View
2.277
Download
6
Category
Tags:
Preview:
DESCRIPTION
Pierre Guiot, Director Research and Development, Tevan B.V., The Netherlands
Citation preview
TBLI CONFERENCE ASIA 2008 BANGKOK, THAILAND
Tevan BV – the NetherlandsWebsite: www.tevan.com
CEO : M.L. GAETHOFSR&D : Dr. Ir. P. GUIOT
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
CHLORINE FREE TEVAN®SIL = HERLISIL®
AND CHLORINE AND METAL FREETEVAN® QA
TEVAN® PANOX TEVAN® PANOXO
1.PHYSICAL, CHEMICAL and
BIOLOGICAL ASPECTS
HYDROGEN PEROXIDE A NATURAL GERM KILLER
Cells involved into the immune system produce hydrogen peroxide
Hydrogen peroxide is thus a natural germ killer
Outside of the immune system hydrogen peroxide needs synergy
2.PREVIOUS SYNERGY
PEROXIDE, SILVER SALT
PREVIOUS SYNERGY WITH SILVER
Silver modifies proteins
Catalase is thus neutralized
Hydrogen peroxide can exert its full action
Silver adsorbs on the germ’s membrane and modifies the membrane potential
WHO recommendation =0.1 mg Ag / L water
Ag body retention rate =0-10%Calculus of Ag2S are
formed which are eliminated from the body
Nevertheless, silver is considered as a heavy metal and its future is questionable vs annex 1 of 98/8/EEC (Ag is already banned in E and P)
HERLISIL®Registered in B, NL, F, E, P, GB, D, CH, PL, Ma, Tun, Eg
NF T 72 18015 min.2%-Enterovirus polio-Orthopox virus-Human adenovirus
Virus
-60 min.10%-Naegleria fowleriAmoeba
NF T 72 23160 min.1%-Bacillus subtilis-Bacillus cereus-Clostridium sporogenes
NF T 72 23120 min.10%-Bacillus subtilis-Bacillus cereus-Clostridium sporogenes
Spores
EN 165015 min.15%-Aspergillus niger-Candida albicans
Fungi
NF T 301IMO
5 min.15 min.
0.05%0.25%
-Listeria monocytogenes-Escherichia coli
EN 13 62324 hours0.02%-Legionella pneumophila
EN 13 6235 min.2%-Legionella pneumophila
EN 12765 min.0.1%-Legionella pneumophila
EN 12765 min.14%-Pseudomonas areuginosa-Staphilococcus aureus-Escherichia coli-Enterococcus hirea
Bacteria
NormsTimesConcentrationsOrganismsSpecies
TEVAN®SILWELLS REHABILITATION
CLEANING with TEVAN® RAPID TWB (mix of organic and mineral acids, surfactants)
DECONTAMINATION with TEVAN® SIL @ 200 ppm, 24 hours.
RESULTSProblems due to E. coli and Pseudomonas presence are solved
TEVAN® SIL IN COOLING TOWER PIPES
‘EFFECT ON BIOFILM’
Tevan® Sil @ 100 ppm for 18 hours
and then @ 500 ppm for 1 additional hour within the glass made pipe’s flow
@ DSM, NL
TEVAN® SIL ON REVERSE OSMOSIS MEMBRANES @ VITENS, NL
A constant injection of TEVAN® SIL @ 3 ppm
prevents membrane clogging and enables a
constant water flow in the water installations
3.OTHER SYNERGIES
OTHER SYNERGIES
Quaternary ammoniumsAdsorption on membranes
PeracidsOxidizes SH, NH2, Open double bonds
Fatty oxo aminesActive wetting agents (innovative)
Essential oils (terpenic skeleton) Active fragrances (innovative)
3.1.TEVAN® QA’s
PEROXIDE, QUATERNARY AMMONIUM
TEVAN® QA 250
Derived from EN 16505 min.3%-Saccharomyces cerevisiae-Saccharomyces diastaticus
Yeasts
EN 12765 min.4%-Candida albicansFungi
NF T 72 30130 min.10%-Mycobacterium tuberculosis
Mycobacteria
