000 Introduction to immuno

7/27/2019 000 Introduction to immuno

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Molecular and Cellular Basis of MedicineMCBM III (Element 6)

Course code: MMCM 31105

(Taught by Unit of Microbiology (6ABC) andPathology (6D/7)

Faculty of Medicine, AIMST)

MCBM III/Element 6 CoordinatorDr. P. K. Rajesh. M.D. Microbiology

DDP, Faculty of Medicine, AIMST


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OVERVIEW of the ELEMENT

6A-Immunity =13 lectures 6B-Infection =25 lectures

6C-Control of Infectious disease =4 lectures

6D-Inflammation and repair =9 lectures 13 interactive review sessions

7 practical sessions of 3 hours each at the MDLs.

2 symposia (3 hours each)

YEAR I, TERM I and II


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Contact Hours:

Lectures 51 hours

Interactive review

sessions

13 hours

Practical + symposia 27 hours

Total 91 hours


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T/L Methodology

0

5

10

15

20

25

30

35

40

45

6A 6B 6C 6D

13

25

49

4

6

1

2

0

12

3

6

Practicals

IRS

Lectures


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Areas covered in this element:

(6A) The ways in which the immune system is involved inclearing infectious material and how the immune responsemay actually be damaging to the host (hypersensitivity andautoimmunity).

(6B) The biology of the groups of organisms that are capable

of causing disease in man (bacteria, viruses, protozoa,helminthes and fungi)

(6C) How organisms spread between individuals and howknowledge of the mechanisms is used to help prevent and treatinfectious disease in the host population

(6D) The pathological processes of inflammation, cell injury-its causes, mechanisms and the pathological aspects of woundhealing.


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Overall course Objectives:At the end of this course the student should be able to

explain the role of inflammation in activatingcomponents of the immune system.

describe the distinct components of the humoral and cell

mediated immune response

discuss the disorders of immune deficiency and

overactivity.

illustrate the structure and discuss the physiology of

microorganisms, involved in common infectiveprocesses.

compare and contrast between the modes of transmission

of microorganisms.


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Course Objectives continuedAt the end of this course the student should be able to

comprehend the principles underlying methods ofsterilization, disinfection and aseptic procedures.

explain the mechanisms of action of major antimicrobial

agents and the acquisition of resistance to antimicrobial

agents.

describe the pathological processes of inflammation, cell

injury and repair.

stain, observe and interpret a Gram smear. isolate bacterial colonies on pure culture.

Element 6 ABC Objectives and learning outcomes-B18.ppt

6D and Element 7 outcomes will be issued by Dr.Bharathi
http://localhost/var/www/apps/conversion/tmp/scratch_3/Element%206%20ABC%20Objectives%20and%20learning%20outcomes-B18.ppthttp://localhost/var/www/apps/conversion/tmp/scratch_3/Element%206%20ABC%20Objectives%20and%20learning%20outcomes-B18.ppthttp://localhost/var/www/apps/conversion/tmp/scratch_3/Element%206%20ABC%20Objectives%20and%20learning%20outcomes-B18.ppthttp://localhost/var/www/apps/conversion/tmp/scratch_3/Element%206%20ABC%20Objectives%20and%20learning%20outcomes-B18.ppt


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Important

Importance of Specific Learning Outcomes


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Components of SLO

The written description of

A task (ACTIVITY+CONTENT+CONDITION),

accompanied by

A criterion (quality, accuracy &/or speed)

denoting an acceptable level of proficiency,

which the learner should be able to do

at the end of a learning period which they couldnot do beforehand


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Elements of Learning Outcomes(Mager, 1975)

The Activity - The skill or behavior Whatthe learner will do(Action Verb)

The Content- what the learner will be able

to know, do, have an opinion about in relation tothe activity.

The criteria - the limits or range of anacceptable response, i.e., how well does thelearner have to perform?

Eg-..diagnose bone age from a given set of x-rays with an error of 1 year.


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SLO COMPONENTS

At the end of the training,the athlete should be able

to

RUN (ACTIVITY) 100 metres (CONTENT)

WITHIN 10 SECONDS

(CRITERIA)

USING HIS OWN LOWER

LIMBS (CONDITION)


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SLO COMPONENTSAt the end of this session the students willbe able tomeasureblood pressurecorrectly with an error of + or 5 mm on asupine resting patient/mannequin

Activity-Do what? Measure Content-Measure what? BP

Criteria-How well? Within +/ 5mm difference

Condition-Resources provided or deniedeg.Manual Sphygmomanometer/Mannequin


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Microbiology-Guinea worm-Medicine

Dr.P.K.Rajesh.M.D.


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Dr.P.K.Rajesh.M.D.

How do we get cold (flu)?


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Modes of transmission

DIRECT

Direct contact

Droplet transmission

Contact with soil

Inoculation skin/mucosa

Transplacental-mother

to child

INDIRECT

Vehicle borne-blood, milk

Vector borne-insects

Air borne (nuclei)

Fomite-objects

Unclean hands and

fingers

Assignment last date Sep 17

2012


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Dr.P.K.Rajesh.M.D.


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Dr.P.K.Rajesh.M.D.


