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TBLI CONFERENCE ASIA 2008 BANGKOK, THAILAND Tevan BV – the Netherlands Website: www.tevan.com CEO : M.L. GAETHOFS R&D : Dr. Ir. P. GUIOT

ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

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Pierre Guiot, Director Research and Development, Tevan B.V., The Netherlands

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Page 1: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TBLI CONFERENCE ASIA 2008 BANGKOK, THAILAND

Tevan BV – the NetherlandsWebsite: www.tevan.com

CEO : M.L. GAETHOFSR&D : Dr. Ir. P. GUIOT

Page 2: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

CHLORINE FREE TEVAN®SIL = HERLISIL®

AND CHLORINE AND METAL FREETEVAN® QA

TEVAN® PANOX TEVAN® PANOXO

Page 3: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

1.PHYSICAL, CHEMICAL and

BIOLOGICAL ASPECTS

Page 4: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

HYDROGEN PEROXIDE A NATURAL GERM KILLER

Cells involved into the immune system produce hydrogen peroxide

Hydrogen peroxide is thus a natural germ killer

Outside of the immune system hydrogen peroxide needs synergy

Page 6: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

PREVIOUS SYNERGY WITH SILVER

Silver modifies proteins

Catalase is thus neutralized

Hydrogen peroxide can exert its full action

Silver adsorbs on the germ’s membrane and modifies the membrane potential

WHO recommendation =0.1 mg Ag / L water

Ag body retention rate =0-10%Calculus of Ag2S are

formed which are eliminated from the body

Nevertheless, silver is considered as a heavy metal and its future is questionable vs annex 1 of 98/8/EEC (Ag is already banned in E and P)

Page 7: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

HERLISIL®Registered in B, NL, F, E, P, GB, D, CH, PL, Ma, Tun, Eg

NF T 72 18015 min.2%-Enterovirus polio-Orthopox virus-Human adenovirus

Virus

-60 min.10%-Naegleria fowleriAmoeba

NF T 72 23160 min.1%-Bacillus subtilis-Bacillus cereus-Clostridium sporogenes

NF T 72 23120 min.10%-Bacillus subtilis-Bacillus cereus-Clostridium sporogenes

Spores

EN 165015 min.15%-Aspergillus niger-Candida albicans

Fungi

NF T 301IMO

5 min.15 min.

0.05%0.25%

-Listeria monocytogenes-Escherichia coli

EN 13 62324 hours0.02%-Legionella pneumophila

EN 13 6235 min.2%-Legionella pneumophila

EN 12765 min.0.1%-Legionella pneumophila

EN 12765 min.14%-Pseudomonas areuginosa-Staphilococcus aureus-Escherichia coli-Enterococcus hirea

Bacteria

NormsTimesConcentrationsOrganismsSpecies

Page 8: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN®SILWELLS REHABILITATION

CLEANING with TEVAN® RAPID TWB (mix of organic and mineral acids, surfactants)

DECONTAMINATION with TEVAN® SIL @ 200 ppm, 24 hours.

RESULTSProblems due to E. coli and Pseudomonas presence are solved

Page 9: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® SIL IN COOLING TOWER PIPES

‘EFFECT ON BIOFILM’

Tevan® Sil @ 100 ppm for 18 hours

and then @ 500 ppm for 1 additional hour within the glass made pipe’s flow

@ DSM, NL

Page 10: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® SIL ON REVERSE OSMOSIS MEMBRANES @ VITENS, NL

A constant injection of TEVAN® SIL @ 3 ppm

prevents membrane clogging and enables a

constant water flow in the water installations

Page 11: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

3.OTHER SYNERGIES

Page 12: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

OTHER SYNERGIES

Quaternary ammoniumsAdsorption on membranes

PeracidsOxidizes SH, NH2, Open double bonds

Fatty oxo aminesActive wetting agents (innovative)

Essential oils (terpenic skeleton) Active fragrances (innovative)

Page 13: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

3.1.TEVAN® QA’s

PEROXIDE, QUATERNARY AMMONIUM

Page 14: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® QA 250

Derived from EN 16505 min.3%-Saccharomyces cerevisiae-Saccharomyces diastaticus

Yeasts

EN 12765 min.4%-Candida albicansFungi

NF T 72 30130 min.10%-Mycobacterium tuberculosis

Mycobacteria

Derived from EN 12765 min.3%-Lactobacillus brevis-Pediococcus damnosus

EN 12765 min.4%-Pseudomonas aeruginosa-Staphilococcus aureus-Escherichia coli-Enterococcus hirea

