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Author IndexAbbott, Derek J., 1458Adams, William C., 1721Adelsberger, Joseph W., 1625Adler, Adam J., 1524Admyre, Charlotte, 1969Adorini, Luciano, 1559Agapov, Eugene, 1438Aggarwal, Bharat B., 1926Ahmed, S. Ansar, 1776Ahn, Kwang Seok, 1926Akinci, I. Ozkan, 1834Ala-Houhala, Ilpo, 1988Albrecht, Imke, 1825Al-Garawi, Amal, 1740Almo, Steve, 1730Alpdogan, Onder, 1669Alter, Galit, 1625Altfeld, Marcus, 1625Amigorena, Sebastian, 1489, 1950Amuchastegui, Susana, 1559Andersen, John F., 1497Anderson, Stephen K., 1625, 1751Antonini, Valeria, 1681Apparailly, Florence, 1506Aquilano, Francesca, 1559Arstila, T. Petteri, 1988Arva Tatireddigari, Venkat R. R., 1814Auh, Sogyong, 1960
Baatar, Dolgor, 1996Backlund, Johan, 1431Bafica, Andre, 1497Baker, Christina M., 1834Bakker, Aleida M., 1506Ball, Tanja, 1730Banerji, Aleena, 1901Barrett, Christopher W., 1648Barrio, Marcela, 1950Baseler, Michael W., 1625Bauer, Kristin, 1431Bell, Michael P., 1893Belland, Robert J., 1814Bellmeyer, Amy, 1834Benoıt, Loralyn A., 1466Biragyn, Arya, 1996Bobenchik, April M., 1681Boivin, Marie-Noelle, 1549Bolwell, Brian, 2013Bondu-Hawkins, Virginie S., 1796Borsotti, Chiara, 1669Boyce, Joshua A., 1740Brady, Maya, 1760Brandwijk, Ricardo J., 2005Budinger, G. R. Scott, 1834Bushnell, Timothy, 1616Butcher, Geoffrey W., 1784Byrne, Gerald I., 1814
Cahalan, Michael D., 1586Carrington, Allison, 1475Carrington, Mary, 1625Carter, Christine, 1784Cascalho, Marilia, 1659Castilow, Elaine M., 1648Ceballos, Ana, 1950Cembrola, Katherine M., 1884Chandel, Navdeep S., 1834Charbonnier, Louis-Marie, 1506Chen, Sheng, 1634Chen, Shunle, 1634Chen, Wenhao, 1542Chen, Xiao Xiang, 1634
Chow, Andrew, 1669Claudio, Estefania, 1751Clayton, Linda K., 1681Coadwell, W. John, 1784Colgan, Sean P., 1934Collin, Matthew P., 1595Combaluzier, Benoit, 1825Conchon, Sophie, 1532Connick, Elizabeth, 1979Connolly, John E., 1681Conrads, Thomas P., 1497Cossetti, Chiara, 1559Cote-Sierra, Javier, 1740Coyle, Anthony J., 1740Critchley-Thorne, Rebecca J., 1532Croft, Michael, 1427Czapiga, Meggan, 1693
Dai, Ming-Shen, 1532Dai, Rujuan, 1776Davis, Randall, 2013De Carli, Elena, 1559de Gruijl, Tanja D., 2005Desrosiers, Melanie D., 1884Diao, Jun, 1542Dickinson, Anne M., 1595Dillon, Stephanie, 1979Dion, Carine, 1784Doberstein, Stephen K., 1872Domınguez-Punaro, Marıa C., 1842D’Souza, Michelle, 1979Dubyak, George R., 1913Dyer, Kimberly D., 1693
Eivazi, Araz, 1872Ennis, Francis A., 1988Erard, Francois, 1872Escara-Wilke, June, 1423Ezhevsky, Sergei A., 1872
Fakir, Michael J., 1884Faubion, William A., Jr., 1893Fedorov, Alexander A., 1730Ferry, Nicolas, 1532Fibbi, Benedetta, 1559Filen, Jan-Jonas, 1969Fluharty, Kara, 1864Focke, Margarete, 1730Fontenot, Andrew P., 1979Foster, Barbara, 1693Foster, Paul S., 1693Franchi, Luigi, 1913Francischetti, Ivo M. B., 1497Francois, Moıra, 1549Fraser, Christopher C., 1740Fu, Yang-Xin, 1960Furutani-Seiki, Makoto, 1605Furuuchi, Keiji, 1760
