIN: NGL

H. SUBCUTIS: NGL

I . MAMMARY GLANDS : NGL

VI. CAVITARY FINDINGS:

A. THORACIC: NGL

B. ABDOMINAL: NGL

VII. RESPIRATORY SYSTEM:

A. NASAL CAVITY: NGL

B. PARANASAL SINUSES: NGL

C. LARYNX: NGL

D. TRACHEA: NGL

E. LUNG: 54.81 g (total weight) -

There were fibrous adhesions between the RD and RI lobes

and between the LAC and LD lobes. The lungs had a slight grey

discoloration.

F. MEDIASTINUM: NGL

VIII. CARDIOVASCULAR SYSTEM:

IX.

X.

A. HEART:

Total Heart: -

Left Ventricle and Septum: -

Right Ventricle: -

Right AV Valve: 7.9 em

Left AV Valve: 6.5 em

Pulmonary Valve: 3.1 em

Aortic Valve: 3.7 em

Left Ventricular Myocardium: 1.1 em

Right Ventricular Myocardium: 0.3 em -

NGL

B. PERICARDIUM: NGL

C. MAJOR VESSELS: NGL

ALIMENTARY SYSTEM:

A. OROPHARYNX: NGL

B. SALIVARY GLAND: NGL

c. ESOPHAGUS: NGL

D. STOMACH: NGL

E. SMALL INTESTINE: NGL

F. LARGE INTESTINE: NGL

G. PANCREAS: 27 X 1 x 0. 3 em - NGL

H. LIVER: 175.07 g (total weight)

I. BILIARY SYSTEM: NGL

UROGENITAL SYSTEM

A. KIDNEYS: NGL

- 2 -

GROSS NECROPSY NOTES

- NGL

C. URETHRA: NGL

D. GENITAL ORGANS:

1. GONADS: NGL

2. ACCESSORY SEX ORGANS: NGL

XI, LYMPHATIC SYSTE21:

A. PERIPHERAL LYMPH NODES:

1, CERVICAL: NGL

2, POPLITEAL: NGL

B. THORACIC LYMPH NODES:

1. TRACHEOBRONCHIAL: 0.26 g (total weight) - NGL

2 . STERNAL: NGL

3. MEDIASTINAL: NGL

C . VISCERAL LYMPH NODES :

1. HEPATIC: NGL

2. ANTERIOR MESENTERIC: NGL

D. OTHER LYMPH NODES: NGL

E. TONSILS:

There was minimal bilateral reddening of the tonsils.

F. THYMUS: NGL

G. SPLEEN: NGL

XII. HEMATOPOIETIC SYSTEM:

A. FEMORAL MARROW, PROXIMAL, AND MIDSHAFT: NGL

B. RIB MARROW: NGL

C . VERTEBRAE MARROW: NGL

XIII. SKELETAL SYSTEM:

A. APPENDICULAR SKELETON: NGL

B. AXIAL SKELETON: NGL

XIV. MUSCULAR SYSTEM: NGL

XV. ENDOCRINE SYSTEM:

A. ADRENALS: 0.97 g (total weight) - NGL

B. THYROIDS: 0.55 g (total weight) - NGL

C. PARATHYROIDS: NGL

D. PITUITARY: NGL

XVI. NERVOUS SYSTEM:

A. BRAIN: NGL

- 3 -

GROSS NECROPSY NOTES

B. SPINAL CORD: NGL

C. EYES: NGL

D. EARS: NGL

XVII. PHOTOGRAPHY: None

XVIII. CYTOLOGY: None

XIX. OTHER STUDIES: Lung lobes distributed per protocol

XX. ANATOMIC DIAGNOSES:

1. Lungs: Adhesions, fibrous (RD to RI and LAC to LD).

2. Lungs: Discoloration, grey.

3. Tonsils: Inflammation, minimal.

4. Scheduled sacrifice.

XXI. COMMENTS:

The appearance of the lungs suggested a chronic,

resolving, pneumonia.

XXII.

- 4 -

GROSS NECROPSY NOTES

INHALJfTtoR TCOOConfclY RESEARCH INSTITUTE

GROSS NECROPSY R!,I(OS;�" Date II- z I� I T•m• ---- we.ght .1:.;L_,g

I 15'1�c__ HUC 19112

� Sacnf"ed 0 Eu�

d

II Authonzed By (3. Ct _Jj{_�. S= �iCM Of UOI .Ap'f/"J.'/2- 0 D•ed-FoundBy ____ :_ _____ _

o �ra r"•- 11111 f '( Yl•0l6 Clinical DiagnosisJ.JOrr'r"aJl a."'' 1\..\- rece\'isd 4011

C:Oo •. 13/l·'j H, 1 \'lr,'\1 .l-V.