Derived from EN 12765 min.3%-Lactobacillus brevis-Pediococcus damnosus
EN 12765 min.4%-Pseudomonas aeruginosa-Staphilococcus aureus-Escherichia coli-Enterococcus hirea
Bacteria
NormsTimesConcentrationsOrganismsSpecies
MULTI INDUCED EVAPORATIONTECHNOLOGY
Aerosolisation of TEVAN® QA 80 with CLIM O’ MEDIC enabled good results in laboratories and manufacturing places
TEVAN® QA 80@ Glaxo Smith Kline, Belgium
Treatment of clean rooms and SAS used for vaccines manufacturing in B, F, D, H, USA, CND
Aerosolisation @ 12 g / m3
Droplets of < 10 µm
A Δ Log reduction of 6 is required and obtained for very resistant germs
TEVAN® QA 80 ranked first among 25 products
TEVAN® QA 80@ Bayer Crop Science, Belgium
Aerosolisation Metatecta Cy. device = Clim’O Medic®
Rooms = from 50 to 150 m3
Droplets = 5-10 µm Time = 45 min. RT Dispersed amount = 10 g / m3
Δ Log > 7 even under tables and inside cabinets For:
– Bacteria = Gram-negative Agrobacterium
TEVAN® QA 80@ Virco (Johnson & Johnson), Belgium
Aerosolisation Metatecta Cy. device = Clim’O Medic®
Rooms = 60 m3
Droplets = 5-10 µm Time = 45 min. RT Dispersed amount = 10 g/m3
For : HIV’s DNA which is destroyed at 96 %
3.2.TEVAN® PANOX
PEROXIDE, PERACID, FATTY OXO AMINEINNOVATIVE: COMBINATION OF 3 ACTIVES
TEVAN® PANOXRegistered in F, GB, D, CH
PASTEUR INSTITUTE FRANCE, 2005/2006 test results
NF T 72 18015 min.2%-Enterovirus polio-Orthopox virus-Human adenovirus
Virus
AOAC(FDA approved in USA)Minntech lab.
Δlog5 5 min. Δlog6 10 min.Δlog7 20 min.
3%-Mycobacterium terraeMycobacteria
NF T 72 30130 min.5%-Bacillus subtilis-Bacillus cereus-Clostridium sporogenes
Spores
EN 165010 min.0.5%-Tricophyton mentagrophytes
EN 165015 min.2%-Aspergillus niger-Candida albicans
Fungi
EN 127610 min.0.1%-Salmonella typhi
EN 13 62324 hours0.02%-Legionella pneumophila
EN 13 6235 min.1%-Legionella pneumophila
EN 127624 hours0.02%-Legionella pneumophila
EN 127660 min.0.05%-Legionella pneumophila
EN 12765 min.0.1%-Pseudomonas aeruginosa-Staphilococcus aureus-Escherichia coli-Enterococcus hirea-Legionella pneumophila
Bacteria
NormsTimesConcentrationsOrganismsSpecies
TEVAN® PANOXStudy on biofilm at TNO, NL
Control A biofilm hosting Pseudomonas aeruginosa was formed on a
stainless steel coupon of 0.8 µm roughness A 5 min. water treatment was achieved The coupon was rinsed with 1 m3 water / m2 surface / hour The biofilm stayed on the coupon
Test A biofilm hosting Pseudomonas aeruginosa was formed on a
stainless steel coupon of 0.8 µm roughness A 5 min. treatment with TEVAN® PANOX 1% in water was
achieved The coupon was rinsed with 1 m3 water / m2 surface / hour The biofilm was removed from the coupon
TEVAN® PANOXStudy on biofilm at TNO, NL
Control After a 5 min. water treatment followed by a water rinsing
(1 m3 water / m2 surface / hour), the stainless steel coupon (0.8 µm roughness) was dyed with syto 9 and propidium
The Pseudomonas aeruginosa colonies are well apparent
Test After a 5 min. treatment with a 1% concentration of TEVAN®
PANOX followed by a water rinsing (1 m3 water / m2 surface / hour), the stainless steel coupon (0.8 µm roughness) was dyed with syto 9 and propidium