Bacteria

NormsTimesConcentrationsOrganismsSpecies

Page 15: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

MULTI INDUCED EVAPORATIONTECHNOLOGY

Aerosolisation of TEVAN® QA 80 with CLIM O’ MEDIC enabled good results in laboratories and manufacturing places

Page 16: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® QA 80@ Glaxo Smith Kline, Belgium

Treatment of clean rooms and SAS used for vaccines manufacturing in B, F, D, H, USA, CND

Aerosolisation @ 12 g / m3

Droplets of < 10 µm

A Δ Log reduction of 6 is required and obtained for very resistant germs

TEVAN® QA 80 ranked first among 25 products

Page 17: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® QA 80@ Bayer Crop Science, Belgium

Aerosolisation Metatecta Cy. device = Clim’O Medic®

Rooms = from 50 to 150 m3

Droplets = 5-10 µm Time = 45 min. RT Dispersed amount = 10 g / m3

Δ Log > 7 even under tables and inside cabinets For:

– Bacteria = Gram-negative Agrobacterium

Page 18: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® QA 80@ Virco (Johnson & Johnson), Belgium

Aerosolisation Metatecta Cy. device = Clim’O Medic®

Rooms = 60 m3

Droplets = 5-10 µm Time = 45 min. RT Dispersed amount = 10 g/m3

For : HIV’s DNA which is destroyed at 96 %

Page 19: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

3.2.TEVAN® PANOX

PEROXIDE, PERACID, FATTY OXO AMINEINNOVATIVE: COMBINATION OF 3 ACTIVES

Page 20: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXRegistered in F, GB, D, CH

PASTEUR INSTITUTE FRANCE, 2005/2006 test results

NF T 72 18015 min.2%-Enterovirus polio-Orthopox virus-Human adenovirus

Virus

AOAC(FDA approved in USA)Minntech lab.

Δlog5 5 min. Δlog6 10 min.Δlog7 20 min.

3%-Mycobacterium terraeMycobacteria

NF T 72 30130 min.5%-Bacillus subtilis-Bacillus cereus-Clostridium sporogenes

Spores

EN 165010 min.0.5%-Tricophyton mentagrophytes

EN 165015 min.2%-Aspergillus niger-Candida albicans

Fungi

EN 127610 min.0.1%-Salmonella typhi

EN 13 62324 hours0.02%-Legionella pneumophila

EN 13 6235 min.1%-Legionella pneumophila

EN 127624 hours0.02%-Legionella pneumophila

EN 127660 min.0.05%-Legionella pneumophila

EN 12765 min.0.1%-Pseudomonas aeruginosa-Staphilococcus aureus-Escherichia coli-Enterococcus hirea-Legionella pneumophila

Bacteria

NormsTimesConcentrationsOrganismsSpecies

Page 21: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXStudy on biofilm at TNO, NL

Control A biofilm hosting Pseudomonas aeruginosa was formed on a

stainless steel coupon of 0.8 µm roughness A 5 min. water treatment was achieved The coupon was rinsed with 1 m3 water / m2 surface / hour The biofilm stayed on the coupon

Test A biofilm hosting Pseudomonas aeruginosa was formed on a

stainless steel coupon of 0.8 µm roughness A 5 min. treatment with TEVAN® PANOX 1% in water was

achieved The coupon was rinsed with 1 m3 water / m2 surface / hour The biofilm was removed from the coupon

Page 22: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXStudy on biofilm at TNO, NL

Control After a 5 min. water treatment followed by a water rinsing

(1 m3 water / m2 surface / hour), the stainless steel coupon (0.8 µm roughness) was dyed with syto 9 and propidium

The Pseudomonas aeruginosa colonies are well apparent

Test After a 5 min. treatment with a 1% concentration of TEVAN®

PANOX followed by a water rinsing (1 m3 water / m2 surface / hour), the stainless steel coupon (0.8 µm roughness) was dyed with syto 9 and propidium

The Pseudomonas aeruginosa colonies are removed

Page 23: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXNATURAL WATER EXTRACTION

@ Nestlé Waters Vittel, France

Strains tested and methods used are specific to Nestlé

Product was at 2% with 30 min. contact

A Δlog reduction of 5.5 is obtained for all strains

TEVAN® PANOX is the best product ever tested by Nestlé

Page 24: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXSpore forming bacteria Clostridium perfringens

on working surfaces in slaughterhouses @ Wouters, NLFormulation @ 0.33% overnight