Clinician -------------Principal Investigator ----------

0 NOT SAMPLED FOR HISTOPATHOLOGY

�����==============�==��==�== ! ,;;;,.;'/1-�_,0/�/���7"-'---"F�:«;:;T,:;;;c•'-'�=- of Necropsy WEIGHTS AND MEASUREMENTS

,� .... '6'23 � ib7/

(7m .. ...,,�r_ c..,,_,,,_ ··�··"'-' r:e """"'"" -�J;,. t<./1

Stains (circle) H&E

Number of Slides

Oat• to�.,---"''""---

CAVIflfS

'"""'

MEDIASnNAllN

CEIMCAl.lN

ANT MtSSE"TtiiiCLN

POI'Uru.t.LN

OTHEALNIII� SPLEEN

A-A Specials

URI�YBtADOER

""'"""

SEMIHAI.Vl:SIClE

""''�

Ht. Wt. _gm LV;�m RT.V _gm

RAvticm LAV�. ���'&cm AVMcm

LVM Hem RvMd3:m Lung .sf.Y! gm

TBLNd' ,..;}{:, gm Adrenal6 • 9 J gm Thyroid l),�gm

Kidneys __ gm Liver /7.S.o Zgm Spleen ___ gm

Brain ___ gm Panc.dlx_l__ X .. 3 em

Other ----------------

PROVISIONAL ANATOMIC OIA�OSIS

1. �: � {!(D;t,--<xr'"' a.,L L-11-C- J9-- L,D),

-< .�--:��._:� ��P"""'..-......__ ,

3, 7;.,_�- J���/ �.;:/ tt � � /"'-rz�

(u��,;.._)

Pathologist 2't.cs.&)..f'4d/ CENTRAL RECORDS

Date 1/�IP/

MEDICAL HISTORY OF DOG: 1548 C

BORN o

Giardia canis Isospora rivolta Bacterial infection, site unknown Parvovirus titer 1 :40

Assigned to MRIC

Tail tip broken

Calculus, dental, mild BAL: RD

TRC:adm file: C:\HISTORY\ 1548C.MED

DATE

NOTED

89182 89230 89230 89300 90056

CURRENT DATE

STATUS RESOLVED

Unassigned Colony

89349

89349 89311

91022 IFY91-0261 91191

91191 91219

TREATMENTS AND/OR DIETS OF DOG: 1548 C

89234 Metronidazole (Flagyl), 1/2 Tablet, Oral, Sid for 5 days, then re-test fecal

89317 Re-test fecal 89349 Re-test fecal

/pis WP FILE: c:\TREATMT\1548c.tre

iJOG: �548C 1 DATE:9i/i82 LOCA?:ON: ,rL-;?'3

</A.,GUAR::> DA2PL�CPV ·G:VK� BY&�:¥� TEC��IC:AN ONLY!l vACC:�-:1: SER�AL �lJMBER: ...ui!.,0'-'-/-'-7 0-fl�"'- O"'B� O'"'>=•"' L""E""l­

>/ACCN"E EXP:iRA?:iON DATE: ,l,'tJooq<l

AJ"iOU�"? : _ ML ROU?E :SQ S.LD YEARLY

1 ON BOTI'LEl

7(7(11 DATE VACC.i.:NE G:i:VEN: ia:V ;tj..� .. (JULIAN l

1 '\ DATE 91 '3, 5

CF FlED

N�"OO"�NN�"OO •• NOO"O

.... . . ·••"

•o��O��N�O��o-�mONOO

. ... . . . . ··- ··-

.. INHAlATION TOXICOlOGY RESEARCH INSTITUTE

BRONCHOSCOPY REPORT

8 9182 "

rfCH Of RADI CTH£R THA� IIIII Fhl-026

� Anesthesia: fYLl,t) lnnovar-Vet & Atropine Diabutal

Surital

Dosage Route

/ / /

/ / / 4D71 Halothane/D.., 5'1�-"Jt _._hAl

Procedures

Rigid Bronchoscope Flexible Bronchoscope

Photographs

Visual Findings

Diagnosis

Clinician

Othoc 1\.c.e nro�•�<-

Date

WHITE- CENTRAL RECORDS CANARY- CLINICAL PINK- PATHOLOGIST

z._..,.,, �&. \ ...,.,

EXPOSURE DATA SHEET- LARGE ANIMAL EXPOSURES

ANIMAL TATTOO #: ____ J_�_- _1{�L _____ Verified by (Initials):�

EXPOSURE DATE: __ _.fu.I_,_30:.J/--'"1-'-/ __ JULIAN DATE : -----''j'-'-1"'?---''1_:)...:=_ ___ _

STUDY DIRECTOR:�J�.F�-�e�cdhrrn�e�r�-------------------------------

AEROSOL SCIENTIST: __ M�.D�.JHllo�o�v�e�r�------------------------------

EXPOSURE SYSTEM OPERATOR: ______ ������ ��� �-------------------PROTOCOL NO. FY91-026 PROTOCOL TITLE: Mechanisms of

Radiation-Induced Cancer

COST CODE: __ �4�07Ll�----- PROJECT TITLE: Mechanisms of Radiation-

Induced Cancer

TOXICANT: _______ 2_3�9P�u�1 _6_9�Yb�---------------------------------

METHOD OF EXPOSURE: [INHALATION_X_ INSTILLATION __ INTRAVENOUS_

OTHER·-------------------------------------

EXPERIMENT#: 5�]�-0D!