Gabrielsson, Susanne, 1969Gajewski, Thomas F., 1960Galipeau, Jacques, 1549Gallo, Robert C., 1415Garcia, Jessica E., 1825Garrod, Kym R., 1586Geffner, Jorge, 1950Gelderman, Kyra A., 1431Geraldes, Pedro, 1659Giarratana, Nadia, 1559Giordano, Mirta, 1950Gohda, Masashi, 1577Goldstein, Daniel R., 1700
Gondek, Lukasz, 2013Gonzalo, Jose-Angel, 1740Gottschalk, Marcelo, 1842Goudsmit, Jaap, 1721Gould, Aaron, 1438Goya, Inigo, 1740Graf, Beth, 1616Graham, Margaret, 1784Grayson, Mitchell H., 1438Groskreutz, Dayna, 1648Grubin, Jeremy, 1669Grusby, Michael J., 1681Gu, Yue Ying, 1634Guerin, Coralie, 1489Gupta, Naveen, 1855Gutierrez-Ramos, Jose-Carlos, 1740
Hagymasi, Adam T., 1524Hall, Pamela R., 1796Hamid, Qutayba, 1740Han, Wanda G. H., 1506Haniffa, Muzlifah A., 1595Hartl, Arnulf, 1730Hassan, Ihab, 1648Havenga, Menzo J. E., 1721Hedman, Klaus, 1988Heller, Glenn, 1669Hepburn, Lucy, 1784Herrmann, Kai, 1659Higuchi, Morio, 1577Hilkens, Catharien M. U., 1595Hirata, Koichi, 1803Hiratsuka, Hiroyoshi, 1803Hirohashi, Yoshihiko, 1803Hjelle, Brian, 1796Hoa, Vu Quynh, 1605Hodge, Martin R., 1740Hogg, Nancy, 1489Holland, Jason W., 1475Holmdahl, Rikard, 1431Holterman, Lennart, 1721Holtick, Udo, 1595Holtzman, Michael J., 1438Hoogenboom, Hennie R., 2005Hooijberg, Erik, 2005Hufton, Simon E., 2005Huizinga, Tom W. J., 1506Hultqvist, Malin, 1431Hunninghake, Gary W., 1648Hutchings, Amanda, 1784
Isaacs, John D., 1595Ishikawa, Izumi, 1577Iwai, Shin-ichi, 1449Iwamoto, Sanju, 1449Iwanami, Norimasa, 1605
Jack, Hans-Martin, 1659Jacobs, Heinz, 1784Jain, Manu, 1834Jama, Fatimina M., 1884Janot, Laure, 1872Johansson, Sara M., 1969Johansson, Ulrika, 1711Johnson, Victor J., 1864Jorgensen, Christian, 1506
Kammertoens, Thomas, 1568Kang, Elizabeth M., 1693Kaynor, Campbell, 1960Kekalainen, Eliisa, 1988Keller, Evan T., 1423
Keller, Walter, 1730Keskin, Derin B., 1681Kim, Theo D., 1669Kin, Nicholas W., 1516Kitchens, Robert, 1438Kiyono, Hiroshi, 1577Kochman, Adam A., 1669Kojima, Yoshitsugu, 1760Kolbeck, Roland, 1740Kong, Tianqing, 1934Kopec, Jolanta, 1730Koup, Richard A., 1721Kryczek, Ilona, 1423Kuczkowski, Elizabeth, 2013Kueter, Esther W. M., 2005Kumar, Manoj, 1681Kung, James, 1872Kunisawa, Jun, 1577Kurahashi, Chika, 1449Kurashima, Yosuke, 1577Kurie, Jonathan M., 1926Kurotaki, Takehiro, 1803Kutomi, Goro, 1803
Lacouture, Sonia, 1842Lahesmaa, Riitta, 1969Lappas, Courtney M., 1693Laughlin, Mary, 2013Leclerc, Claude, 1825Lee, Jae Woo, 1855Lee, Youjin, 1960Lefrancois, Leo, 1524Li, Bing, 1568Li, Jie, 1605Li, Zhiguang, 1568Lilly, Craig M., 1901Lindenberg, Jelle J., 2005Lipsky, Peter E., 1634Liu, Chen, 1669Liu, Shubai, 1568Liu, Xiaojuan, 1960Lora, Jose M., 1740Lore, Karin, 1721Louis-Plence, Pascale, 1506Lozupone, Catherine, 1979Lu, Lu, 1814Lu, Sydney, 1669Lucas, David A., 1497Luster, Andrew D., 1901Luster, Michael I., 1864
