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MacromolecMacromoleculesules
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Organic Organic CompoundsCompounds
• CompoundsCompounds that contain CARBONCARBON are called organicorganic.
• MacromoleculesMacromolecules are large organic moleculesorganic molecules.
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Carbon (C)Carbon (C)• CarbonCarbon has 4 electrons4 electrons in
outer shell.
• CarbonCarbon can form covalent covalent bondsbonds with as many as 4 4 other atoms (elements).
• Usually with C, H, O or NC, H, O or N.
• Example:Example: CHCH44(methane)(methane)
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Carbon is a Versatile Atom
• It has 4 electrons in an outer shell that holds eight
Carbon can share its electrons with other atoms to form up to four covalent bonds
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MacromoleculesMacromolecules
• Large organic molecules.Large organic molecules.• Also called POLYMERSPOLYMERS.• Made up of smaller “building
blocks” called MONOMERSMONOMERS.• Examples:Examples:
1. Carbohydrates1. Carbohydrates2. Lipids2. Lipids3. Proteins3. Proteins4. Nucleic acids (DNA and RNA)4. Nucleic acids (DNA and RNA)
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Question:Question:How Are How Are
MacromolecMacromolecules ules
Formed?Formed?
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Answer:Answer: Dehydration Dehydration SynthesisSynthesis
• Also called “condensation “condensation reaction”reaction”
• Forms polymerspolymers by combining monomersmonomers by “removing “removing water”water”.
HO H
HO HO HH
H2O
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Question:Question: How are How are
Macromolecules Macromolecules separated or separated or
digested?digested?
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Answer: Answer: HydrolysisHydrolysis
•Separates monomersmonomers by “adding water”“adding water”
HO HO HH
HO H
H2O
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CarbohydratCarbohydrateses
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CarbohydratesCarbohydrates
• Small sugar moleculesSmall sugar molecules to large sugar moleculeslarge sugar molecules.
• Examples:Examples:A.A. monosaccharidemonosaccharideB.B. disaccharidedisaccharideC.C. polysaccharidepolysaccharide
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Carbohydrates• Carbohydrates
include:• Small sugar
molecules in soft drinks
• Long starch molecules in pasta and potatoes
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CarbohydratesCarbohydratesMonosaccharide: one sugar Monosaccharide: one sugar
unitunit
Examples:Examples: glucose (glucose (C6H12O6)
deoxyribosedeoxyribose
riboseribose
FructoseFructose
GalactoseGalactose
glucoseglucose
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Monosaccharides:• Called simple sugars
Include glucose, fructose, & galactoseHave the same chemical, but different structural formulasC6H12O6
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Isomers• Glucose & fructose are isomers b/c their structures are different, but their chemical formulas are the same
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CarbohydratesCarbohydratesDisaccharide: two sugar unitDisaccharide: two sugar unit
Examples: Examples: – Sucrose (glucose+fructose)Sucrose (glucose+fructose)– Lactose (glucose+galactose)Lactose (glucose+galactose)– Maltose (glucose+glucose)Maltose (glucose+glucose)
glucoseglucoseglucoseglucose
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CarbohydratesCarbohydratesPolysaccharide: many sugar unitsPolysaccharide: many sugar units
Examples:Examples: starch (bread, starch (bread, potatoes)potatoes)
glycogen (beef glycogen (beef muscle)muscle)
cellulose (lettuce, cellulose (lettuce, corn)corn)
glucoseglucoseglucoseglucose
glucoseglucoseglucoseglucose
glucoseglucoseglucoseglucose
glucoseglucoseglucoseglucose
cellulosecellulose
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Sugars in Water• Simple sugars and double sugars
dissolve readily in water
They are hydrophilic, or “water-loving”
WATER MOLECULE
SUGAR MOLECULE
-OH groups make them water soluble
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ProteinsProteins
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Proteins Proteins (Polypeptides)(Polypeptides)
• Amino acids (20 different kinds of aa) bonded together by peptide bondspeptide bonds (polypeptidespolypeptides).
• Six functions of proteins:Six functions of proteins:1.1. Storage:Storage: albumin (egg white)albumin (egg white)2.2. Transport: Transport: hemoglobinhemoglobin3.3. Regulatory:Regulatory: hormoneshormones4.4. Movement:Movement: musclesmuscles5.5. Structural:Structural: membranes, hair, nailsmembranes, hair, nails6.6. Enzymes:Enzymes: cellular reactionscellular reactions
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20 Amino Acid Monomers
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Structure of Amino Acids
• Amino acids have a central carbon with 4 things boded to it:
Amino group –NH2
Carboxyl group -COOH
Hydrogen -H
Side group -R
Amino
group
Carboxylgroup
R group
Side groups
Leucine -hydrophobic
Serine-hydrophillic
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Linking Amino Acids• Cells link amino
acids together to make proteins
The process is called dehydration synthesisPeptide bonds form to hold the amino acids together
Carboxyl
Amino Side
Group
Dehydration Synthesis
Peptide Bond
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Proteins as Enzymes• Many proteins act as biological
catalysts or enzymes
Thousands of different enzymes exist in the body
Enzymes control the rate of chemical reactions by weakening bonds, thus lowering the amount of activation energy needed for the reaction
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Enzymes
Their folded conformation creates an area known as the active site.