SPECIES: Beagle Dog

ANIMAL #: 00 (

WEIGHT (kg) '---47-'---'-- '1-'---- SEX: �

COMMENTS•---------------------------------------------------

xc: Medical Records [Green copy] Mr. E.B. Barr Study Director

1548C

H Of RAO; C I R TIUN I 11M

F v J 1 -fill: 4 1

Procedures

Rigid Bronchoscope

Flexible Bronchoscope

Photographs

Visual Findings

RIGHT

Diagnosis

Clinician

INHALATION TOXICOLOGY RESEARCH INSTITUTE

BRONCHOSCOPY REPORT

Other

So

Bo

LEFT

WHITE- CENTRAL RECORDS CANARY CLINICAL PINK PATHOLOGIST

Route

PHYSICAL EXAMINATION (AN)

( ,�\\ (Short Form) W.0 •. _"-/ "-1 #=..)._.'f'-':).._ __

Tattoo Number I SC/'6 C- (N-Normal) (A-Abnormal)

A. Date 7-tb-'i I B. Weight 7 (p W !1111 c. Height (Shoulder) __ ._

D. Body Temp. (rectal ).lQQ._.j_ E. Pulse Rate (femoral) /O'i ..

f. Resp1�at1on (rate/min.)� G. General Condition:

1. Comatose 2. Poor 3. Fair

4� c::2::::_ Excellent �

COMMENTS :

Technician

1. Attitude 2. Conformation 3. Hydration _ 4. Nutritional status _ 5. Superficial lymph nodes _

6. Membrane color 7. "Skin and ears 8. Eyes 9. Musculoskeletal system

10. Respiratory system 11. Cardiovascular system 12. Alimentary system 13. Urinary system 14. Genital system IS. Nervous system 16. Endocrine system 17. Teeth and gums

Clinician

./

PHYSICAl EXAMINATION (AN) (Short Form) W.O. (\ '1 J 50 ;?.

Tattoo Number IS'--\ 8C (N-Normal) (A-Abnormal) A Date')o ;;;> 51 "\/8/'lo 1. Attitude •

2. Conformation B. Weight] 'b 00 gm 3. Hydration

c Height (Shoulder) __

._

4. Nutritional status _

•

5. Superficial lymph nodes _ D. Body Temp. (rectal )J£.Q.._l 6. Membrane color

E. Pulse Rate (femoral) 1.:2 0. · 7. ··skin and ears F. Respiration (rate/min. l..3Q\ �: ����uloskeletal system G. General Condition:

��: �:��J�!�����:�·�;�tem 1. Comatose 12. Alimentary system 2. Poor 13. Urinary system 3. Fair 14. Genital system

COMMENTS:

15. Nervous system t 16. Endocrine system 17. Teeth and gums

NEW MEXICO DEPARTMENT OF AGRICULTURE

VETERINARY DIAGNOSTIC SERVICES 700 Camino de Salud NE Albuquerque. New Me�ico 87106 Phone (505) 841·2576

Page: 2

9002061 1541T 9002062 1542B

9002063 15428

9002064 1542T

9002065 15438 9002066 1544A 9002067 1544B 9002068 1544S 9002069 1544T

9002070 1544U 9002071 1545T 9002072 1546A 9002073 1546B 9002074 1546C 9002075 15460 9002076 1546E 9002077 1546F 9002078 1546G 9002079 15468 9002080 1546T 9002081 1547A 9002082 15478 9002083 1547T 9002084 1547U 9002085 1548A 9002086 1548B 9002087 1548C

9002088 15488 9002089 1548T

9002090 1548V 9002091 1550B 9002092 1550T 9002093 1551C 9002094 15518 9002095 1551T 9002096 1552A 9002097 1552B 9002098 15528 9002099 1552T 9002100 1552U 9002101 1553A 9002102 1553B 9002103 1553S 9002104 1553T

I :640

I: 160 1:160

1:160 1:40 I :80 I :80 I :20 I :20

I :40 I :40 I :1280 I :80 1:40 I :640 I :1280 I :640

I :160 I :80

1:160 1:40 1:320 I :40

I :80 1:40 1:40 I :40 I :640 I :80

I :640 I :640

I :320 I :1280

I :640 1:320 I :40 I :1280 I :640 I :160 I :80 1:160

1:80 I :80 1:160

Case: Species: Owner: Animal Name:

