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Plan Of Work

3. PLAN OF WORK

The present work was carried out to formulate controlled release matrix tablets of

VG. The controlled release matrix tablets were prepared by wet granulation method by

using various polymers. Keeping in view the objectives described above the following

plan of work was adopted.

THE SCHEME OF THE ENTIRE WORK IS LISTED AS FOLLOWS:

1. tandardi!ation of the method and construction of calibration curve for the

estimation of VG.

". #reformulation studies of drug and polymer by $T % &' spectral studies.

$ormulation of granules for VG controlled % release tablets by using polymersnamely (#)* K+ ,)- (#)* +1/ and Guar gum .

0. valuation of blend characteristics of granulated mixture of drug and polymers

2ngle of repose.

3etermination of bulk density.

3etermination of tapped density.

*ompressibility index.

3rug *ontent uniformity test etc.

,. *ompression of VG controlled % release tablets by using tablet punching machine.

/. valuation of physical parameters of VG controlled % release tablets

(ardness

$riability

4eight variation.

3rug *ontent uniformity test etc.

5. valuation of in vitro release characteristics of all formulations by using 6 #

dissolution apparatus " 7#addle8.

9. To study the mechanism of drug release by applying kinetic parameter

DEPT. OF PHARMACEUTICS PULLAREDDY INSTITUTE OF PHARMACY Page 23