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Total marks in MCBM III

Continuous Assessment Marks (30) +MCBM III Final Written Exam Marks (70)

= Total (maximum marks): 100


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Continuous Assessment

YEAR I, TERM I

FIRST CA (6A(1), D(1))

-THEORY (Objective/Subjective)

SECOND CA (6A(2),6D(2))


YEAR I, TERM II

THIRD CA (6B(1),7(1))


FOURTH CA (6B(2)C, 7 (2))


- PRACTICAL (Marks allotted to stand alone multi-disciplinary OSPE paper)


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ALL CAs Micro 60:Path 40

For eg CA 1-6A/6D (1)

6A-(10 MCQ=10 marks/4 SAQ=20 marks)=30 marks

6D-(10 MCQ=10 marks/2 SAQ=10 marks)=20 marks

For eg CA 3-6B/7 (1)

6B-(10 MCQ=10 marks/4 SAQ=20 marks)=30 marksE7-(10 MCQ=10 marks/2 SAQ=10 marks)=20 marks


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How is the continuous assessment (CA)

score (30 marks) in MCBM III derived?

Avg of the four CAs out of 30-

Reduced to 24

Assignments marks out of 6 is

then added


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Final Examination, Mod 2010(First Professional Examination)

MCBM III FinalExamination (written);

End of year 1

Total marks: 100

Elements 6 (A,B,C,D)

(Immunology, Infection,Control & Inflammation)*

(20+35+10+15)=80 marks

Element 7

(Neoplasia)*

20 marks

100 marks (60M:40P)is reduced to a maximum

of 70


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Types of questions used in the written test:

2010Objective (30% of total marks) Multiple choice questions (50* 1 mark)otal

marks)

Short answer questions (6 * 5 marks)

Long answer questions (2* 10 marks)


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Final exam, distribution, 2010-eg 1

MCQ (1 mark) SAQ (5 marks) LAQ (10 marks)

6A (20) 10 1 0.5

6B (35) 15 2 1

6C (10) 5 0.5

6D (15) 10 1

E7 (20) 10 2

Total

Number

50 6 2


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Final exam,distribution, 2010-eg 2

MCQ (1 mark) SAQ (5 marks) LAQ(10 marks)

6A (20) 10 2

6B (35) 15 2 1

6C (10) 5 1

6D (15) 10 1

E7 (20) 10 1

Total Number 50 6 2


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Dr.P.K.Rajesh.M.D.


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Dr.P.K.Rajesh.M.D.

Egs of Common fungi

Yeast-Cryptococcus neoformans

Yeast like-Candida albicans

Moulds- Dermatophytes Dimorphic fungi- Systemic fungi


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Dr.P.K.Rajesh.M.D.

Remember

NO MICRO-ORGANISM WANTS TO CAUSE

DISEASE

(They like to live in us because of our body

temperature-37C)

S l ti


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Sample question:Multiple-choice question

(choose the single best answer)

Which one of the following organism is non motile?

A. Escherichia coli

B. Helicobacter pyloriC. Salmonella typhi

D. Clostridium tetani

KEY: [ D ]


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Theory questions [10 marks]1 (i) Define Hypersensitivity [2 marks]

(ii) State the differences between immediate and delayed-type hypersensitivity reaction. [4 marks]

(iii) With examples, discuss the mechanism of Type III

hypersensitivity reaction [4 marks]


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Dr.P.K.Rajesh.M.D.

S l ti


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Poliovirus predominantly infects the human through

A. droplet nuclei

B. feaco oral routeC. vector transmission

D. transplacental route

KEY: [ B ]


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Poliomyelitis-viral infection

Dr.P.K.Rajesh.M.D.

S l ti


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Father of immunization is

A. Edward Jenner

B. Robert KochC. Louis Pasteur

D. Alexander Fleming

KEY: [ A ]


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Break-Small pox-eradication

Dr.P.K.Rajesh.M.D.

An e ample of an OSPE q estion


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An example of an OSPE question(held as part of a multidisciplinary practical

examination, end of year 1)

A. Name this method of

antibiotic susceptibility

testing. (1 mark)

Key-Disc diffusion/Kirby Bauer

B. Which antibiotic would ideally

be chosen?(1 mark)

Key-The one with the largest zoneof inhibition


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Periodic academic monitoring of students

Interactive review sessions (IRS) on topics that have

been recently covered (1 IRS:4 Lectures)

Students provided marking schemes after every CA

Slots scheduled in timetable to provide and receive

feedback regarding CA

Low achievers (less than 40pc) are called for

discussion with their CA papers

Symposia are used for all students to be oriented

with essential general concepts


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Practical session


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Emerging and re-emerging infections-2010

St d t t B15 2010


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Student posters-B15-2010


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International papers from symposium

EPIDEMICS2-The second International Conference

on infectious disease dynamics

Athens, Greece, 2-4 December 2009


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International papers from symposium

I International Conference on Antimicrobial

Research (ICAR2010), 3-5 November 2010,

Valladolid (Spain)

Bacteriophage therapy: reappraisal of a potential

answer for surgical site infections (abstract code:

773) has been accepted for VIRTUAL presentation

at ICAR2010 - I International Conference onAntimicrobial Research.


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Recommended books
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