90-02025 Canine

Lovelace P090005110006

16 .Lj'l-c /1-lcJ

INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT

HISTORY (Reason for submission)

r;'{fi \ DATE SUBMITTED 1;-;.j;.s-/8 X REQUESTED BY

0 URINALYSIS COLLECTION METHOD

Compression ___________ _

Catheterization __________ _

Cage _ ____________ _

Other _ ____________ _

CHEMISTRY (chemstrip·Bl Sugar ____________ _::m"'g/-"'dl Albuminl ___________ _:::m!!!.g/:::dl

OMICROSCOPIC COMMENTS· DIRECT

Hemoglobin ERY/ug CYTOCENTRIFUGE Acetone ____________ _

Bilirubin _ ___________ _

Urobilinogen __________ _:_m"g'-"'/ d l

Occult blood __________ ER"-Y'-'-/""ug

Nitrite Sp Gr -------------pH ________________________ _

Color _____________ _

Turbidity ____________ _

MICROSCOPIC WBC __ _ _ _ _ _ _ _ ___ __

ABC _ _ __ _ _ _ _ _ _ _ _ _

Casts Hyaline'------------­

Granular·-------------

WBC or ABC ___________ _

Other ____________ _

Bacteria ____________ _

Renal Cells-----------­

Crystals-------------

CENTRAL RECORDS

TECH/PATH Date

::¢i'���;�EOUESTED paraSites 0 Trypsin OOther Procedure Used ______________ _

Results

TECH/PATH-/f-1.,/;_-f/-�--- Date//"'

) ,. l

"· . . .. ·-·- _____ ___.__:_:-c.�. .. -�--·-

OBSERVATION

IY: -:r 11.J. s eoo MIIW. Ill: LdieR 1.51../2 Date: IJ,/; y/gq f9.3</:r

Tl1M _LU:fu_ cj IKV� wtM­

/5'-/�A iS'/� 6

.15'-18c. /5'-/g s,

· IS'-I'i!T 154'E v

-/-w-nx OVJ !t)ujs-7 (F9321R) M ..),�?? o_:s. �OSj70?..ct MNo-i+a c..�- Wij w-?u /JoY

ka..ttl � �- We wtd /zaw. � --Jeccd J/.e -1-e.:vte cl lo _foe.e 11 � ..ho ("� /v

[/ !: !J (} ' jJ � J/.L ihvt je ceJ

JW3 /s,J v/iJJ��J/31?

C!;1s<�o . ·

INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT

HISTORY (Reason for submission)

REQUESTED BY DATE SUBMITTED // p:2)g' 1

0 URINALYSIS COLLECTION METHOD

Compression ___________ _

Catheterization ______ ____ _

Cage _____________ _

Other _____________ _

CHEMISTRY (chemstrip-8)

Sugar ____________ _::m:!!g/�dl

Albuminl ___________ __:::m:t_g/�d l

OMICROSCOPIC COMMENTS DIRECT

Hemoglobin ERY/ug CYTOCENTRIFUGE

Acetone ____________ _

Bilirubin ___ _________ _

Urobilinogen __________ _:m::og�/dl

Occult blood _________ _:.Ec:.RY"-/"-'- ug

Nitrite Sp Gr -------------pH ________________________ _

Color _____________ _

Turbidity ____________ _

TECH/PATH

MICROSCOPIC ����;�EOUESTEO �Parasites

Date

OTrypsin OOther WBC _ _ _ _ __ _ _ _ _ _ _ _ Procedure Used ______________ _

ABC _ __ _ _ _ _ ___ __ __

Casts

Hyaline ____________ _

Granular ____________ _

WBC or ABC ___________ _

Other-------------

Bacteria ____________ _

RenaiCel!s -----------­Crystals -------------

CENTRAL RECORDS

Results

TECH/PATH------'a_.w.�"--- Date 1//:t:J� I�

' ------ --- --'----

OBSERVATION

IY: T&i/ s pua MIIIAL Ill: /$ L/ 8r Date: 11 In h1 Rr.317 }

l fl,s J-:ecc,/) lie �M �tux- pC/)_1/VJ.H' -/r"'- /J_ai!VYI�

/JWj ./ICI/U .f:lc�.-u::Liet CaJ�'J. :J/"' Jerc:x__( >{)arnj2h..

wa.1 /cu:t_,'" .--t_� .Ju ?UM _ljYI 'Me -!?a:1,aut-cJ /JLjc/'..£ lk /Uj)l7'.i:- {'CvJ'?'U ftu,t --/Lc. t-UOLJ {]frd

k lh h/17/YLd , /Ja d lu �-" _L(_w� -ftlcci'ta

f].J,A-£ � uJ&u rfi/1-<J /!aLL £ir ;/) oL< � f'c1-� ?!/( wiD 11crl frt?( i .,A;c. JYJ a t

'f}LUJ 1:Jo-r/� -t . He t vu ( -:1'7 av-e _/'uo -/<' <C<-(

/U #.:2 (; ct A-·Y1 d tA/a &J.