Maciejewski, Jaroslaw P., 2013Mack, Doug G., 1979Maggıni, Julian, 1950Mahdi, Olaimatu S., 1814Majlessi, Laleh, 1825Makela, Satu, 1988Mannie, Mark D., 1458Mariani, Roberto, 1559Marquez, Gabriel, 1740Martin, Maureen P., 1625Martınez, Diego, 1950Martinez-A, Carlos, 1740Masunaga, Atsuko, 1449Mather, Thomas N., 1497Matthay, Michael A., 1855McIver, Zachariah, 2013McVicar, Daniel W., 1625Meditz, Amie, 1979Medoff, Benjamin D., 1901Mehal, Wajahat Z., 1884Metcalf, Julia A., 1625Mihalyo, Marianne A., 1524Miller, Jim, 1616Miller, J. Ross, 1784Miyairi, Isao, 1814Miyazaki, Akira, 1449Monick, Martha M., 1648
Morgan, Doris A., 1415Morgan, Geoffrey, 1784Moser, Jennifer M., 1693Murphy, George F., 1669Mustonen, Jukka, 1988Mutlu, Gokhan M., 1834
Nahmod, Karen, 1950Naoe, Michio, 1449Narvaez, Yadira, 2013Nathan, Neera R., 1751Naumann, Nora, 1693Neve, Etienne P. A., 1969Newton, Dianne, 1996Nguyen, Chau, 1768Nguyen, Duc-Hanh T., 1872Nitcheu-Tefit, Josianne, 1532Norman, Mikael, 1969Nouze, Clemence, 1825Nunez, Gabriel, 1913
O’Brien, Christopher, 1872Ogawa, Yoshio, 1449Oguchi, Katsuji, 1449O’Keefe, Christine L., 2013Olkhanud, Purevdorj, 1996Oppenheim, Joost J., 1413Osborn, Stephanie L., 1681Oura, Jun, 1803
Pajerowski, Anthony G., 1768Palmer, Brent E., 1979Parker, Ian, 1586Pascal, Veronique, 1625, 1751Pascall, John C., 1784Patel, Neel, 1669Penna, Giuseppe, 1559Perchonock, Claire E., 1768Percopo, Caroline M., 1693Phillips, Rebecca A., 1776Picarella, Dominic, 1740Pieters, Jean, 1825Plante, Marie-Michele, 1842Popov, Boris, 1855Powers, Linda S., 1648Pradera, Felicia, 1568Precopio, Melissa L., 1721Prescott, Joseph B., 1796
Qazi, Khaleda Rahman, 1969Qin, Zhihai, 1568Qiu, Yubin, 1740Qu, Yan, 1913Qui, Harry Z., 1524
Rae, Michelle, 1595Rahman, Meher K., 1893Ramirez-Jimenez, Francisco, 1532Ramirez-Montagut, Teresa, 1669Ramos, Madeleine S., 1438Rebrovich, Michelle, 1659Reinherz, Ellis L., 1681Reurs, Anneke W., 2005Reynolds, Jeff S., 1864Ribeiro, Jose M. C., 1497Richardson, Diana, 1864Rivest, Serge, 1842Rodriguez, Alexander, 2013Rohlfing, Michelle M., 1438Romieu-Mourez, Raphaelle, 1549Rose, Lorne A., 1814Rosenberg, Helene F., 1693Ruscetti, Francis W., 1415Ryffel, Bernhard, 1872
Sabatte, Juan, 1950Safrina, Olga, 1586Sahara, Hiroeki, 1803
Salamone, Gabriela, 1950Sanders, Virginia M., 1516Santamaria, Pere, 1884Santegoets, Saskia J. A. M., 2005Sa-Nunes, Anderson, 1497Sato, Noriyuki, 1803Scheper, Rik J., 2005Scheynius, Annika, 1969Schnell, Silke, 1784Schreiber, Hans, 1960Schreurs, Marco W. J., 2005Scully, Melanie, 1934Secher, Thomas, 1872Secombes, Christopher J., 1475Segura, Elodie, 1489Segura, Mariela, 1842Serikov, Vladimir, 1855Sethi, Gautam, 1926Shameli, Afshin, 1884Shapiro, Michael J., 1768Shapiro, Virginia Smith, 1768Shelley, C. Simon, 1934Shi, Yan, 1884Shimizu, Miki, 1577Siebenlist, Ulrich, 1751Siegel, Steven J., 1693Sims, Gary P., 1634Sindhi, Hamad, 1669Slaiby, Aaron M., 1524Smed-Sorensen, Anna, 1711Smith, Odette M., 1669So, Takanori, 1427Sobecks, Ronald M., 2013Somers, Veerle A., 2005Sperr, Wolfgang R., 1730Spetz, Anna-Lena, 1711Stagg, John, 1549Stauss, Hans J., 1532Steed, Paul M., 1872Stephens, Leslie A., 1884Stepkowski, Stanislaw M., 1542Su, Xiao, 1855Suh, David, 1669Sumitomo, Kenya, 1996Sunakawa, Hajime, 1803Svingen, Phyllis A., 1893Swartz, Jonathan M., 1693Szeliga, Wojciech, 1423Szymkowski, David E., 1872
