Author Index - Journal of Immunology · Author Index Abbott, Derek J., 1458 Adams, William C., 1721...

Author IndexAbbott, Derek J., 1458Adams, William C., 1721Adelsberger, Joseph W., 1625Adler, Adam J., 1524Admyre, Charlotte, 1969Adorini, Luciano, 1559Agapov, Eugene, 1438Aggarwal, Bharat B., 1926Ahmed, S. Ansar, 1776Ahn, Kwang Seok, 1926Akinci, I. Ozkan, 1834Ala-Houhala, Ilpo, 1988Albrecht, Imke, 1825Al-Garawi, Amal, 1740Almo, Steve, 1730Alpdogan, Onder, 1669Alter, Galit, 1625Altfeld, Marcus, 1625Amigorena, Sebastian, 1489, 1950Amuchastegui, Susana, 1559Andersen, John F., 1497Anderson, Stephen K., 1625, 1751Antonini, Valeria, 1681Apparailly, Florence, 1506Aquilano, Francesca, 1559Arstila, T. Petteri, 1988Arva Tatireddigari, Venkat R. R., 1814Auh, Sogyong, 1960

Baatar, Dolgor, 1996Backlund, Johan, 1431Bafica, Andre, 1497Baker, Christina M., 1834Bakker, Aleida M., 1506Ball, Tanja, 1730Banerji, Aleena, 1901Barrett, Christopher W., 1648Barrio, Marcela, 1950Baseler, Michael W., 1625Bauer, Kristin, 1431Bell, Michael P., 1893Belland, Robert J., 1814Bellmeyer, Amy, 1834Benoıt, Loralyn A., 1466Biragyn, Arya, 1996Bobenchik, April M., 1681Boivin, Marie-Noelle, 1549Bolwell, Brian, 2013Bondu-Hawkins, Virginie S., 1796Borsotti, Chiara, 1669Boyce, Joshua A., 1740Brady, Maya, 1760Brandwijk, Ricardo J., 2005Budinger, G. R. Scott, 1834Bushnell, Timothy, 1616Butcher, Geoffrey W., 1784Byrne, Gerald I., 1814

Cahalan, Michael D., 1586Carrington, Allison, 1475Carrington, Mary, 1625Carter, Christine, 1784Cascalho, Marilia, 1659Castilow, Elaine M., 1648Ceballos, Ana, 1950Cembrola, Katherine M., 1884Chandel, Navdeep S., 1834Charbonnier, Louis-Marie, 1506Chen, Sheng, 1634Chen, Shunle, 1634Chen, Wenhao, 1542Chen, Xiao Xiang, 1634

Chow, Andrew, 1669Claudio, Estefania, 1751Clayton, Linda K., 1681Coadwell, W. John, 1784Colgan, Sean P., 1934Collin, Matthew P., 1595Combaluzier, Benoit, 1825Conchon, Sophie, 1532Connick, Elizabeth, 1979Connolly, John E., 1681Conrads, Thomas P., 1497Cossetti, Chiara, 1559Cote-Sierra, Javier, 1740Coyle, Anthony J., 1740Critchley-Thorne, Rebecca J., 1532Croft, Michael, 1427Czapiga, Meggan, 1693

Dai, Ming-Shen, 1532Dai, Rujuan, 1776Davis, Randall, 2013De Carli, Elena, 1559de Gruijl, Tanja D., 2005Desrosiers, Melanie D., 1884Diao, Jun, 1542Dickinson, Anne M., 1595Dillon, Stephanie, 1979Dion, Carine, 1784Doberstein, Stephen K., 1872Domınguez-Punaro, Marıa C., 1842D’Souza, Michelle, 1979Dubyak, George R., 1913Dyer, Kimberly D., 1693

Eivazi, Araz, 1872Ennis, Francis A., 1988Erard, Francois, 1872Escara-Wilke, June, 1423Ezhevsky, Sergei A., 1872