/ . !Jr/ CJ. j) It t�cu /U- - kd /e rc:u /0-uJ;U c 1 s Y g C"/7 g c;Ja:it

/�� ��93�

HOSPITAL ADMISSION and DISCHARGE

Kennel HIO

l. 2.

3.

4.

5.

6.

7.

8.

9. 10.

Temp__l6_l!__pulseJ1l.lResp__lk_)leight 5: CJ

II.

!2.

13.

!4.

15.

1\n r\ ' 16.

occ )('CJ , ercc:s.siO(') 17.

Attitude Confonnotion Hydration tlutritional status Super. lymph nodes Hembrane co 1 or Skin and ears Eyes

tlonn. Abnorm.

Musculoskeletal sys. Respiratory sys.

-

Cardiovascular sys. Alimentary sys. Urinary sys. Genital sys. Nervous sys.

· Endocrine sys. Teeth and gums

Julian Date

c�>,3::G l'J'I.!x>i

19 't{.J

l�q'.l[':':

1)1 1(1;(,c

�•\ S � Qli?r, 1'

ih9Wh <tio9

zc,1,o

i-i2,(/

CLINICAL CHARo

General Comments:

\)L\SC

Appe tite

-�

-\

c=

Tn

7., ?

F'

r·, 7

r-

Bowels Urine T p R COMMENTS

{\

i \

lv

A �·

(l ,, �\

u "?.

Ito\�

hnillJ I iOD btJi) lP

(•,

C?c/Gu.� -suDM•<+-> :\ i'\<-< �"' l,, \c.,\ !d� "''""-::_m (, � (' """"- \

�) k. ,, -\-en,,, 1 e ,,, () () (_.--., �� '"' <:·lnr\ )-<,f",\\ -<_ . "'' . .

r\,,e> n -� M\ ,j I�.H \c, , . . f h. J '),) ,, ,, ' i!U( tit (,

L-u.;k.� "''" ,\ r ,A,,, ' ,A, · � "''� (' \ \ A A. I..- )

A)_ i / j· -

7 7 "'.:::=<--.:.... (- 1<'0 'v\ \_·"t" f'tY•,.-l <r>-\-/cX:P._Ck-rf

') ":Jt ' ., <: c\ ; � i"A" th<). '

Jmr: 1("{f(':f"\(Ghf r"- i..J.A-J }1wir,,h;.1 �· I�- �.:-\• .;J,d

tO<;J iJ'�v-._ � �A. c.,,k nv0rntoh-t 11,-

(S Loof:c � I' :; . .t/, ..-/,'/h.,Y>. / ,;, te. /;;;;I:\ !We< .;,,.,,,� J /'VL

./. � ! 7/ ,/ /l.·J f: u.

lrm -,,..,,.,"""' -:>.rl-< U Ia� -I- '.., ?.ld< '� -�<SC/r.''-"-<-""' 1"2>-v 1::" c:...- 7T9r

"'"� .�'] !'r· ' ()(I , , _ _ .(),, ;a .. ,

l ?"

ABBREVIATIONS: Appetite: F=fau. G-good, P-poor, 0-none. Bowels: N-normal, D-diarrhea, DB-diarrhea with blood, 0-no feces. Urine: N-normal, A-abnormal, 0-none.

ORDER SHEET

General C omments:

\ �l� c c

IJ u 1 i a n1 l<ork Order

Date 1 ORDER Clinician Issued Conoleted

:C,":£(' ChL/ (L'-"''\ \", \1.,\ C."'�(( v

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' ' ' ' ' ' ' ' I I '""'"""'�"'0"""'-<"' I I ... ,..,.,. .... • • • • •M I I O-< lnMC> ... ON ' ' " ' '

' ' ' ' ' ' I l.l..:l.l .l..:l.l.l I I PIJtl.l.l..:l .. u:u:O P CI I I '-'-'-'-'-PO'-..'-'-.'-. I I CICICI::>=>'-'.CICICICI I I:CI::I:..,...,CICI:C:ICil!:il!:

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' ' ' ' ' ' ' ' ' '

' ' ' '

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j

INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT

HISTORY (Reason for submission)

REQUESTED BY DATE SUBMITTED 1/,k,/rq (J6?) 0 URINALYSIS

COLLECTION METHOD Compression ___________ _

Catheterization _ _________ _

Cage _____________ _

Other _____________ _

CHEMISTRY (chemstrip·B)