00>900Conditioned meat warehouse

000Carving place

000Slaughter place

After 5 weeks treatmentcfu/100 cm2

After 3 weeks treatmentcfu/100 cm2

After 1 week treatmentcfu/100 cm2

Location

Page 25: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

MULTI INDUCED EVAPORATION TECHNOLOGY

Aerosolisation of TEVAN® PANOX with CLIM O’ MEDIC enabled good results in laboratories and hospital rooms

Page 26: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXAerosolisation @ 33% @ Virco (Johnson & Johnson), Belgium

• Device = Clim’O Medic® (Metatecta Cy.)• Room = 60 m3

• RT• Droplets = 5-10 µm• Amount = 10 g/m3

• For : HIV’s DNA which is destroyed at 100%

Page 27: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXAerosolisation @ 33%

@ Heilig Hart Hospital with the help of the University of Louvain B

Hospital room including bath room = 50 m3

Device = Clim’O Medic (Metatecta) in the bedroom itself

RT = 220C Time = 30 minutes Droplets = 5 – 10 µm Dispersion = 16 g / m3

Organisms = Staphylococcus aureus, Aspergillus niger, Geobacillus stearothermophilus

ΔLog 3 !ΔLog 3.5 !ΔLog >5

S aureusA nigerG stearo

Within the bathroom cabinet

ΔLog > 7ΔLog 3.5 !ΔLog >5

S aureusA nigerG stearo

Within the bedroom cabinet

ΔLog > 7ΔLog > 6ΔLog > 5

S aureusA nigerG stearo

Floor, walls, ceiling

Page 28: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXDEFRA approved disinfectant since early 2007

DEFRA = UK DEPARTMENT of ENVIRONMENT, FOOD and RURAL AFFAIRS

1%SalmonellaGeneral

2%ParamyxovirusPoultry Newcastle

1%AphtovirusFoot & mouth

TEVAN® PANOX

OrganismDisease

Page 29: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

3.3TEVAN® PANOXO

PEROXIDE, PERACID, FATTY OXO AMINE, ESSENTIAL OIL

INNOVATIVE: COMBINATION OF 4 ACTIVES

Page 30: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

NF T 72 18030 min.60%-Enterovirus polio-Orthopox virus -Human adenovirus

Virus

NF T 72 30130 min.80%-Bacillus subtilis-Bacillus cereus-Clostridium sporogenes

Spores

EN 165010 min.40%-Tricophyton mentagrophytes

EN 165015 min.40%-Aspergillus niger-Candida albicans

Fungi

EN 127610 min.10%-Salmonella typhi

EN 12765 min.20%-Pseudomonas aeruginosa-Staphilococcus aureus-Escherichia coli-Enterococcus hirea

Bacteria

NormsTimesConcentrationsOrganismsSpecies

TEVAN® PANOXORTU for SURFACE TREATMENTS

PASTEUR INSTITUTE FRANCE, 2005/2006 test results

Page 31: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXO GELInnovative RTU for vertical surface and ceiling treatments, test 1

id.30 min.Porcelainid.30 min.Aluminumid.30 min.Copper

id.30 min.Stainless steel

id.30 min.Galvanized steel

Doesn’t sag

30 min.Plastic PVC

ResultTimeSurface

Page 32: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXO GEL @ CENTER PARK KEMPERVENNEN, NL

Innovative RTU FOR WALL AND CEILING CLEANING, test 2

Walls presenting black fungal marks Application of TEVAN® PANOXO GEL @ RT for 30 minutes Rinse off No mark anymore

Page 33: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

TEVAN® PANOXORTU in agriculture (fungus fusarium oxysporum on tulip bulbs)

@ ACN, NLUltrasonic generator, droplets 1µm ,250C, RH 70%, 40 min.

1TEVAN® PANOXO

1.08Jet 5 1%

1.33Formaline 10%

4.83Formaline 1%

Treatments

14.33On rinsed and dried contaminated bulbs

25.33In contaminated water

0.5In original uncontaminated water

Average cfu’sAssays

Page 34: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

4.COMPARISON, APPLICATIONS,

CONCLUSIONS, REFEREES

Page 35: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

DISINFECTING AGENTS COMPARISON

Quats Phenolics Aldehydes Chlorine Hydrogen Stabilizedperoxide hydrogen

peroxideSpectrum Semi broad* Broad Broad Semi broad* Broad Broad

Contact time Short Long Long Short Long Short

Efficacy Semi good* Poor Good Semi good* Poor Good

Toxicity Moderate Moderate High Moderate Low Low

Residue Yes Yes Yes Yes No No

Corrosion Low Moderate Low High Low Low to Moderate**

Environment Poor Poor Poor Poor Good Good

Odour No Yes Yes Yes No Yes/No**

Biodegradation 70% 85% 90% 100% 100%in 20 days in 20 days in 20 days seconds seconds