Fakir, Michael J., 1884Faubion, William A., Jr., 1893Fedorov, Alexander A., 1730Ferry, Nicolas, 1532Fibbi, Benedetta, 1559Filen, Jan-Jonas, 1969Fluharty, Kara, 1864Focke, Margarete, 1730Fontenot, Andrew P., 1979Foster, Barbara, 1693Foster, Paul S., 1693Franchi, Luigi, 1913Francischetti, Ivo M. B., 1497Francois, Moıra, 1549Fraser, Christopher C., 1740Fu, Yang-Xin, 1960Furutani-Seiki, Makoto, 1605Furuuchi, Keiji, 1760

Gabrielsson, Susanne, 1969Gajewski, Thomas F., 1960Galipeau, Jacques, 1549Gallo, Robert C., 1415Garcia, Jessica E., 1825Garrod, Kym R., 1586Geffner, Jorge, 1950Gelderman, Kyra A., 1431Geraldes, Pedro, 1659Giarratana, Nadia, 1559Giordano, Mirta, 1950Gohda, Masashi, 1577Goldstein, Daniel R., 1700

Gondek, Lukasz, 2013Gonzalo, Jose-Angel, 1740Gottschalk, Marcelo, 1842Goudsmit, Jaap, 1721Gould, Aaron, 1438Goya, Inigo, 1740Graf, Beth, 1616Graham, Margaret, 1784Grayson, Mitchell H., 1438Groskreutz, Dayna, 1648Grubin, Jeremy, 1669Grusby, Michael J., 1681Gu, Yue Ying, 1634Guerin, Coralie, 1489Gupta, Naveen, 1855Gutierrez-Ramos, Jose-Carlos, 1740

Hagymasi, Adam T., 1524Hall, Pamela R., 1796Hamid, Qutayba, 1740Han, Wanda G. H., 1506Haniffa, Muzlifah A., 1595Hartl, Arnulf, 1730Hassan, Ihab, 1648Havenga, Menzo J. E., 1721Hedman, Klaus, 1988Heller, Glenn, 1669Hepburn, Lucy, 1784Herrmann, Kai, 1659Higuchi, Morio, 1577Hilkens, Catharien M. U., 1595Hirata, Koichi, 1803Hiratsuka, Hiroyoshi, 1803Hirohashi, Yoshihiko, 1803Hjelle, Brian, 1796Hoa, Vu Quynh, 1605Hodge, Martin R., 1740Hogg, Nancy, 1489Holland, Jason W., 1475Holmdahl, Rikard, 1431Holterman, Lennart, 1721Holtick, Udo, 1595Holtzman, Michael J., 1438Hoogenboom, Hennie R., 2005Hooijberg, Erik, 2005Hufton, Simon E., 2005Huizinga, Tom W. J., 1506Hultqvist, Malin, 1431Hunninghake, Gary W., 1648Hutchings, Amanda, 1784

Isaacs, John D., 1595Ishikawa, Izumi, 1577Iwai, Shin-ichi, 1449Iwamoto, Sanju, 1449Iwanami, Norimasa, 1605

Jack, Hans-Martin, 1659Jacobs, Heinz, 1784Jain, Manu, 1834Jama, Fatimina M., 1884Janot, Laure, 1872Johansson, Sara M., 1969Johansson, Ulrika, 1711Johnson, Victor J., 1864Jorgensen, Christian, 1506

Kammertoens, Thomas, 1568Kang, Elizabeth M., 1693Kaynor, Campbell, 1960Kekalainen, Eliisa, 1988Keller, Evan T., 1423