Sugar ____________ c:m::! g/'-"dl

Albumin, ___________ __:::mq /,_ de:l

0MICROSCOPIC COMMENTS DIRECT

Hemoglobin EAY/ug CYTOCENTAIFUGE Aceto ne ____________ _

Bilirubin ____________ _

Urobilinogcn __________ _::m::!g/'-" dl

Occult blood _________ ___.:::ER.:._Y� /u::.'!g Nilnle ------------­

Sp G< -------------

pH ____________ _

Colore _____________ _

Turbidity ____________ _

MICROSCOPIC WBC. _ _ _ _ _ _ _ _ _ _ _ _ _

ABC _ _ _ _ _ _ _ _ _ _ _ _ _

Casts

Hyaline, _______ _

Granular ____________ _

WBC o< ABC. _________ __ _

Othe<·--------------

Bacteria ____________ _

Renal Cells ___________ _

Crystals ____________ _

CFNTRAL RECORDS

TECH/PATH Date

jl(FECAL TEST REQUESTED J;{Pacasctes 0 Trypsin OOther

ProcedureUsed• --------------­

Results

TECH/PATH ____ ,L(\;.,Ow__ oate «h/S?'j

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INHALATION TOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT

HISTORY {Reason for submission)

REQUESTED BY DATE SUBMITTED 9,/i,/rt:j r; 'f'f)

OURINALYSIS COLLECTION METHOD

Compression ___________ _

Catheterization __________ _

Cage _____________ _

Other _____________ _

CHEMISTRY (chemstrip·8)

Sugar ____________ .::.m::!!g/:e:dl

Albumin ___________ __:::mg�/dl

OMICROSCOPIC COMMENTS· DIRECT

Hemoglobin ERY/ug CYTOCENTRIFUGE

Acetone ____________ _

Bilirubin ____________ _

Urobilinogen __________ _::m�g:::.:i dl

Occult blood _ ________

___:::ER�Y:c_/:::!ug

Nitrite ------------­

Sp. Gr. -------------

pH _______________________ _

Color _____________ _

T urbidity ____________ _

MICROSCOPIC

WBC _ _ _ _ _ _ _ _ _ _ _ _ _

RBC _ _ _ _ _ _ _ _ _ _ _ _ _

Casts

Hyaline ____________ _

Granular ____________ _

WBC or RBC. ___________ _

Otherr--------------

Bacteria ____________ _

Renal Cells -----------­

Crystals -------------

:ENTRAL RECORDS

TECH/PATH Date

illfF ECAL ../'rEST REQUESTED �Parasites

Procedure Used ______________ _

0 Trypsin OOther

Results

TECH/PATH ___ _,cv�--- D a •e 9/r i-?7

OBSERVA Tl ON

BY: 68�a� ANIMAL IIi: C1 Date: 89J33 SjJ I ]89

For -he.Dltmen+ o+ Gi.urcltix Co.ni� lS'-1'8"\/

pV.Qse pla__u_ +hese pu.ppw:> on '/z_ -fa.ble+

0 4' me.+ ron\ cla<o /e. ( F-lo. j'j I ) p, 0. s I 0 X s d

+he.n re. -lest t'e Co.. I So.. m ple. .

-OBSERVATION

:;MAL ,; i�4!0 P��r Date: 8'"1 �35 '8 12.3/8"\

154'8 f\ \5�'6 2 ISL\-8 C \st48S

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()<'. -gq�35

INHALA .. -.. tOXICOLOGY RESEARCH INSTITUTE URINE/FECAL REPORT

HISTORY (Reason for submission)

/ \ ( :?-Jd)

REQUESTED BY DATE SUBMITTED $,/1'1/dCj

OURINALYSIS COLLECTION METHOD

Compression ___________ _

Catheterization __________ _

Cage _____________ _

Other _____________ _

CHEMISTRY (chemstrip·BI Sugat ____________ .::m:l!g/.:!:dl Albumint ___________ __:.::m�g/d l

0MICROSCOPIC COMMENTS DIRECT

/iea-l::ed SID x Sd

metronidazole.. Gt arcb."a. funIs

Hemoglobin ERY/ug CYTOCENTRIFUGE·

Acetone __ __________ _

Bilirubin ____________ _

Urobilinogen __________ _::m:::!g�/dl

Occult blood ________ _ _:_ERc_Y:.:_ i::.u g

Nitnte -------------Sp Gr ---------------pH __ __ _ _ _ _ _ _ _ _ ___

Color _____________ _

Turbidity ____________ _

MICROSCOPIC WBC __ _ _ _ __ _ _ _ _ _ _

ABC _ __________ ___

Casts Hyaline _________ ___ _

Granular _ _ __________ _

WBC or ABC. ___________ _

Other ____________ ___

Bacteria ____________ _

Renal Cells ___________ _ Crystals -------------

TECH/PATH Date

il!FECAL .., 1-EST REQUESTED JffParasites 0 Trypsin DOther

Procedure Used _ _____________ _

Results

TECH/ PATH---'aa_...._ ___ Oatet-i&.l,<hca.JI'./-/-'l.U';t__

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::AGE

PRO'IOCDL FY91-026 MECH,NISMS 0:1F R�INDUCED CANCER

ASSIGNED AS •) • ;11 201· \ Ju l y 25' t·:.·:11)

