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Solid State Medical Imaging: X-ray and Endoscopy
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Overview of the technical & economic requirements for Medical Imaging applications
October 2014
Solid State Medical Imaging: X-Ray and Endoscopy
SAMPLEThe Medical Image Sensors market is expected to double over the next five years. M&A
are increasing. Discover how Medical Imaging is being reshaped!
Le Quartz - 75 cours Emile Zola - 69100 LYON-Villeurbanne
Tel: +33 472 83 01 80 - Fax: +33 472 83 01 83
Web: www.yole.fr
© 2014 • 2Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Table of content
1) Executive Summary ………………...........................p.4
2) Introduction, Definitions & Methodology …….…p.16
3) What’s Happened in the Last Two Years?...........p.39
4) Medical Image Sensor technologies overview….p.13– CCD image sensors
– CMOS image sensors
– Amorphous silicon flat panels
– Technologies comparison
– Specificity of X-ray imaging
5) Medical Image Sensors Market Overview ...…….p.35– Global imaging market
o Forecasts in revenue/volume
– Endoscopy market
o Split by technology (CCD & CMOS)
o Forecasts in revenue/volume/wafer shipments
– X-ray imaging marketo Split by technology (CCD, CMOS and a-Si)
o Forecasts in revenue/volume/wafer shipments
– CCD medical image sensors market
o Forecasts in revenue /volume split by product category
– CMOS medical image sensors marketo Forecasts in revenue and in volume split by product
category
– a-Si flat panel sensors market
o Forecasts in revenue and in volume split by product
category
6) Market segmentation ....................................p.64– Market drivers by segment
– Technology positioning
7) Product categories description .....................p.72– Focus on endoscopy applications
o Rigid endoscopes
Market revenue/volume
Market drivers
Players
Technologies
o Flexible endoscopes
Market revenue/volume
Market drivers
Players
Technologies
o Camera pills
Market revenue/volume
Market drivers
Players
Technologies
o Disposable endoscopes
Market revenue/volume
Market drivers
Players
Technologies
-
© 2014 • 3Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Table of content
– Focus on X-ray imagingo Dental X-ray imaging Market revenue/volume
Market drivers
Players
Technologies
o Medical X-ray imaging Market revenue/volume
Market drivers
Players
Technologies
8) Medical Image Sensors Supply Chain Analysis..p.267– Rigid endoscopes
– Flexible endoscopes
– Camera pills
– Disposable endoscopes
– X-ray intraoral detectors
– X-ray flat panel detectors
9) Medical Image Sensors Value Chain Analysis...p.279– Disposable endoscope value chain
– Flexible endoscope value chain
– Rigid endoscope value chain
– CMOS camera pill value chain
– A Si flat static panel detector value chain
– A Si flat dynamic panel detector value chain
– CMOS panel intra oral detector value chain
10) Medical Image Sensors Challenges….p.287
11) Summary and Conclusions………………p.299
© 2014 • 4Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Some Companies Cited in the Report
AGFA, Alcon, Austria Microsystems, CMOSIS (Awaiba), BioVision Technologies LLC , Caeleste, CapsoVision Inc., Carestream Health, Circon, Cyber Medical,
Dongbu Hitek, e2v, EndoOptiks, Escalon, FiberTech, Fujifilm, Fujinon, General Electrics, GI View, Giotto, Given Imaging, GMM, Hamamatsu, Hitachi, Hologic, Hoya Life Sciences, Imix, IntroMedic, Intuitive Surgical ,Invendo Medical, ISDI,
Italray, Jinshan Group, Karl Storz, Konica Minolta, Medigus, Micro-Imaging Solutions, Olympus, ON semiconductor (Cypress), OSAT, VT & Aptina, Palodex,
Panasonic, Perkin Elmer (Dexela), Philips, Primax, Pyxalis, RF Systems labs, Richard Wolf, Samsung, Shimadzu, Siemens, Sony, STMicro, Stryker, Swissray,
Teledyne DALSA, Toshiba, TowerJazz, Trixell, True sense imaging, TSMC, Varian, Vatech Human ray, Villa, VIM’S, X-Fab, Ziehm Imaging…
© 2014 • 5Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Medical Image SensorsScope of the report
• This report will focus exclusively on direct Imaging applications.