Keller, Walter, 1730Keskin, Derin B., 1681Kim, Theo D., 1669Kin, Nicholas W., 1516Kitchens, Robert, 1438Kiyono, Hiroshi, 1577Kochman, Adam A., 1669Kojima, Yoshitsugu, 1760Kolbeck, Roland, 1740Kong, Tianqing, 1934Kopec, Jolanta, 1730Koup, Richard A., 1721Kryczek, Ilona, 1423Kuczkowski, Elizabeth, 2013Kueter, Esther W. M., 2005Kumar, Manoj, 1681Kung, James, 1872Kunisawa, Jun, 1577Kurahashi, Chika, 1449Kurashima, Yosuke, 1577Kurie, Jonathan M., 1926Kurotaki, Takehiro, 1803Kutomi, Goro, 1803

Lacouture, Sonia, 1842Lahesmaa, Riitta, 1969Lappas, Courtney M., 1693Laughlin, Mary, 2013Leclerc, Claude, 1825Lee, Jae Woo, 1855Lee, Youjin, 1960Lefrancois, Leo, 1524Li, Bing, 1568Li, Jie, 1605Li, Zhiguang, 1568Lilly, Craig M., 1901Lindenberg, Jelle J., 2005Lipsky, Peter E., 1634Liu, Chen, 1669Liu, Shubai, 1568Liu, Xiaojuan, 1960Lora, Jose M., 1740Lore, Karin, 1721Louis-Plence, Pascale, 1506Lozupone, Catherine, 1979Lu, Lu, 1814Lu, Sydney, 1669Lucas, David A., 1497Luster, Andrew D., 1901Luster, Michael I., 1864

Maciejewski, Jaroslaw P., 2013Mack, Doug G., 1979Maggıni, Julian, 1950Mahdi, Olaimatu S., 1814Majlessi, Laleh, 1825Makela, Satu, 1988Mannie, Mark D., 1458Mariani, Roberto, 1559Marquez, Gabriel, 1740Martin, Maureen P., 1625Martınez, Diego, 1950Martinez-A, Carlos, 1740Masunaga, Atsuko, 1449Mather, Thomas N., 1497Matthay, Michael A., 1855McIver, Zachariah, 2013McVicar, Daniel W., 1625Meditz, Amie, 1979Medoff, Benjamin D., 1901Mehal, Wajahat Z., 1884Metcalf, Julia A., 1625Mihalyo, Marianne A., 1524Miller, Jim, 1616Miller, J. Ross, 1784Miyairi, Isao, 1814Miyazaki, Akira, 1449Monick, Martha M., 1648

Morgan, Doris A., 1415Morgan, Geoffrey, 1784Moser, Jennifer M., 1693Murphy, George F., 1669Mustonen, Jukka, 1988Mutlu, Gokhan M., 1834

Nahmod, Karen, 1950Naoe, Michio, 1449Narvaez, Yadira, 2013Nathan, Neera R., 1751Naumann, Nora, 1693Neve, Etienne P. A., 1969Newton, Dianne, 1996Nguyen, Chau, 1768Nguyen, Duc-Hanh T., 1872Nitcheu-Tefit, Josianne, 1532Norman, Mikael, 1969Nouze, Clemence, 1825Nunez, Gabriel, 1913

O’Brien, Christopher, 1872Ogawa, Yoshio, 1449Oguchi, Katsuji, 1449O’Keefe, Christine L., 2013Olkhanud, Purevdorj, 1996Oppenheim, Joost J., 1413Osborn, Stephanie L., 1681Oura, Jun, 1803

Pajerowski, Anthony G., 1768Palmer, Brent E., 1979Parker, Ian, 1586Pascal, Veronique, 1625, 1751Pascall, John C., 1784Patel, Neel, 1669Penna, Giuseppe, 1559Perchonock, Claire E., 1768Percopo, Caroline M., 1693Phillips, Rebecca A., 1776Picarella, Dominic, 1740Pieters, Jean, 1825Plante, Marie-Michele, 1842Popov, Boris, 1855Powers, Linda S., 1648Pradera, Felicia, 1568Precopio, Melissa L., 1721Prescott, Joseph B., 1796