TA.TTOI�I 1/MI::THOT '"' ; V M_C3TCD "·/M_TITLE

1':"·41 T :::·::' 14':"· F 4(i7l RADIA.TION INDUCED CANCER

1'54.:.C: :::·."I/ 1':"·4 M 4U71 RADIATION INUUCEO CANCER

1'54.:3 :::·:'/1':·4 F 4(1{ 1 F.AO!AT!ON INDUCED ':ANCER

1':·44_.-l. ::::·� .. ! :.-:, M 4(•71 f'."ADI�TION trJOtXED (A.N(:;::F\

1'544E: .::·;I/ 1'5 :: M 4071 RADIATION INDUCED CA;J·:;:s·

��443 :;:·::/ 1 ':• :, F .�(·7! F:40i.:OTI':'N !NDUCEJ ·� ;.r�·: F�: 1'544T :::·:'1/15":0 F 4(171 RAOIATII)N INDUCED •:AN(EF."

1544U :3'''/1�:, F 41)71 RAD!ATION INDUCED ( ANCER

1545T :::·;1/1..:.:3 F 4071 RADIATION INDUCED CANCt::R

1546A :::·:1/1-::·5 M 4071 RADIATION INDUCED CANCER

1'546C 8'?/ 165 M 4(.171 RADIATION INDUCED CANCE.R

1'54..;.3 :::·;1/1<.:·5 F 41)71 RADIATION INDUCED CANCER

!'546T ::::·:'/ltE� F 407 1 RADIATION INDUCED CANCER

1'54 7A :::·?/16:3 M 4071 RADIATION !NDUCED CANCER

1'547S :3'?/168 F 4071 RADIATION INDUCED CANCER

1'547T :39/168 F 4071 RADIATION INDUCED CANCER

1547U :39/168 F 4071 RADIATION INDUCED CANCER

1'548A ::::o;Jf t:::.:. M 4071 RADIATION INDUCED CANCER

15488 :39/t:S.:: M 41)71 RADIATION INDUCED CANLER

t'54:::c ::;9;1:::2 M 41)71 RADIATION INDUCED CANC.ER

1548S 89/t:::tz F 4071 RADIATION INDUCED CANCER

1'543T ::t·:;lf1SZ F 4071 RADIATION INDUCED CANCER

1'543V 89/18Z: F 4071 RADIATION INDUCED CANCER

15�0B 8'?1!';>1 M 4071 RADIATIIJN INDUCED CANCER

1551C :39/1'?6 M 4071 RADIATION INDUCED CANCER 1551S 8"?/ 196 F 4071 RADIATION INDUCED CANCER

I5'5IT 89/1'?6 F 4071 RADIATION INDUCED CANCER

1!552A 89/ZOO M 4071 RADIATION INDUCED CANCER

155Z:Et 89/Z:OO M 4071 RADIATION INDUCED CANCER

I'5'-52S :3:9/201) F 4071 RADIATION INDUCED CANCER

I552T 8'?/200 F 4071 RADIATION INDUCED CANCER

1552U ,39/200 F 4071 RADIATION INDUCED CANCER

155:3A 89/206 M 4071 RADIATION INDUCED CANCER

1'-5!5:3S 89/ZOO F 4071 RADIATION INDUCED CANCER

I556A 89/342 M 4071 RADIATION INDUCED CANCER

t556S 89 /342 F 4071 RADIATION INDUCED CANCER

15!57S 89/3!53 F 4071 RADIATION INDUCED CANCER

PAGE l

PROTO<DL: FY91-026 MECHAN I Sl"'S OF RADIATII)N !NDUCED

ASSIGNED AS OF qt.:(ll:. (J '.l! y .::.5.

TATTOO VME.THOTE SE:: VM_(STCD

1'5.:-1.:1, ::::3/ �:4(! M 41)71

1':·.:-H.: :::·:·; �:41) M ·•071

1 ':.:.4C :-:-: ;;-.<) M -V•71 1'5.:- 40 :=:;:::/ ::4(1 M 4(171

1 '5.:.4:; :::::::; ::4•) F 4(•71 l':.:.':·A ·::::::I �'4:::: M -H)ll t5.:5s :;:·:: / �:4::: F 407 1

