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CardioSense3DIntroduction
H. Delingette
Intermediate Evaluation of the CardioSense3D Research Action
Agenda of the day
Start End Topic Speaker
9h30 9h55 Introduction of CardioSense3D ( with 5mn questions) Hervé Delingette
9h55 10h25Research Activity of the Asclepios Team within CardioSense3D
( with 5mn questions)Hervé Delingette
Maxime Sermesant
10h25 10h55Research Activity of the Sisyphe Team within CardioSense3D
( with 5mn questions)Michel Sorine
10h55 11h10 Coffee Break
11h10 11h40Research Activity of the Macs Team within CardioSense3D
( with 5mn questions)Dominique Chapelle
11h40 12h10Research Activity of the Reo Team within CardioSense3D
( with 5mn questions)Jean-Frédéric
Gerbeau
12h10 12h30 Perspectives of CardioSense3D ( with 5mn questions) Miguel Fernandez
12h30 13h45 Lunch Break
13h45 16h00 Discussion with the evaluation committee All
16h00 17h00 Discussion within the evaluation committee
Introduction to CardioSense3D
•Scientific Objectives and Positioning
•Partnership and organization
What is CardioSense3D ?
An INRIA Large Initiative Action on cardiac modeling :
• Started (officially) in May 2005
• 4 ans duration (evaluated after 2 years)
• Transversal to 4 INRIA project teams :
– ASCLEPIOS (Medical Image Analysis and Simulation) N. Ayache
– MACS (Biomechanics and Numerical Analysis) : D. Chapelle
– REO (Fluid Mechanics) : J-F. Gerbeau
– SISYPHE (Contrôle and Modeling) : M. Sorine
• Supervisor : H. Delingette,
• Co-Supervisor : M. Fernandez
Cardiac data
solid mechanics
Clinical applications
Diagnosis
Therapy planning
blood flowPersonalization
electro-physiology
perfusion & metabolism
CardioSense3D Research Topics
Cardiac modeling
anatomy
Objectives
• Build a patient specific heart simulator
• Estimate the parameters of this model from observations of the
cardiac function,
• Develop clinical applications (Cardiac Resynchronisation
Therapy, radiofrequency ablation,..).
Propose models having a low number of parameters
State of the art
Computational Cardiac Models
• ElectroPhysiology : Noble et al. (Oxford),
S. Panfilov et al. , O. Dössel (Karlsruhe),
Y. Rudy et al. (Wash. Univ. St Louis),
Colli-Franzone (Univ. Pavia)
• Flow-Biomechanics : C. Peskin (NYU),
Quarteroni (EPFL),…
• Electro-mechanics : Peter Hunter et al.
(Physiome project; Auckland); Andrew
McCulloch et al. (UCSD)
anatomy
electro-physiology
solid mechanicsblood flow
perfusion & metabolism
Cardiac modeling
State of the art
Cardiac Image Analysis (Geometrical approaches)
• Elliott McVeigh et al. (JHU+NIH)
• D. Rueckert et al. (Imperial College) and R. Razavi et al.
(KCL + Guy’s hospital)
• Magnin et al (Creatis), Duncan et al (Yale), Axel and Metaxas
(Rutgers & NYU), Frangi et al. (Univ. Pompeu Fabra), P. Shi
(Hongkong Univ.)
Cardiac data
State of the art
Therapy planning
Clinical applications
Diagnosis
Therapy planning (Generic Models)• D. Noble (Oxford)
• A. Mc Culloch (UCSD)
• O. Dössel (U. Karlsruhe) & F. Sasche (U. Utah)
Positioning of CardioSense3D
•Integrate/Couple 4 physiological phenomena :Electrophysiology, Contraction/Relaxation Mechanics,
Arterial Circulation, Perfusion
•To propose models having a low number of parameters in order to estimate them from clinical data.
•Develop clinical applications (CRT, RF Ablation) based on personalized models
CardioSense3D : Academic / Clinical / Industrial Partnership
Physiology/Control• Sisyphe/Sosso, INRIA
Numerical Analysis • Macs, INRIA
• Reo, INRIA
• Geometrica, INRIA
• Gamma, INRIA
• Univ. de Nantes
• Pzlen Univ. (Czech Rep.)