Takahama, Yousuke, 1605Takahashi, Munehisa, 1942Takayama, Naoko, 1577Takeshita, Kumiko, 1449Tamura, Yasuaki, 1803Tan, Rusung, 1466Terwey, Theis H., 1669Thalhamer, Josef, 1730Thery, Clotilde, 1489Thomas, Seddon Y., 1901Tifrea, Delia, 1648Ting-De Ravin, SukSee, 1693Toes, Rene E. M., 1506Tone, Masahide, 1760Tone, Yukiko, 1760Torigoe, Toshihiko, 1803Touma, Maki, 1681Trevani, Analıa, 1950Tsujiyama, Kazuko, 1449Tuthill, Ralph, 2013Tuuminen, Tamara, 1988Tykocinski, Mark L., 1760
Ueda, Gosei, 1803Urich, Daniela, 1834
Vaheri, Antti, 1988Valent, Peter, 1730
2024 AUTHOR INDEX
Valenta, Rudolf, 1730van den Brink, Marcel R. M., 1669van den Eertwegh, Alfons J. M., 2005van der Voort, Ellen I. H., 1506van Duivenvoorde, Leonie M., 1506Varga, Steven M., 1648Vassaux, Georges, 1532Vatan, Linhua, 1423Veenstra, Timothy D., 1497Verdino, Petra, 1730Vermeulen, Monica, 1950Villeval, Jean-Luc, 1740von Euw, Erika, 1950Vrtala, Susanne, 1730
Wabl, Matthias, 1659Walker, Wendy E., 1700
Walther-Jallow, Lilian, 1711Wang, Helena L., 1834Wang, Howard D., 1438Wang, Tiehui, 1475Wang, Wei, 1864Wang, Xiao-Nong, 1595Wang, Xinzhong, 1960Wang, Yang, 1960Wei, Shuang, 1423Wei, Sindy H., 1586Williams, Robert W., 1814Wilson, Cara C., 1979Wong, Jamie, 1659
Xia, Dianren, 1926Xiong, Yuning, 1893Xu, Man, 1532
Yamada, Eriko, 1625Yarovinsky, Timur O., 1648Yashiro-Ohtani, Yumi, 1760Ye, Chunyan, 1796Yoshimura, Teizo, 1942You, Zhaoyang, 1960Yu, Ping, 1960Yu, Ying, 1586Yucesoy, Berran, 1864
Zalevsky, Jonathan, 1872Zammit, David J., 1524Zhang, Li, 1542Zou, Jun, 1475Zou, Weiping, 1423
2025AUTHOR INDEX
THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS 9650 ROCKVILLE PIKE ● BETHESDA, MD 20814-3994
TEL: (301) 634-7195 ● FAX: (301) 634-7733 FEDERAL TAX ID NO: 52-2317193 E-mail Address: [email protected] ● Website Address: http://www.aai.org QUALIFICATIONS AND APPLICATION FOR REGULAR MEMBERSHIP 2007 MEMBERSHIP YEAR
The American Association of Immunologists (AAI) is a professional organization whose members have a strong interest in, and have made substantial contributions to, the science of immunology. AAI is a member of the Federation of American Societies for Experimental Biology (FASEB) and is responsible for the publication of The Journal of Immunology. To be eligible for election to membership in the AAI, a candidate must meet one of the following criteria: 1. Possess a Ph.D., (or equivalent graduate degree, e.g., D.Sc.) in immunology or related disciplines, or an M.D. (or equivalent medical degree, e.g., D.D.S.) and be the first author of one significant original publication on an immunological topic in a reputable, English language refereed journal. Manuscripts "in press" are acceptable when accompanied by a letter from the publisher or Editor-In-Chief of the journal affirming its acceptance and imminent publication. Abstracts and unpublished papers will not be considered in evaluating whether a candidate meets the publications requirement for membership. *