Qazi, Khaleda Rahman, 1969Qin, Zhihai, 1568Qiu, Yubin, 1740Qu, Yan, 1913Qui, Harry Z., 1524

Rae, Michelle, 1595Rahman, Meher K., 1893Ramirez-Jimenez, Francisco, 1532Ramirez-Montagut, Teresa, 1669Ramos, Madeleine S., 1438Rebrovich, Michelle, 1659Reinherz, Ellis L., 1681Reurs, Anneke W., 2005Reynolds, Jeff S., 1864Ribeiro, Jose M. C., 1497Richardson, Diana, 1864Rivest, Serge, 1842Rodriguez, Alexander, 2013Rohlfing, Michelle M., 1438Romieu-Mourez, Raphaelle, 1549Rose, Lorne A., 1814Rosenberg, Helene F., 1693Ruscetti, Francis W., 1415Ryffel, Bernhard, 1872

Sabatte, Juan, 1950Safrina, Olga, 1586Sahara, Hiroeki, 1803

Salamone, Gabriela, 1950Sanders, Virginia M., 1516Santamaria, Pere, 1884Santegoets, Saskia J. A. M., 2005Sa-Nunes, Anderson, 1497Sato, Noriyuki, 1803Scheper, Rik J., 2005Scheynius, Annika, 1969Schnell, Silke, 1784Schreiber, Hans, 1960Schreurs, Marco W. J., 2005Scully, Melanie, 1934Secher, Thomas, 1872Secombes, Christopher J., 1475Segura, Elodie, 1489Segura, Mariela, 1842Serikov, Vladimir, 1855Sethi, Gautam, 1926Shameli, Afshin, 1884Shapiro, Michael J., 1768Shapiro, Virginia Smith, 1768Shelley, C. Simon, 1934Shi, Yan, 1884Shimizu, Miki, 1577Siebenlist, Ulrich, 1751Siegel, Steven J., 1693Sims, Gary P., 1634Sindhi, Hamad, 1669Slaiby, Aaron M., 1524Smed-Sorensen, Anna, 1711Smith, Odette M., 1669So, Takanori, 1427Sobecks, Ronald M., 2013Somers, Veerle A., 2005Sperr, Wolfgang R., 1730Spetz, Anna-Lena, 1711Stagg, John, 1549Stauss, Hans J., 1532Steed, Paul M., 1872Stephens, Leslie A., 1884Stepkowski, Stanislaw M., 1542Su, Xiao, 1855Suh, David, 1669Sumitomo, Kenya, 1996Sunakawa, Hajime, 1803Svingen, Phyllis A., 1893Swartz, Jonathan M., 1693Szeliga, Wojciech, 1423Szymkowski, David E., 1872

Takahama, Yousuke, 1605Takahashi, Munehisa, 1942Takayama, Naoko, 1577Takeshita, Kumiko, 1449Tamura, Yasuaki, 1803Tan, Rusung, 1466Terwey, Theis H., 1669Thalhamer, Josef, 1730Thery, Clotilde, 1489Thomas, Seddon Y., 1901Tifrea, Delia, 1648Ting-De Ravin, SukSee, 1693Toes, Rene E. M., 1506Tone, Masahide, 1760Tone, Yukiko, 1760Torigoe, Toshihiko, 1803Touma, Maki, 1681Trevani, Analıa, 1950Tsujiyama, Kazuko, 1449Tuthill, Ralph, 2013Tuuminen, Tamara, 1988Tykocinski, Mark L., 1760

Ueda, Gosei, 1803Urich, Daniela, 1834

Vaheri, Antti, 1988Valent, Peter, 1730

2024 AUTHOR INDEX

Valenta, Rudolf, 1730van den Brink, Marcel R. M., 1669van den Eertwegh, Alfons J. M., 2005van der Voort, Ellen I. H., 1506van Duivenvoorde, Leonie M., 1506Varga, Steven M., 1648Vassaux, Georges, 1532Vatan, Linhua, 1423Veenstra, Timothy D., 1497Verdino, Petra, 1730Vermeulen, Monica, 1950Villeval, Jean-Luc, 1740von Euw, Erika, 1950Vrtala, Susanne, 1730