• LIRMM (Montpellier)
Imaging/Simulation• Asclepios, INRIA
• UCL / King’s College (London)
• Creatis, CNRS
Clinical Sites• Guy’s Hospital (London)
• NIH (Washington)
• HEGP, U678 (Paris)
• Hopital Henri Mondor (Créteil)
• Sunnybrook Health Sciences Center
• InParys, Clinique George Bizet
• Hopital Bicêtre + Paris XI U. +INSERM (Paris)
Industrial Partners• Philips Research France
• ELA Medical
• (Siemens)
First Circle Members of CS3DTeam ASCLEPIOS Team MACS Team SOSSO2 Team REO
N. Ayache D. Chapelle M. Sorine J-F. Gerbeau H. Delingette P. Moireau Q. Zhang M.A. Fernández M. Sermesant M. Vidrascu Y. Papelier M. ThirietJM. Peyrat J. Sainte-Marie T. M. Laleg I. Vignon-Clémentel F. Billet E. Phe K. Djabella M. Boulakia D. Lepiller R Djafri N. ZemzemiT. Mansi A. Illanes-Manriquez M. AstorinoN. Toussaint C. Grandmont
•Sophia-Antipolis
•Rocquencourt
Two different INRIA Research Units :
INRIA Support
Recruitment of :
• P. Moireau (Détachement X-Corps des Telecoms) in 2005
• 4 Phd Thesis :
– R. Chabiniok MD (Macs) from Sep. 2007 bourse Cordi
– M. Astorino (Reo) from Janvier. 2007 bourse Cordi
– F. Billet (Asclepios) from Oct 2006
– R. Djafri (Sisyphe) from 2007
• 3 Engineers :
– M. Alba (Macs) 2005-2006 Ingénieur Associé
– E. Phe (Macs-REO) 2006-2008 Ingénieur Associé
– N. Toussaint (Asclepios) : 2006-2008 Ingénieur Associé
External Support
National Scholarship :• PhD of N. Zemzemi
Philips Medical Systems Paris (Suresnes):• PhD of D. Lepiller (Asclepios)
ELA Medical :• Post-doc of M. Boulakia (Reo) and Post-doc of G. Ebrard
Siemens Corporate Research• PhD of JM Peyrat
European Health eChild• PhD of T. Mansi
European RTN HaeModel• Phd of N. Diniz Dos Santos
Industrial contracts • PhD of M. Laleg and K. Djabella
Software
Current Development based on 3 software packages :• LifeV (Reo) (www.lifev.org) for CFD and electrophysiology
• OpenFEM (Macs) (www-rocq.inria.fr/OpenFEM/ ) for FEM continuum mechanics
• Mips and MedInria (Asclepios) for medical image analysis + simple models for electrophysiology and soft tissue deformation (migration on SOFA) (www-sop.inria.fr/asclepios/software/MedINRIA/)
Software developed within CardioSense3D :• CardioViz3D (Asclepios)
• Heartlab (Macs)
Dissemination Activity
• “Digital Heart” DVD (20mn)
Auteurs scientifiques : Dominique Chapelle, Hervé Delingette, Miguel Fernandez, Philippe Moireau,
Maxime Sermesant
Dissemination Activity
• “Digital Heart” Movie
• Public release of Software (CardioViz3D) and database (DTI atlas)
• Involvements in Conferences (NIH-INRIA workshop)
• General Audience Articles (La Recherche, Ercim News)
Dissemination Activity
• “Digital Heart” DVD
• Public release of Software (CardioViz3D) and database (DTI atlas)
• Involvements in Conferences (ISBI’07, NIH-INRIA workshop)
• General Audience Articles (La Recherche, Ercim News)
• CardioSense3D seminars with Paris V university
Dissemination Activity
• “Digital Heart” DVD
• Public release of Software (CardioViz3D) and database (DTI atlas)
• Involvements in Conferences (ISBI’07, NIH-INRIA workshop)
• General Audience Articles (La Recherche, Ercim News)
•CardioSense3D seminars with Paris V university
•Organisation of workshops (summer school) and conferences (FIMH’09 in Nice)
•Apple ARTS Award
Agenda of the day
Start End Topic Speaker
9h30 9h55 Introduction of CardioSense3D ( with 5mn questions) Hervé Delingette
9h55 10h25Research Activity of the Asclepios Team within CardioSense3D
( with 5mn questions)Hervé Delingette
Maxime Sermesant
10h25 10h55Research Activity of the Sisyphe Team within CardioSense3D
( with 5mn questions)Michel Sorine
10h55 11h10 Coffee Break
11h10 11h40Research Activity of the Macs Team within CardioSense3D
( with 5mn questions)Dominique Chapelle
11h40 12h10Research Activity of the Reo Team within CardioSense3D
( with 5mn questions)Jean-Frédéric
Gerbeau
12h10 12h30 Perspectives of CardioSense3D ( with 5mn questions) Miguel Fernandez
12h30 13h45 Lunch Break
13h45 16h00 Discussion with the evaluation committee All
16h00 17h00 Discussion within the evaluation committee
Cardiac data
solid mechanics
Clinical applications
Diagnosis
Therapy planning
blood flowPersonalization
electro-physiology
perfusion & metabolism
CardioSense3D Research Topics
Cardiac modeling
anatomy
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