t5.:5T ::::::::; �.4:� F 4011

t5.:5u :3:3/ �:4:3 F 4(1'i 1

1 !526A ·:;:·;1/t)l)l,:. M 4(171

t5z,.=.s :::·;1/l)(l.,:. F -l071

1526T :;:•,1/(H)Ii, F 4-071

1'5.::-.:-u :39/•)('1;. F 4071

15::'?A :=:·=1;1)2:� M 4071

1'52'i)T :;;·::.;1)23 F 4071

1530A :::;·;.;o::::r.:. M 407 1

15:305 :3'?102:6 F 4071

153tH :39/0:Z:o F 4071

15'31A :::;<:;�;o:::;o M 4-071

15.31B :39/0:30 M 4071

15328 ·::·_;.;()41) M 4071

1532C 891040 M 4071 1�33A 89/078 M 4071

15338 :3'?/078 M 4071

15'33C 89/078 M 4071

15335 $9/078 F 4071

1533T 89/078 F 4071

1�34A 89/099 M 4071

15348 89/089 M 4071

1'5:34C 89/089 M 4071

U53!5A 891114 M 4071

153!58 :39/114 M · 4071

1�3!55 s·n114 F 4071

1!53!5T $9/114 F 4071

1536A 99/114 M 4071

1!5365 99/114 F 4071

1536T 39/114 F 4071

15:36U 99/114 F 4071

15378 89/12:'3 M 4071

1537T 39/123 F 4071

15388 89/134 M 4071

1!5:39A 39/140 M 4071

1'539G 8'?/140 M 4071

15.3'?D 89/140 M 4071

15:39S 89/140 F 4071

1'5-40A :39/141 M 4071

15406 :39/141 M 4071

154t)S 8'?/141 F 4071

1 '540T 89/141 F 4071

CANC ER

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TABLE 2 C ( C j)-

Mechnisms or Radiation Induced Cancers: I .

Assignment of Dogs for Studies Other Than Immunology

Malrlfattoo Blrthdate Maleffattoo Blrthdate

1491 B 87133 1538 B 89134

1494 D 87143 1539 A 89140

1495 c 87147 1539 D 89140

1506 D 88004 1546A 89165

15078 88032 1546 B 89165

1508 A 88043 1546 c 89165

1510A 88081 1546 D 89165

1513 B 88120 1546 E 89165

1513 c 88120 1546 F 89165

1514 B 88133 1546 G 89165

1518 c 88261 1547 A 89168

1518 D 88261 1548 A 89182

1518 E 88261 1548 B 89182

1518 F 88261 1548 c 89182

1521 A 88279 1550 B 89191

1521 B 88279 1551 c 89196

1522 B 88323 1552 A 89200

1523 A 88330 1552 B 89200

1523 B 88330 1553 A 89206

1524 A 88340 1553 B 89206

1524 B 88340 1556 A 89342

1524 c 88340 1557 A 89353

1525 B 88348 1558 B 89354

1532 c 89040 1558 c 89354

1533 c 89078 1560A 90055

1534 A 89089 1560 B 90055

1534 B 89089 1565 A 90163

1534 c 89089 1565 B 90163

1534 D 89089 1567 A 90270

1534 E 89089

TABLE I

Mechanism of Radiation Induced Cancers: Assignment of Dogs for Studies Other Than Immunology

[emal!l[attoo Blrthdatr: Femaleffattoo Birthdate

1498 u 87180 1525 s 88348

1501 T 87227 1529T 88023

1502 s 87228 1537 T 89123

1508 T 88043 !541 T 89145

1509 s 88062 1542 s 89154

1509 T 88062 1545 T 89163

1509 u 88062 1546 s 89165

1511 s 88088 1546 T 89165

1511 u 88088 1547 s 89168

1512 s 88111 1547 T 89168

1512 u 88111 1547 u 89168

1514 T 88133 1548 s 89182

1514 v 88133 1548 T 89182

1515 T 88141 1548 v 89182

1515 u 88141 1550 T 89191

1515 v 88141 1551 s 89196

1516T 88146 1551 T 89196

1516 u 88146 1552 s 89200

1517 u 88160 1552 T 89200

1521 s 88279 1552 u 89200

1521 T 88279 1553 s 89206

1521 u 88279 1553 T 89206

1522 s 88323 1553 u 89206

1522 v 88323 1556 s 89342

1522 w 88323 1557 s 89353

1523 s 88330 1560 s 90055

1523 T 88330 1560 T 90055

1523 u 88330 1565 s 90163

1523 v 88330 1567 s 90270

1524 s 88340

INTEROFFICE MEMORANDUM January 22, 1991

TO: Dr. F. F. Hahn

FROM: Dr. B. A Muggenburg �

SUBJECT: Mechanisms of Radiation Induced Cancer: Assignment of Dogs for Studies Other than Immunology

The dogs listed in the attached tables are available for this study for exposure

after January 1, 1991. We have assigned equal numbers of males (59) and females (59).

These dogs were born from May, 1987 to September, 1991. This allows for an exposure

window beginning now until October, 1991. Ten extra dogs were assigned to allow for

the exclusion of dogs that receive too much or too little plutonium aerosol.

BAM: pis WI Attachments

XC: Dr. C. H. Hobbs Dr. D. G. Thomassen Dr. B. B. Boecker Dr. N. F. Johnson Dr. K. J. Nikula Dr. D. G. Burt