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2027
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2028
lysosome exocytosis as well as mature IL-1� release in theP2X7R-null BMDM.
P2X7R-induced exocytosis of secretory lysosomes is LPSdependent and requires protein synthesis, proteasome activity,and NF-�B signaling
Given our previous finding (30) that LPS priming of BMDM wasrequired for efficient coupling of P2X7R to inflammasome activa-tion and IL-1� export, we tested whether a similar requirement forLPS priming characterized the activation of secretory lysosomeexocytosis by ATP. Notably, non-LPS-primed BMDM secretedonly a minimal amount of cathepsin B and no active caspase-1 inresponse to ATP stimulation (Fig. 3A). The coupling of P2X7R toinflammasome activation could be observed within 30 min of LPSpriming, as indicated by the ATP-stimulated accumulation of in-tracellular caspase-1 p10. Similarly, an increase in ATP-elicitedcathepsin B release was apparent within 30 min after initiationof LPS priming. In cells primed with LPS for longer durations(1 or 4 h), the ATP-stimulated release of both active caspase-1and cathepsin B was further increased in a coordinated manner.In the absence of ATP stimulation, even 4 h of LPS primingalone did not result in inflammasome activation, IL-1� secre-tion, or cathepsin B release. Furthermore, the ability of LPS topotentiate ATP-dependent caspase-1 activation and secretorylysosome exocytosis occurred before significant expression ofpro-IL-1� protein. These observations indicate that LPS prim-ing provides a necessary and common signal(s) for efficientcoupling of P2X7R to exocytosis of secretory lysosomes as wellas inflammasome activation.
Other experiments tested whether de novo protein synthesis ormaintained synthesis of rapid turnover proteins was necessary forP2X7R-dependent inflammasome activation and P2X7R-activatedlysosome exocytosis. Pretreatment of cells with the protein syn-thesis inhibitor cycloheximide, the proteasome inhibitor MG132,or the I�-B kinase inhibitor Bay 11-7085 before LPS priming com-pletely repressed not only intracellular pro-IL-1� accumulation,but the P2X7R-induced activation of the caspase-1 inflammasome.As indicated in Fig. 3, B and C, these three inhibitors similarlyrepressed the correlated lysosomal protein secretion, but did notchange the expression levels of procaspase-1 or cathepsin B. Theexpression of P2X7R and LAMP-1 protein, as well as P2X7Rchannel function, was not altered in cells treated with these phar-macological reagents (data not shown).
