Extra-mesenchymal Chondrosarcoma

References

Discussion

Background

A CASE OF MESENCHYMAL CHONDROSARCOMADepartment of Anatomical Pathology, University of Limpopo-MEDUNSA

CAMPUS

Objective Materials & Methods

Conclusion

1.Arch Pathol Lab Med—Vol 131, February 2007

2.Weis S, Goldblum J.  Cartilaginous Soft Tissue Tumors. In: Weis S, Goldblum J, editors.  Enzinger and Weis’s Soft Tissue Tumors, 4th Edition. 2001. p 1361-1388.

A 41 year female with a large left thigh mass.She also has a small mass on the back of the right shoulder which has a remarkable increase in contrast uptake on nuclear scan. She has a previous history of an excision of a thyroid mass done at a private institution and the biopsy result was that of a Chondrosarcoma..

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The gross, histological features and immunohistochemical profile of this tumour are those of a extraskeletal mesenchymal chondrosarcoma.

An incisional biopsy of the left thigh mass was performed and the result was a mesenchymal chondrosarcoma.

Then an excisional biopsy was done.

 Immunohistochemistry –

S100 - Positive

Vimentin - Positive;

Cytokeratin AE/13 - Negative. .

Microscopic findings –

The sections show a diffuse proliferation of pleomorphic small, round to oval cells.

In some areas, a haemangiopericytoma-like growth pattern is present.

Cartilagenious areas with mild pleomorphism of chondrocytes in the lacunae and calcifications are present.

H & E

SKOSANA KC, BIDA MN

Vimentin

S100

AE1/AE3

Results

IntroductionMesenchymal chondrosarcomas constitute less than 2 % of all chondrosarcomas. Approximately two thirds of cases of mesenchymal chondrosarcoma occur in bone while the rest occur in places outside of the bone—i.e.in extraskeletal locations.They are aggressive lesions with a high propensity for metastases.Mesenchymal chondrosarcoma is a fast growing tumor that spreads more often. They can remain dormant for long periods of time.

This case illustrates multi-focality, recurrence and metachronous nature of a extraskeletal mesenchymal chondrosarcoma.