Action on biofilm No No No No Yes*** Yes***

• * More and more germs are presenting resistance• ** Depending on the ingredients• *** H2O2 produces micro turbulences through the production of gaseous oxygen

• Source: Tevan BV compilation 2003

Page 36: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

SYNERGISED HYDROGEN PEROXIDE APPLICATION FIELDS

WATER SYSTEMS Drinking waters (public, domestic, transport carriers) Industrial waters (cooling towers, air conditioning, sprinklers) Waste waters Still waters Sport & Recreation (swimming pools, fountains)

AGRICULTURE Transport materials Watering devices, irrigation, hydroponic cultures Seeds, bulbs Vegetables, fruits, flowers Greenhouses

LIVESTOCK Potable water distribution for animals Aquaculture

SURFACES and DEVICES Hospital theatres, medical tools, dentistry, clean rooms / broilers, hatcheries, stables, pigsties, etc. Metallurgy

FOOD and BEVERAGE Breweries, dairies, slaughterhouses, vintage barrels, soft drinks Baker’s & confectioner’s

Page 37: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

SOME NUMBERS

From Kaiser http://www.hkc22.com/waterdisinfection.html Water world market in 2010 = 412 billion $

From Ecodis: Water disinfection = 7.95 billions $

From the biocides information services: Global biocides market = 84 billions $ In aquaculture = 9.42 billions $ For metallic surfaces = 9.15 billions $ In cooling towers = 87.3 millions $

From Herli-France 31 255 wells in France

From society statistics for nosocomial diseases: 1.71 billions $ spent in USA and still 20 000 deaths/Y

Nosocomial diseases in France: 800 000 infections and 10 000 deaths/Y

Page 38: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

REFEREES Du Pont de Nemours, Belgium for Tevan® Sil in cooling towers water

Générale des Eaux, France for Tevan® Sil in drinking water distribution systems

Veolia, France for Tevan® Sil in drinking water distribution systems

Saur, France for Tevan® Sil in drinking water distribution systems

Grampian, UK for Tevan® Sil in water systems for broilers

Culligan, UK for Tevan® Sil in water softeners

Glaxo-Smith-Kline in all Europe for Tevan® QA 80 for clean rooms

City of Saarbrücken, Germany for Tevan® P.A.C. in drinking water distribution systems presenting to high levels in coli and in proteus

Page 39: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

CONCLUSIONS

Tevan® disinfecting agents and Herlisil®: a Superior Approach to Oxidative Treatments

1. Broad activity spectrum: destroys or inhibits virtually all viruses, bacteria, fungi, algae & protozoa's

2. Speed: active within short contact time (minutes) 3. No known development of resistance in micro-organisms 4. Active on biofilms 5. 100% degradable + non-toxic for the environment and superior organisms 6. No residual byproducts 7. Persistence of action after product application 8. Active on broad pH range 9. Selective action: targeting of specific micro-organisms 10. Long-term stability (stable up to 960C) 11. Weak corrosive effect on water pipes and other facilities 12. Formulations come so far in 3 different forms: liquid, aerosol, gel 13. Applicable to all environments: water, air, surfaces, instruments, etc.

Page 40: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

FAST DIAGNOSTIC (1 hour max.) USING BIOCHEMICAL LUMINESCENCEDetermination of: - Overall pollution (COD measurement)

- Biological pollution (ATP measurement) - Toxic pollution - Specific pollution (specific germs determination)

SAFE AND ENVIRONMENTAL FRIENDLY TREATMENT AND PREVENTION - Use of chlorine and metal free formulations based on natural actives.

UNDER DEVELOPMENT FROM DIAGNOSTIC TO

TREATMENT AND PREVENTION

Page 41: ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

UNDER DEVELOPMENTWATER FILTRATION & DISINFECTIONPrinciple: filtration on active coal combined with metallic silver– Homogeneous carbon particle size = 1 mm– Homogeneous porosity in the particles = 20-30 A– Thin layer of Ag0 deposition (cold plasma technique at 9000C)– At the boundary Ag0/carbon, silver carbides are formed (Ag2C, AgC, AgC2)– The silver is not released from the carbon filter into the filtered water– The silver plays the role of disinfectant– The adsorption capacity is huge (2000 m2 / g as per BET measurements)

Forecasted applications:- Legionella pneumophila (air conditioning)- Pseudomonas solanacearum (affecting vegetables in greenhouses)– Bulkodoria solanacearum (affecting vegetables in greenhouses)– Aquaculture (shrimps, fishes)– Livestock