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AC PARTY FACE POMEfficacious + Improve Appearance of Fine Lines & Wrinkles + Instant Lifting
Tomorrow’s Vision… Today!®
AC PARTY FACE POM
Technical Information:
Product Code: 20447
INCI Name: Water & Punica Granatum Extract & Citrus Aurantium Dulcis(Orange) Flower Extract
INCI Status: Conforms
Suggested Use Levels: 2.0 – 5.0%
Suggested Applications: Improves appearance of fine lines & wrinkles, lifting/ tightening of skin, anti-aging
Solubility: Water Soluble
The Natural Aging Process
• Over time, the rate of cellular proliferation decreases
• Metabolic functions slow down
• Signs of physical damage to the skin become more apparent
• Both intrinsic and extrinsic factors play a role in the aging process
AGING + THE PROCESS
Traditional methods used to lift & tighten the skin:
• Surgery• Application of Bovine Serum Albumin (BSA)• Chemical Peels
• Consumers want alternatives! Surgery is painful and time consuming and animal derived products have lost favor in the market
• Peptide technology is quite appealing amongst consumers
SKIN TIGHTENING + TYPICAL METHODS
Concept: Sweet Orange Peptides + Pomegranate Carbohydrates
• Sweet orange peptides have a low molecular weight (<400 daltons)• Pomegranate carbohydrates are cross-linked to form a biopolymer
network on the skin (>500,000 daltons)
• The low molecular weight of sweet orange peptides allows for maximum efficacy for deeply nurtured cells• Stimulate the proliferation of fibroblasts• Increase cellular propagation and metabolism
• The high molecular weight of pomegranate carbohydrates create a lifting effect while smoothing the skin to reduce the appearance of wrinkles
CONCEPTUALIZING AN ALTERNATIVE
Pomegranates + Sweet Oranges
• Both coincide with the continuously growing superfruittrend
• Superfruits are known for their high nutrient content, health benefits and for their superb commercial success
• Sales of pomegranate products have increased more than 400% in the last several years
MARKET TRENDS
Pomegranates + Sweet Oranges
• Both coincide with the continuously growing superfruittrend
• Superfruits are known for their high nutrient content, health benefits and for their superb commercial success
• Sales of pomegranate products have increased more than 400% in the last several years
MARKET TRENDS
AC PARTY FACE POMEFFICACY ASSAY RESULTS
in-vivo Skin Lifting Durability Assay
Protocol
• 13 m/f volunteers between the ages of 34 and 67 were given an O/W emulsion containing 4.0% AC Party Face Pom which was applied to the right thigh
• A cutometer (Courage-Khazakaelectronic GmbH – MPA 580) was used to measure changes in skin lifting properties
• Baseline measurements were taken and then readings after 1, 2, and 4 hours were recorded
8.5
17.2
4.5
0
2
4
6
8
10
12
14
16
18
20
1 Hour 2 Hours 4 Hours
Pe
rce
nt
(%)
Incr
eas
e
AC PARTY FACE POMEFFICACY ASSAY RESULTS
in-vivo Wrinkle Reduction Assay
Protocol
• 10 m/f volunteers between the ages 36 and 70 applied a topical containing 4.0% AC Party Face Pom to their outer eye area (crow’s feet) twice daily for 60 days
• Equipment: An optical profilometer(Nanovea PS50) with an image analyzer (Nanovea 3D Software)
• 1cm2 silicone polymer replicas were made at baseline, after 30 & 60 days
• The length, depth, quantity and surface area of the wrinkles in the replicas were measured using a speacializedcomputer program (QuantiridesSoftware from Monaderm)
29
12
17
20
39
15
22
29
0
5
10
15
20
25
30
35
40
45
Wrinkle Length Wrinkle Depth Number of Wrinkles Surface Area
Per
cen
t (%
) D
ecre
ase
30 Days 60 Days
AC PARTY FACE POMEFFICACY ASSAY RESULTS
in-vitro Collagen I Synthesis Assay
Protocol
• Human fibroblasts were inoculated at a concentration of approximately 6,000 cells per dish
• Cells were then removed and placed into an amino acid deficient medium and supplemented with AC Party Face Pom at levels of 1.0%, 2.0% and 4.0%
• Samples were compared to a control of amino acid deficient medium sans supplement
• Collagen I synthesis was determined by immunolabeling with primary and secondary antibodies
36
57
77
89
0
10
20
30
40
50
60
70
80
90
100
Control 1% AC PartyFace Pom
2% AC PartyFace Pom
4% AC PartyFace Pom
Pe
rce
nt
(%)
Incr
eas
e
AC PARTY FACE POMEFFICACY ASSAY RESULTS
in-vitro Fibroblast Revitalization Assay
Protocol
• Human fibroblasts were grown in a medium containing 1.0% and 2.0% AC Party Face Pom for 72 hours
• Cells were the subjected to UV stress
• One control was irradiated without being given any supplement; the other control was not irradiated
• Cellular revitalization was then measured 72 hours after UV exposure
1.25
0.29
0.48
0.67
0
0.2
0.4
0.6
0.8
1
1.2
1.4
Control (non-irradiated)
Control(irradiated)
1.0% AC PartyFace POM
2.0% AC PartyFace POM
Ab
sorb
ance
AC PARTY FACE POMEFFICACY ASSAY RESULTS
in-vivo Increase in Smoothness Assay
Protocol
• 15 volunteers between the ages of 36 – 65
• One forearm was treated with 4.0% AC Party Face Pom and the other forearm was used as the control
• Silicone polymer casts were made before and after product application
• The smoothing effect was observed with a profilometer equipped with an image analyzer
7.00%
13.00%
0.00%
2.00%
4.00%
6.00%
8.00%
10.00%
12.00%
14.00%
Control 4.0% AC Party Face POM
Pe
rce
nt
(%)
Incr
eas
e
AC PARTY FACE POMEFFICACY ASSAY RESULTS
in-vitro Increase in Cellular Proliferation
Protocol
• Human fibroblasts were inoculated at a concentration of approximately 6,000 cells per dish
• Cells were then removed and placed into an amino acid deficient medium and supplemented with AC Party Face Pom at levels of 1.0%, 2.0% and 4.0%
• Samples were compared to a control (an amino acid deficient medium without any supplement)
0.44
0.25
0.820.87
0.97
0
0.2
0.4
0.6
0.8
1
1.2
Control (w/FCS)
Control(depleted)
1.0% ACParty Face
POM
2.0% ACParty Face
POM
4.0% ACParty Face
POM
Ab
sorb
ance
AC PARTY FACE POM
Technical Information:
Product Code: 20447
INCI Name: Water & Punica Granatum Extract & Citrus Aurantium Dulcis(Orange) Flower Extract
INCI Status: Conforms
Suggested Use Levels: 2.0 – 5.0%
Suggested Applications: Improves appearance of fine lines & wrinkles, lifting/ tightening of skin, anti-aging
Solubility: Water Soluble
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