• Microscopy is excluded from that report because is hardly ever used in vivo, primarily it is used in vitro.
• Indirect imaging applications will not be developed in this report as their evolution rather relies on softwareprocessing optimization.
Direct Imaging / Hardware DependantIndirect Imaging / Software
Dependant
Microscopy Endoscopy X-Ray based methods MRIUltrasound
ImagingNuclear
Medicine
Stan
dal
on
e
DisposableCamera
pillsDisposable endoscopes
Re-usableFlexible
endoscopesRigid
endoscopes
X-Ray imagers for intra-oral
imagingX-Ray imagers for 3D & large area imaging
Doppler ultrasound
Integrated into a large system
MicroscopesX-Ray imagers for 2D extra-oral imaging
CTMRI syste
mPET Scan
Application
Optical Imaging X-ray Imaging
© 2014 • 6Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Image Sensor Technologies by Market
The table below links applicative markets and Medical Image Sensor (MIS) technologies:
CCD MIS CMOS MIS A-Si MIS
Camera pillsmarket
X X
Disposable endoscopes market
X
Flexible endoscopes market
X X
Rigid endoscopes market
X X
intra-oral imagingmarket
X
X-ray 3D CBCT extra-oral imaging
X X X
2D extra-oralmarket
X
3D & large areamarket
X X X
En
do
sc
op
y
Ap
pli
ca
tio
n
X-R
ay I
ma
gin
g
Ap
pli
ca
tio
n
© 2014 • 7Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Value Chain Analysis
Technology penetration per markets and market shares are provided.
© 2014 • 8Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Market Forecast for equipment / sensorsIn value / volume / wafers shipments
Instruments Markets…
Sensors Markets…
…splited by Medical Image Sensors technologies
© 2014 • 9Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Value Chain Analysis
Detailed Value Chains have been added
© 2014 • 10Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Detailed Supply Chain
Updated supply chain are available for each
product category
© 2014 • 11Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Supply Chain evolution is described
Our analysis on the supply chain evolution and the potential next targets are presented
© 2014 • 12Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
Technology TrendsX-Ray Imaging Technologies Overview
CCD Image
Intensified
Camera
a-Si FPD
CMOS FPD
• Three main components : 1. Scintillator to convert x-ray into visible
light
2. Fiber Optic Taper for mignification
3. CCD sensor for light to electron
conversion
• High resolution
• Buky, low field of viewCCD sensor
Fiber Optic Taper
Scintillator
X-Ray
ADC Processing
• Two components: 1. Scintillator to convert x-ray into visible
light
2. a-Si matrix array: passive pixels
(photodiodes convert light into electrons +
one TFT switch per pixel)
• Very large panel, simple, economical
• Low resolution, image lag, slow
X-Ray
Scintillator
a-Si array
• Two components: 1. Scintillator for x-ray to visible light
conversion
2. CMOS image sensor: active pixel
(photodiodes convert light into electrons +
several transistors per pixel convert charges
to voltage, on-pixel ADC & amplifier)
• High speed/resolution
• Limited size needs sensor tiling,
expensive
X-Ray
Scintillator
CMOS image
sensor
+
-
+
-
+
-
© 2014 • 13Medical Imaging September 2014 Copyrights © Yole Développement SA. All rights reserved.
About The Author
Benjamin ROUSSEL
He is leading the MedTech activity (microfluidic and medical technologies) at Yole Développement. He holds a pharmacy diploma from the University Claude Bernard Lyon, complemented by a master degree in Technology and Innovation Management from EM Lyon Business School.Contact: [email protected]