The Pseudomonas aeruginosa colonies are removed
TEVAN® PANOXNATURAL WATER EXTRACTION
@ Nestlé Waters Vittel, France
Strains tested and methods used are specific to Nestlé
Product was at 2% with 30 min. contact
A Δlog reduction of 5.5 is obtained for all strains
TEVAN® PANOX is the best product ever tested by Nestlé
TEVAN® PANOXSpore forming bacteria Clostridium perfringens
on working surfaces in slaughterhouses @ Wouters, NLFormulation @ 0.33% overnight
00>900Conditioned meat warehouse
000Carving place
000Slaughter place
After 5 weeks treatmentcfu/100 cm2
After 3 weeks treatmentcfu/100 cm2
After 1 week treatmentcfu/100 cm2
Location
MULTI INDUCED EVAPORATION TECHNOLOGY
Aerosolisation of TEVAN® PANOX with CLIM O’ MEDIC enabled good results in laboratories and hospital rooms
TEVAN® PANOXAerosolisation @ 33% @ Virco (Johnson & Johnson), Belgium
• Device = Clim’O Medic® (Metatecta Cy.)• Room = 60 m3
• RT• Droplets = 5-10 µm• Amount = 10 g/m3
• For : HIV’s DNA which is destroyed at 100%
TEVAN® PANOXAerosolisation @ 33%
@ Heilig Hart Hospital with the help of the University of Louvain B
Hospital room including bath room = 50 m3
Device = Clim’O Medic (Metatecta) in the bedroom itself
RT = 220C Time = 30 minutes Droplets = 5 – 10 µm Dispersion = 16 g / m3
Organisms = Staphylococcus aureus, Aspergillus niger, Geobacillus stearothermophilus
ΔLog 3 !ΔLog 3.5 !ΔLog >5
S aureusA nigerG stearo
Within the bathroom cabinet
ΔLog > 7ΔLog 3.5 !ΔLog >5
S aureusA nigerG stearo
Within the bedroom cabinet
ΔLog > 7ΔLog > 6ΔLog > 5
S aureusA nigerG stearo
Floor, walls, ceiling
TEVAN® PANOXDEFRA approved disinfectant since early 2007
DEFRA = UK DEPARTMENT of ENVIRONMENT, FOOD and RURAL AFFAIRS
1%SalmonellaGeneral
2%ParamyxovirusPoultry Newcastle
1%AphtovirusFoot & mouth
TEVAN® PANOX
OrganismDisease
3.3TEVAN® PANOXO
PEROXIDE, PERACID, FATTY OXO AMINE, ESSENTIAL OIL
INNOVATIVE: COMBINATION OF 4 ACTIVES
NF T 72 18030 min.60%-Enterovirus polio-Orthopox virus -Human adenovirus
Virus
NF T 72 30130 min.80%-Bacillus subtilis-Bacillus cereus-Clostridium sporogenes
Spores
EN 165010 min.40%-Tricophyton mentagrophytes
EN 165015 min.40%-Aspergillus niger-Candida albicans
Fungi
EN 127610 min.10%-Salmonella typhi
EN 12765 min.20%-Pseudomonas aeruginosa-Staphilococcus aureus-Escherichia coli-Enterococcus hirea
Bacteria
NormsTimesConcentrationsOrganismsSpecies
TEVAN® PANOXORTU for SURFACE TREATMENTS
PASTEUR INSTITUTE FRANCE, 2005/2006 test results
TEVAN® PANOXO GELInnovative RTU for vertical surface and ceiling treatments, test 1
id.30 min.Porcelainid.30 min.Aluminumid.30 min.Copper
id.30 min.Stainless steel
id.30 min.Galvanized steel
Doesn’t sag
30 min.Plastic PVC
ResultTimeSurface
TEVAN® PANOXO GEL @ CENTER PARK KEMPERVENNEN, NL
Innovative RTU FOR WALL AND CEILING CLEANING, test 2
Walls presenting black fungal marks Application of TEVAN® PANOXO GEL @ RT for 30 minutes Rinse off No mark anymore
TEVAN® PANOXORTU in agriculture (fungus fusarium oxysporum on tulip bulbs)
@ ACN, NLUltrasonic generator, droplets 1µm ,250C, RH 70%, 40 min.