Wabl, Matthias, 1659Walker, Wendy E., 1700

Walther-Jallow, Lilian, 1711Wang, Helena L., 1834Wang, Howard D., 1438Wang, Tiehui, 1475Wang, Wei, 1864Wang, Xiao-Nong, 1595Wang, Xinzhong, 1960Wang, Yang, 1960Wei, Shuang, 1423Wei, Sindy H., 1586Williams, Robert W., 1814Wilson, Cara C., 1979Wong, Jamie, 1659

Xia, Dianren, 1926Xiong, Yuning, 1893Xu, Man, 1532

Yamada, Eriko, 1625Yarovinsky, Timur O., 1648Yashiro-Ohtani, Yumi, 1760Ye, Chunyan, 1796Yoshimura, Teizo, 1942You, Zhaoyang, 1960Yu, Ping, 1960Yu, Ying, 1586Yucesoy, Berran, 1864

Zalevsky, Jonathan, 1872Zammit, David J., 1524Zhang, Li, 1542Zou, Jun, 1475Zou, Weiping, 1423

2025AUTHOR INDEX

THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS 9650 ROCKVILLE PIKE ● BETHESDA, MD 20814-3994

TEL: (301) 634-7195 ● FAX: (301) 634-7733 FEDERAL TAX ID NO: 52-2317193 E-mail Address: members@aai.org ● Website Address: http://www.aai.org QUALIFICATIONS AND APPLICATION FOR REGULAR MEMBERSHIP 2007 MEMBERSHIP YEAR

The American Association of Immunologists (AAI) is a professional organization whose members have a strong interest in, and have made substantial contributions to, the science of immunology. AAI is a member of the Federation of American Societies for Experimental Biology (FASEB) and is responsible for the publication of The Journal of Immunology. To be eligible for election to membership in the AAI, a candidate must meet one of the following criteria: 1. Possess a Ph.D., (or equivalent graduate degree, e.g., D.Sc.) in immunology or related disciplines, or an M.D. (or equivalent medical degree, e.g., D.D.S.) and be the first author of one significant original publication on an immunological topic in a reputable, English language refereed journal. Manuscripts "in press" are acceptable when accompanied by a letter from the publisher or Editor-In-Chief of the journal affirming its acceptance and imminent publication. Abstracts and unpublished papers will not be considered in evaluating whether a candidate meets the publications requirement for membership. *

2. Be an established scientist with substantial achievement in a related discipline and have at least one collaborative paper on an immunological topic in a reputable, English language refereed journal.

* These requirements may be waived under exceptional circumstances if a candidate shows evidence of other appropriate training and/or substantial research accomplishment.

THIS APPLICATION PACKAGE MUST INCLUDE: 1. A current copy of your curriculum vitae including bibliography. 2. A copy of the title page of a first author publication that meets the criteria. 3. The name and signature of an active AAI member as your reference. NAME: _____________________________________________________________________________________________ DEGREE (YEAR) & INSTITUTION: _____________________________________________________________________ PUBLICATION: ______________________________________________________________________________________ CURRENT TITLE/ POSITION: __________________________________________________________________________ ADDRESS: __________________________________________________________________________________________ STREET: ____________________________________________________________________________________________ CITY: STATE: ZIP CODE: COUNTRY: _______________________ E-MAIL ADDRESS: ___________________________________________________________________________________ PHONE NO: _____________________________________________ FAX NO: ___________________________________ RESEARCH SPECIALTY: REFERENCE: NAME OF AAI MEMBER (please print clearly): ____________________________________________________________ SIGNATURE OF AAI MEMBER: ________________________________________________________________________ Applications should be mailed to the AAI office and marked to the attention of the AAI Membership Department. Please DO NOT send payment with your application. You will be invoiced upon approval.

