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Presentation on HeLa cells and the Life of the Mind session by Dr. Peterson.
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Life of the Mind 2011
Facilitator Training Presenter: Cynthia Peterson
Questions to consider…
What is the science of Cell Biology?
What was the breakthrough with HeLa cells?
What milestones in cell biology studies were possible because of HeLa cells?
How does one scientist react to this book?
What about research at the University of Tennessee?
Questions to consider…
What is the science of Cell Biology?
What was the breakthrough with HeLa cells?
What milestones in cell biology studies were possible because of HeLa cells?
How does one scientist react to this book?
What about research at the University of Tennessee?
What is the science of Cell Biology?
Work with cells in laboratory setting
Learn about cell structure, division, organization, normal and disease processes
Microscopy gives an up-close picture of the cells
Important step in drug development
What is the science of Cell Biology?
Work with cells in laboratory setting
Learn about cell structure, division, organization, normal and disease processes
Microscopy gives an up-close picture of the cells
Important step in drug development
What is the science of Cell Biology?
Questions to consider…
What is the science of Cell Biology?
What was the breakthrough with HeLa cells?
What milestones in cell biology studies were possible because of HeLa cells?
How does one scientist react to this book?
What about research at the University of Tennessee?
What was the breakthrough with HeLa Cells?
Human cells cultured for the first time! (Gey had cultured other species and had worked for over 20 years with this aim)
Cancer researchers considered cultured human cells to hold the key to discovering a cure
HeLa cells are a “workhorse” for cell biology: easy to grow, ideal for microscopy, transfection
Provided a model cell line for studying normal cellular processes as well as many diseases
Original Research on Polio Infection
Infected Cells
Uninfected Cells
Questions to consider…
What is the science of Cell Biology?
What was the breakthrough with HeLa cells?
What milestones in cell biology studies were possible because of HeLa cells?
How does one scientist react to this book?
What about research at the University of Tennessee?
What milestones in cell biology were possible because of HeLa cells?
Polio infection process and vaccine development
Advances in microscopy
Research to isolate single cells and eventually to establish clonal cell lines
Methods established for chromosome spreading and karyotyping
Ongoing research on telomerase (Nobel Prize 2009)
New siRNA technologies for gene knockdowns
What milestones in cell biology were possible because of HeLa cells?
Questions to consider…
What is the science of Cell Biology?
What was the breakthrough with HeLa cells?
What milestones in cell biology studies were possible because of HeLa cells?
How does one scientist react to this book?
What about research at the University of Tennessee?
How does one scientist react to this book?
Medicine and Science History of modern medicine
Doctor/Patient Relationship
Ethics, Values, and Civility Research Ethics
Legal Issues
How does one scientist react to this book?
Social, Economic and Political Aspects
Socioeconomic status
Race, class and gender
Research Journalism
Finding a passion
Questions to consider…
What is the science of Cell Biology?
What was the breakthrough with HeLa cells?
What milestones in cell biology studies were possible because of HeLa cells?
How does one scientist react to this book?
What about research at the University of Tennessee?
What about research at the University of Tennessee?
HeLa cells are used by many researchers across campus….. Where is a protein in the cell? What are its binding partners? How does localization change with cell cycle? Use transfection methods to introduce new genes into the
cell Use knockdown technologies to selectively reduce levels of
specific proteins
Examples from my own department Mobility of proteins in membrane Localize proteins within nuclear envelope Finding specific DNA/protein interactions
An example from an undergraduate researcher
Questions???