1TEVAN® PANOXO
1.08Jet 5 1%
1.33Formaline 10%
4.83Formaline 1%
Treatments
14.33On rinsed and dried contaminated bulbs
25.33In contaminated water
0.5In original uncontaminated water
Average cfu’sAssays
4.COMPARISON, APPLICATIONS,
CONCLUSIONS, REFEREES
DISINFECTING AGENTS COMPARISON
Quats Phenolics Aldehydes Chlorine Hydrogen Stabilizedperoxide hydrogen
peroxideSpectrum Semi broad* Broad Broad Semi broad* Broad Broad
Contact time Short Long Long Short Long Short
Efficacy Semi good* Poor Good Semi good* Poor Good
Toxicity Moderate Moderate High Moderate Low Low
Residue Yes Yes Yes Yes No No
Corrosion Low Moderate Low High Low Low to Moderate**
Environment Poor Poor Poor Poor Good Good
Odour No Yes Yes Yes No Yes/No**
Biodegradation 70% 85% 90% 100% 100%in 20 days in 20 days in 20 days seconds seconds
Action on biofilm No No No No Yes*** Yes***
• * More and more germs are presenting resistance• ** Depending on the ingredients• *** H2O2 produces micro turbulences through the production of gaseous oxygen
• Source: Tevan BV compilation 2003
SYNERGISED HYDROGEN PEROXIDE APPLICATION FIELDS
WATER SYSTEMS Drinking waters (public, domestic, transport carriers) Industrial waters (cooling towers, air conditioning, sprinklers) Waste waters Still waters Sport & Recreation (swimming pools, fountains)
AGRICULTURE Transport materials Watering devices, irrigation, hydroponic cultures Seeds, bulbs Vegetables, fruits, flowers Greenhouses
LIVESTOCK Potable water distribution for animals Aquaculture
SURFACES and DEVICES Hospital theatres, medical tools, dentistry, clean rooms / broilers, hatcheries, stables, pigsties, etc. Metallurgy
FOOD and BEVERAGE Breweries, dairies, slaughterhouses, vintage barrels, soft drinks Baker’s & confectioner’s
SOME NUMBERS
From Kaiser http://www.hkc22.com/waterdisinfection.html Water world market in 2010 = 412 billion $
From Ecodis: Water disinfection = 7.95 billions $
From the biocides information services: Global biocides market = 84 billions $ In aquaculture = 9.42 billions $ For metallic surfaces = 9.15 billions $ In cooling towers = 87.3 millions $
From Herli-France 31 255 wells in France
From society statistics for nosocomial diseases: 1.71 billions $ spent in USA and still 20 000 deaths/Y
Nosocomial diseases in France: 800 000 infections and 10 000 deaths/Y
REFEREES Du Pont de Nemours, Belgium for Tevan® Sil in cooling towers water
Générale des Eaux, France for Tevan® Sil in drinking water distribution systems
Veolia, France for Tevan® Sil in drinking water distribution systems
Saur, France for Tevan® Sil in drinking water distribution systems
Grampian, UK for Tevan® Sil in water systems for broilers
Culligan, UK for Tevan® Sil in water softeners
Glaxo-Smith-Kline in all Europe for Tevan® QA 80 for clean rooms
City of Saarbrücken, Germany for Tevan® P.A.C. in drinking water distribution systems presenting to high levels in coli and in proteus
CONCLUSIONS
Tevan® disinfecting agents and Herlisil®: a Superior Approach to Oxidative Treatments
1. Broad activity spectrum: destroys or inhibits virtually all viruses, bacteria, fungi, algae & protozoa's
2. Speed: active within short contact time (minutes) 3. No known development of resistance in micro-organisms 4. Active on biofilms 5. 100% degradable + non-toxic for the environment and superior organisms 6. No residual byproducts 7. Persistence of action after product application 8. Active on broad pH range 9. Selective action: targeting of specific micro-organisms 10. Long-term stability (stable up to 960C) 11. Weak corrosive effect on water pipes and other facilities 12. Formulations come so far in 3 different forms: liquid, aerosol, gel 13. Applicable to all environments: water, air, surfaces, instruments, etc.
FAST DIAGNOSTIC (1 hour max.) USING BIOCHEMICAL LUMINESCENCEDetermination of: - Overall pollution (COD measurement)
- Biological pollution (ATP measurement) - Toxic pollution - Specific pollution (specific germs determination)
SAFE AND ENVIRONMENTAL FRIENDLY TREATMENT AND PREVENTION - Use of chlorine and metal free formulations based on natural actives.
UNDER DEVELOPMENT FROM DIAGNOSTIC TO
TREATMENT AND PREVENTION
UNDER DEVELOPMENTWATER FILTRATION & DISINFECTIONPrinciple: filtration on active coal combined with metallic silver– Homogeneous carbon particle size = 1 mm– Homogeneous porosity in the particles = 20-30 A– Thin layer of Ag0 deposition (cold plasma technique at 9000C)– At the boundary Ag0/carbon, silver carbides are formed (Ag2C, AgC, AgC2)– The silver is not released from the carbon filter into the filtered water– The silver plays the role of disinfectant– The adsorption capacity is huge (2000 m2 / g as per BET measurements)
Forecasted applications:- Legionella pneumophila (air conditioning)- Pseudomonas solanacearum (affecting vegetables in greenhouses)– Bulkodoria solanacearum (affecting vegetables in greenhouses)– Aquaculture (shrimps, fishes)– Livestock
Recommended