Application Review Deadlines:

Applications are to be received in the AAI office by the first day of each month. 2007 Dues Rates: January 1 - December 31: U.S. - $260.00 Canadian - $267.50 �( )GST incl. International - $260.00

2027

THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS

9650 ROCKVILLE PIKE BETHESDA, MD 20814-3994 TEL: (301) 634-7195 FAX: (301) 634-7733 FEDERAL TAX ID NO: 52-2317193 E-mail Address: members@aai.org Website Address: http://www.aai.org

2007 TRAINEE MEMBERSHIP APPLICATION FORM Name: E-mail Address: _______________________________________________ Address: ______________________________________________________________________________________________________________________ City: State: Zip Code: _________________ Phone Number: Fax Number: __________________________________________ Qualified applicants must complete the information below and return this form with the required payment. Trainee members will receive a subscription to The Journal of Immunology and the AAI Newsletter. Trainee members will also have the privilege of attending and participating (without vote) in the AAI Annual Business Meeting. In addition, they will receive all AAI announcements and correspondence. Checks are to be made payable to AAI. All checks must be in U.S. dollars drawn on a U.S. bank and International money orders are accepted. Individuals may remain Trainee members for a maximum of eight (8) years. Certification must be renewed annually.

SECTION 1 -- APPLICANT INFORMATION

� I am a Pre-doctoral Trainee -- I expect to receive the ___________ (advanced degree) in _____________ (mo/yr)

� I am a Post-doctoral Trainee -- I hold the following advanced degree(s) (please indicate all advanced degrees held

and the month and year conferred): _______________________________________________________

SECTION 2 -- CERTIFICATION OF APPLICANT'S TRAINEE STATUS (to be completed by current AAI member)

As a current member of the AAI, I hereby certify that the applicant identified above is either a regularly matriculated pre-doctoral student or a post-doctoral trainee and, as such, is eligible to remain a Trainee Member of the AAI.

Current AAI Member's Name (First, MI, Last): _______________________________________________________________

Signature: _____________________________________________________________________________________________

Title (Dean, Dept. Chair, or Professor in Charge): _____________________________________________________________

AAI Member Number: Date: ________________________________________

SECTION 3 -- APPLICANT PLEDGE AND PAYMENT

I , pledge that any print copies of The Journal of Immunology purchased by me at the special subscription rate to Trainee Members are for my personal use. They will not be placed in a library for general use, sold, or replace a subscription currently purchased by an institution. I also agree that my on-line access to The JI will not be shared with others.

JANUARY 1 - DECEMBER 31, 2007

U.S. Member Canadian Member International Member

� $64.00 � $65.86 (online subscription; GST incl.) � $64.00 (online subscription)

� CHECK ENCLOSED � VISA � MASTERCARD � AMERICAN EXPRESS

CARD NUMBER:___________________________________________________________________________ EXPIRATION DATE:________________

SIGNATURE:___________________________________________________________________________________________________________________

Please select: � Online � Print and Online � $165.86 (print, online, GST & airmail incl.) � $164.00 (print, online & airmail incl.)

2028

lysosome exocytosis as well as mature IL-1� release in theP2X7R-null BMDM.