ASC, active caspase-1, and pannexin-1 (Px1) are required forIL-1� secretion, but not secretory lysosome exocytosisstimulated by P2X7R
The adaptor protein ASC, which is essential for assembly ofcaspase-1 inflammasome complexes, is also coreleased withcaspase-1 and IL-1� (10) (Fig. 8B). This suggests that the entireinflammasome complex is copackaged and released as a unit withits IL-1� product from ATP-stimulated cells. We used BMDMfrom ASC-null mice to test whether ASC was also required for theP2X7R-regulated exocytosis of secretory lysosomes, which coin-cided with IL-1� secretion. Fig. 4A shows that ASC�/� BMDMwere completely deficient in ATP-induced activation of inflam-masome complexes as well as the coupled release of matureIL-1� and active caspase-1. However, release of the soluble
FIGURE 2. Obligatory role of P2X7R in ATP-induced release of mature IL-1�, active caspase-1, cathepsin B, and LAMP-1. A, BMDM from P2X7R-null mice were primed with or without LPS (1 �g/ml) for 4 h, stimulated with 5 mM ATP, and processed for Western blot analysis of cell lysates orextracellular medium. These data are representative of results from five experiments. B, BMDM from P2X7R�/� or P2X7R�/� mice (both in C57BL/6background) were assayed for changes in cytosolic-free Ca2� in response to the indicated nucleotides. For analysis of P2X7R-mediated Ca influx, cells werefirst stimulated with a mixture of 30 �M each of ATP, ADP, and UDP to activate and desensitize P2Y receptors before P2X7R stimulation by 3 mM ATP.C and D, BMDM from P2X7R-null mice were primed with LPS (1 �g/ml) for 4 h, and then stimulated with 5 mM ATP or the indicated concentrationsof maitotoxin for 30 min. The extracellular medium was collected and assayed for IL-1� and cathepsin B release by Western blot (C) or IL-1� ELISA (D).C, “Lys” indicates whole cell lysates from unstimulated LPS-primed BMDM. Similar results were obtained in three experiments.
1916 NONCLASSICAL IL-1� EXPORT PATHWAYS IN MURINE MACROPHAGES
In our Department of Laboratory Medicine at Kantonsspital Aarau (570 beds, tertiary care center for a population of 600’000) the tenured position of a head for the Immunology Section is available per October 1, 2007.
Requirements:• Extensive Experience in Immunology testing
(Allergy, Autoimmunity, Plasma proteins)• Experience in clinical flowcytometry and stem cell processing• Strong interest in research projects• Support of clinicians in management of patients with immune
diseases
Send applications or further inquiries to:A.R. Huber, M.D., Professor and ChairmanDept. of Laboratory Medicine, Kantonspital Aarau AGCH-5001 Aarau, SwitzerlandPhone: +41 62 838 53 02Fax: +41 62 838 53 99
www.ksa.ch
UNIVERSITY OF SOUTHERN CALIFORNIAKeck School of Medicine
MELANOMA ONCOLOGIST
The USC/Norris Comprehensive Cancer Centerand the Department of Medicine of the KeckSchool of Medicine at the University ofSouthern California (USC) seek an outstandingphysician (M.D. or M.D./Ph.D.) to join theDivision of Cancer Medicine and BloodDiseases. We are seeking candidates with asuccessful track record in patient care andclinical/translational research in melanoma(especially with a focus on immunotherapy).The successful candidate will be nominated forthe Lucy and Berle Adams Chair andrecommended for appointment as Associate orFull Professor. We offer a highly competitivesalary package with excellent benefits,outstanding infrastructural research support andhigh quality laboratory space in the new175,000 sq ft Harlyne Norris Research Tower.
Melanoma diagnostics and therapeutics(including immunotherapy) have had aprominent history at USC. The patientpopulation at USC/Norris Cancer Hospital, USCUniversity Hospital and LAC�USC MedicalCenter is large, diverse and provides anoutstanding resource for clinical research,including clinical trials and translationalresearch. Significant growth in clinical,population-based, translational and basicscience research, in laboratory space resources,and in faculty and staff support will occur inthe next decade as a high priority of USC.
Qualifications: Candidates must be board-certified (or equivalent) in Internal Medicineand board eligible/certified in MedicalOncology. A strong background in patient careand clinical/translational research in melanoma(especially including immunotherapy) isessential, along with a track record of peer-reviewed clinical or laboratory funding.
Please send letter of interest and curriculumvitae to:
Search Committee—Lucy and Berle Adams ChairDivision of Cancer Medicine and Blood Diseases
USC/Norris Comprehensive Cancer CenterUniversity of Southern California
1441 Eastlake Ave., #3454Los Angeles, CA 90033
Attn: Dianne Moody(e-mail: [email protected])
The University of Southern California is an EOE/AA.
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