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8/18/2019 4.Plan of work
1/1
Plan Of Work
3. PLAN OF WORK
The present work was carried out to formulate controlled release matrix tablets of
VG. The controlled release matrix tablets were prepared by wet granulation method by
using various polymers. Keeping in view the objectives described above the following
plan of work was adopted.
THE SCHEME OF THE ENTIRE WORK IS LISTED AS FOLLOWS:
1. tandardi!ation of the method and construction of calibration curve for the
estimation of VG.
". #reformulation studies of drug and polymer by $T % &' spectral studies.
$ormulation of granules for VG controlled % release tablets by using polymersnamely (#)* K+ ,)- (#)* +1/ and Guar gum .
0. valuation of blend characteristics of granulated mixture of drug and polymers
2ngle of repose.
3etermination of bulk density.
3etermination of tapped density.
*ompressibility index.
3rug *ontent uniformity test etc.
,. *ompression of VG controlled % release tablets by using tablet punching machine.
/. valuation of physical parameters of VG controlled % release tablets
(ardness
$riability
4eight variation.
3rug *ontent uniformity test etc.
5. valuation of in vitro release characteristics of all formulations by using 6 #
dissolution apparatus " 7#addle8.
9. To study the mechanism of drug release by applying kinetic parameter
DEPT. OF PHARMACEUTICS PULLAREDDY INSTITUTE OF PHARMACY Page 23
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