P2X7R-induced exocytosis of secretory lysosomes is LPSdependent and requires protein synthesis, proteasome activity,and NF-�B signaling

Given our previous finding (30) that LPS priming of BMDM wasrequired for efficient coupling of P2X7R to inflammasome activa-tion and IL-1� export, we tested whether a similar requirement forLPS priming characterized the activation of secretory lysosomeexocytosis by ATP. Notably, non-LPS-primed BMDM secretedonly a minimal amount of cathepsin B and no active caspase-1 inresponse to ATP stimulation (Fig. 3A). The coupling of P2X7R toinflammasome activation could be observed within 30 min of LPSpriming, as indicated by the ATP-stimulated accumulation of in-tracellular caspase-1 p10. Similarly, an increase in ATP-elicitedcathepsin B release was apparent within 30 min after initiationof LPS priming. In cells primed with LPS for longer durations(1 or 4 h), the ATP-stimulated release of both active caspase-1and cathepsin B was further increased in a coordinated manner.In the absence of ATP stimulation, even 4 h of LPS primingalone did not result in inflammasome activation, IL-1� secre-tion, or cathepsin B release. Furthermore, the ability of LPS topotentiate ATP-dependent caspase-1 activation and secretorylysosome exocytosis occurred before significant expression ofpro-IL-1� protein. These observations indicate that LPS prim-ing provides a necessary and common signal(s) for efficientcoupling of P2X7R to exocytosis of secretory lysosomes as wellas inflammasome activation.

Other experiments tested whether de novo protein synthesis ormaintained synthesis of rapid turnover proteins was necessary forP2X7R-dependent inflammasome activation and P2X7R-activatedlysosome exocytosis. Pretreatment of cells with the protein syn-thesis inhibitor cycloheximide, the proteasome inhibitor MG132,or the I�-B kinase inhibitor Bay 11-7085 before LPS priming com-pletely repressed not only intracellular pro-IL-1� accumulation,but the P2X7R-induced activation of the caspase-1 inflammasome.As indicated in Fig. 3, B and C, these three inhibitors similarlyrepressed the correlated lysosomal protein secretion, but did notchange the expression levels of procaspase-1 or cathepsin B. Theexpression of P2X7R and LAMP-1 protein, as well as P2X7Rchannel function, was not altered in cells treated with these phar-macological reagents (data not shown).

ASC, active caspase-1, and pannexin-1 (Px1) are required forIL-1� secretion, but not secretory lysosome exocytosisstimulated by P2X7R

The adaptor protein ASC, which is essential for assembly ofcaspase-1 inflammasome complexes, is also coreleased withcaspase-1 and IL-1� (10) (Fig. 8B). This suggests that the entireinflammasome complex is copackaged and released as a unit withits IL-1� product from ATP-stimulated cells. We used BMDMfrom ASC-null mice to test whether ASC was also required for theP2X7R-regulated exocytosis of secretory lysosomes, which coin-cided with IL-1� secretion. Fig. 4A shows that ASC�/� BMDMwere completely deficient in ATP-induced activation of inflam-masome complexes as well as the coupled release of matureIL-1� and active caspase-1. However, release of the soluble

FIGURE 2. Obligatory role of P2X7R in ATP-induced release of mature IL-1�, active caspase-1, cathepsin B, and LAMP-1. A, BMDM from P2X7R-null mice were primed with or without LPS (1 �g/ml) for 4 h, stimulated with 5 mM ATP, and processed for Western blot analysis of cell lysates orextracellular medium. These data are representative of results from five experiments. B, BMDM from P2X7R�/� or P2X7R�/� mice (both in C57BL/6background) were assayed for changes in cytosolic-free Ca2� in response to the indicated nucleotides. For analysis of P2X7R-mediated Ca influx, cells werefirst stimulated with a mixture of 30 �M each of ATP, ADP, and UDP to activate and desensitize P2Y receptors before P2X7R stimulation by 3 mM ATP.C and D, BMDM from P2X7R-null mice were primed with LPS (1 �g/ml) for 4 h, and then stimulated with 5 mM ATP or the indicated concentrationsof maitotoxin for 30 min. The extracellular medium was collected and assayed for IL-1� and cathepsin B release by Western blot (C) or IL-1� ELISA (D).C, “Lys” indicates whole cell lysates from unstimulated LPS-primed BMDM. Similar results were obtained in three experiments.