Enzymes are globular proteins.
The nature and arrangement of amino acids in the active site make it specific for only one type of substrate.
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Enzyme + Substrate = Product
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How the Enzyme Works
Enzymes are reusable!!!Active site changes SHAPE
Called INDUCED FIT
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Denaturating ProteinsChanges in temperature & pH can
denature (unfold) a protein so it no longer works
Cooking denatures protein in eggs
Milk protein separates into curds & whey when it denatures
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LipidsLipids
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LipidsLipids• General term for compounds which are
not soluble in waternot soluble in water.• Remember:Remember: “stores the most energy”“stores the most energy”• Examples:Examples: 1. Fats1. Fats
2. Phospholipids2. Phospholipids3. Oils3. Oils4. Waxes4. Waxes5. Steroid hormones5. Steroid hormones6. Triglycerides6. Triglycerides
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Lipids• Lipids are hydrophobic –”water
fearing”
Includes fats, waxes, steroids, & oils
Do NOT mix with water
FAT MOLECULE
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LipidsLipidsSix functions of lipids:Six functions of lipids:
1.1. Long term Long term energy storageenergy storage2.2. Protection against heat loss Protection against heat loss (insulation)(insulation)3.3. Protection against physical shockProtection against physical shock4.4. Protection against water lossProtection against water loss5.5. Chemical messengers (hormones)Chemical messengers (hormones)6.6. Major component of membranes Major component of membranes (phospholipids)(phospholipids)
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Function of Lipids• Fats store energy, help to insulate the
body, and cushion and protect organs
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LipidsLipidsTriglycerides:Triglycerides:
ccomposed of 1 glycerol1 glycerol and 3 3 fatty acidsfatty acids.
H
H-C----O
H-C----O
H-C----O
H
glycerol
O
C-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH3
=
fatty acids
O
C-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH3
=
O
C-CH2-CH2-CH2-CH =CH-CH2 -CH
2 -CH2 -CH
2 -CH3
=
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Fatty AcidsFatty AcidsThere are two kinds of fatty acidsfatty acids you may see these on
food labels:
1.1. Saturated fatty acids:Saturated fatty acids: no double bonds (bad) no double bonds (bad)
2.2. Unsaturated fatty acids:Unsaturated fatty acids: double bonds (good) double bonds (good)O
C-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH2-CH3
=
saturatedsaturated
O
C-CH2-CH2-CH2-CH=CH-CH2 -CH
2 -CH2 -CH
2 -CH3
=
unsaturated
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Fats in Organisms• Most animal fats have a high
proportion of saturated fatty acids & exist as solids at room temperature (butter, margarine, shortening)
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Fats in Organisms• Most plant oils tend to be low in
saturated fatty acids & exist as liquids at room temperature (oils)
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Nucleic Nucleic AcidsAcids
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Nucleic acidsNucleic acids• Two types:Two types:
a. Deoxyribonucleic acid a. Deoxyribonucleic acid (DNA-(DNA- double helix) double helix) b. Ribonucleic acid (RNA-single b. Ribonucleic acid (RNA-single strand) strand)
• Nucleic acids Nucleic acids are composed of long chains of nucleotidesnucleotides linked by dehydration synthesisdehydration synthesis.
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Nucleic acidsNucleic acids• Nucleotides include:Nucleotides include:
phosphate groupphosphate grouppentose sugar (5-carbon)pentose sugar (5-carbon)nitrogenous bases:nitrogenous bases:
adenine (A)adenine (A)thymine (T) DNA onlythymine (T) DNA onlyuracil (U) RNA onlyuracil (U) RNA onlycytosine (C)cytosine (C)guanine (G)guanine (G)
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NucleotideNucleotide
OO=P-O O
PhosphatePhosphate GroupGroup
NNitrogenous baseNitrogenous base (A, G, C, or T)(A, G, C, or T)
CH2
O
C1C4
C3 C2
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SugarSugar(deoxyribose)(deoxyribose)
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DNA - double helixDNA - double helix
P
P
P
O
O
O
1
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4
5
5
3
3
5
P
P
PO
O
O
1
2 3
4
5
5
3
5
3
G C
T A
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CarbonCompounds
include
that consist of
which contain
that consist of that consist of that consist of
which contain which contain which contain
Section 2-3
Concept Map
Carbohydrates Lipids Nucleic acids Proteins
Sugars and starches
Fats and oils Nucleotides Amino Acids
Carbon,hydrogen,
oxygen
Carbon,hydrogen,
oxygen
Carbon,hydrogen,oxygen, nitrogen,
phosphorus
Carbon,hydrogen,oxygen,
nitrogen,
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