1.Weed Resistance Management Dr. Hermann Stuebler Head of Weed Control Research Monheim, Germany September 5, 2013

2. Effective weed control: Essential for global production of food and feed Annual Press Conference 2013 Weed Resistance Management September 5, 2013Page 2 3. But current agricultural practices are resulting in weed resistance Page 3 Growing exponentially at a global scale in all crops and all continents Both broadleaf weeds and grass weeds Increasing resistance to multiple herbicide classes Effectiveness of numerous herbicide classes endangered Continued decline in herbicide diversity A paradigm shift in weed control is urgently required Annual Press Conference 2013 Weed Resistance Management September 5, 2013 4. Glyphosate resistance today threatens US crop production Page 4 caused massive development of weed shifts and resistance Dose rate x 2 x 16x 4 x 8 The exclusive reliance on Glyphosate for weed control Soybeans 1996 Soybeans 2008 Source: Bayer CropScience Annual Press Conference 2013 Weed Resistance Management September 5, 2013 5. Annual Press Conference 2013 Weed Resistance Management September 5, 2013Page 5 6. Annual Press Conference 2013 Weed Resistance Management September 5, 2013Page 6 7. Annual Press Conference 2013 Weed Resistance Management September 5, 2013Page 7 8. Fewer new herbicides are coming to market, while those that remain are becoming less effective Page 8 Source: Bayer CropScience Source: Bayer CropScience Annual Press Conference 2013 Weed Resistance Management September 5, 2013 9. Numerous herbicide target sites discovered, but more than half did not make it to the market Page 9 FPPS ADSS IMDH ZDS IGPD TrpS AMPDA DXR 7StC5Des 24StRed OSCyc GPAT CLObtI C24SMT KARI GibB ObtDM GSAT PyrDeh LyCyc CBL CGS EPSP ACCase GS Cytokinin Ox PS II Auxin PS I Uncoupling HPPD PPO ALS PDS Microtubuli Cell Division Cellulose DHPS VLCFA DXS 1950 1960 1970 1980 20101990 2000 Discovery of new development candidates Source: Bayer CropScience Annual Press Conference 2013 Weed Resistance Management September 5, 2013 10. And the pipeline for new herbicides is limited Page 10 20122010 2013 2014 indaziflamthiencarbazone- methyl and cyprosulfamide tefuryltrione triafamone bicyclopyrone aminocyclopyrachlor pyroxsulam saflufenacil HPPD PPO Auxin ALS Safener CBI 2009 2011 2015 2016 2017 2018 2019 Halauxifen Source: Bayer CropScience Annual Press Conference 2013 Weed Resistance Management September 5, 2013 11. Sharp decrease in weed control research Page 11 0 50 100 150 200 250 1990 1995 2000 2005 2010 Numberofnewa.i.applications Dow DuPont BASF Syngenta Bayer CropScience Number of new a.i. patent applications published in 2012 0 5 10 15 20 but Bayer CropScience remains committed to discovering new herbicides Industry-wide, a sharp decrease in herbicide a.i. patent applications Source: Bayer CropScience Source: Bayer CropScience Annual Press Conference 2013 Weed Resistance Management September 5, 2013 12. The next decade to benefit from Bayer CropSciences unique and diverse herbicide portfolio ... and beyond 2020, Bayer CropScience committed to developing the next generation in weed control technology Bayer CropScience All tools to manage challenges 13. Dr. Harry Strek Head of Profiling and Market Support Weed Control Biology Weed Resistance Management Monheim, Germany September 5, 2013 14. How weed resistance develops Page 14 Normal population After continued selection pressure Resistant population Development of herbicide resistance in a weed population Resistance can be delayed through a reduction in the selection pressure Resistance development is a natural evolutionary process Annual Press Conference 2013 Weed Resistance Management September 5, 2013 15. Annual Press Conference 2013 Weed Resistance Management September 5, 2013 markets Understanding key herbicide resistance mechanisms Page 15 16. Bayer: Global expertise in weed resistance Monitoring Diagnostics Outreach & Education Research & Development Molecular diagnostics Analytics diagnostics Greenhouse bioassays In-field investigation & detection Extensive expertise & knowledge base Global oversight & local know-how Breeding & trait development Resistance management New modes of actionMode of Action rotation Crop rotation Cultivation methods Page 16 Annual Press Conference 2013 Weed Resistance Management September 5, 2013 17. Monitoring weed resistance globally Page 17 Monitoring Diagnostics Research Outreach Global Oversight and local know-how Extensive expertise and knowledge base In-field investigation for detailed understanding of local situations Annual Press Conference 2013 Weed Resistance Management September 5, 2013 18. Offering the most extensive diagnostics tests Page 18 Facilities for Greenhouse Bioassays and resistance analyses Only major company using Pyrosequencing for high quality and more accurate monitoring data Tests in Greenhouse to more accurately mimic field conditions More than 3,000 samples analyzed in 2012 Delivering best possible recommendations to farmers State-of-the-art facilities from resistance research to diagnostics Monitoring Diagnostics Research Outreach Annual Press Conference 2013 Weed Resistance Management September 5, 2013 19. Page 19 Groundbreaking research in weed resistance At the forefront of weed resistance research Development of novel diagnostics technologies Genetic control of metabolic resistance Global oversight of weed resistance development ~20 cooperations with leading international experts on weed resistance Generating mathematical models to predict resistance development Discovering key factors inducing weed resistance to herbicides Monitoring Diagnostics Research Outreach Annual Press Conference 2013 Weed Resistance Management September 5, 2013 20. Page 20 Satisfying grower needs beyond 2020 Monitoring Diagnostics Research Outreach We are developing a new herbicide class for weed control and resistance management Novel and promising chemical class of HPPD inhibitors Resistance-breaking properties Excellent activity @ low doses Applicability in all major crops Herbicide tolerance traits in development Annual Press Conference 2013 Weed Resistance Management September 5, 2013 21. Page 21 Outreach and Education Extensive outreach and education programs in US, Canada and internationally Information sharing include field reports, firsthand evidence of effects of weed resistance, and advice on action plans to address the issue Monitoring Diagnostics Research Outreach Annual Press Conference 2013 Weed Resistance Management September 5, 2013 22. Protecting farmers seed investment and safeguarding yield with Liberty and Liberty Link Liberty herbicide and Liberty Link offer the only non-selective alternative to glyphosate-tolerant system Sustainable weed control: Kills weeds in a short timeframe A nonselective, contact herbicide with an unique mode of action that provides post-emergent control of more than 120 broadleaf weeds and grasses Control of ALS- and glyphosate-resistant weeds, including resistant waterhemp, pigweed, ragweed, and marestail So far no weed resistance after > 15 years in crop use in herbicide-tolerant canola Fundamental tool for solving existing and preventing future resistance problems Page 22 Monitoring Diagnostics Research Outreach Annual Press Conference 2013 Weed Resistance Management September 5, 2013 23. Page 23 Diversity is the Future THE BAYER INITIATIVE AGAINST WEED RESISTANCE Monitoring Diagnostics Research Outreach Annual Press Conference 2013 Weed Resistance Management September 5, 2013 24. Q & A