1916 NONCLASSICAL IL-1� EXPORT PATHWAYS IN MURINE MACROPHAGES

In our Department of Laboratory Medicine at Kantonsspital Aarau (570 beds, tertiary care center for a population of 600’000) the tenured position of a head for the Immunology Section is available per October 1, 2007.

Requirements:• Extensive Experience in Immunology testing

(Allergy, Autoimmunity, Plasma proteins)• Experience in clinical flowcytometry and stem cell processing• Strong interest in research projects• Support of clinicians in management of patients with immune

diseases

Send applications or further inquiries to:A.R. Huber, M.D., Professor and ChairmanDept. of Laboratory Medicine, Kantonspital Aarau AGCH-5001 Aarau, SwitzerlandPhone: +41 62 838 53 02Fax: +41 62 838 53 99

www.ksa.ch

UNIVERSITY OF SOUTHERN CALIFORNIAKeck School of Medicine

MELANOMA ONCOLOGIST

The USC/Norris Comprehensive Cancer Centerand the Department of Medicine of the KeckSchool of Medicine at the University ofSouthern California (USC) seek an outstandingphysician (M.D. or M.D./Ph.D.) to join theDivision of Cancer Medicine and BloodDiseases. We are seeking candidates with asuccessful track record in patient care andclinical/translational research in melanoma(especially with a focus on immunotherapy).The successful candidate will be nominated forthe Lucy and Berle Adams Chair andrecommended for appointment as Associate orFull Professor. We offer a highly competitivesalary package with excellent benefits,outstanding infrastructural research support andhigh quality laboratory space in the new175,000 sq ft Harlyne Norris Research Tower.

Melanoma diagnostics and therapeutics(including immunotherapy) have had aprominent history at USC. The patientpopulation at USC/Norris Cancer Hospital, USCUniversity Hospital and LAC�USC MedicalCenter is large, diverse and provides anoutstanding resource for clinical research,including clinical trials and translationalresearch. Significant growth in clinical,population-based, translational and basicscience research, in laboratory space resources,and in faculty and staff support will occur inthe next decade as a high priority of USC.

Qualifications: Candidates must be board-certified (or equivalent) in Internal Medicineand board eligible/certified in MedicalOncology. A strong background in patient careand clinical/translational research in melanoma(especially including immunotherapy) isessential, along with a track record of peer-reviewed clinical or laboratory funding.

Please send letter of interest and curriculumvitae to:

Search Committee—Lucy and Berle Adams ChairDivision of Cancer Medicine and Blood Diseases

USC/Norris Comprehensive Cancer CenterUniversity of Southern California

1441 Eastlake Ave., #3454Los Angeles, CA 90033

Attn: Dianne Moody(e-mail: dmoody@usc.edu)

The University of Southern California is an EOE/AA.

THE

OFJO

UR

NA

LIMMUNOLOGY

Need to Recruit?

Recruiting through The Journal of Immunology

money. Why pay more to reach geologists and physicists when you are seeking immunologists?

For further information, contact:Steve WestProfessional Media Group (PMG)

is the most economical way to reach the

steve@promedgroup.net

A quarter-page advertisement costs $815.

immunolog community without wastingy

856 795-5777-

Request For ProposalsPfi zer Is Seeking Research Partners

To Solve Some Of Its Key Translational Research Problems.

Do you share this research interest?• Want to learn more about Pfi zer’s specifi c goals in this area?

• Have an idea how to solve this problem?

• Have access to appropriate facilities, technologies and patients?

To learn more about this opportunity please visit

www.pfi zer.com/TranslationalMedicine

p

PROBLEM: IDENTIFICATION OF GENE EXPRESSION BIOMARKERS OF CLINICAL OUTCOMES IN RHEUMATOID ARTHRITIS

T MTR

AN

SLATIONAL M

ED

ICIN

E

BE

NCH TO PATIE

NT