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IDEAL
PATHOPHYSIOL
OGY:
pathogenesis
metastasis
angiogenesisACTUAL CONCEPT MAP
PATIENT TC:
hemothorax
ascites
profound anorexia
PREDISPOSING FACTORS
Hello there!
PRECIPITATING FACTORS
Biologic agents?
Physical agents?
Chemical agents?
Diet?
“Central Dogma of Molecular Biology”
Hello! These are
some kinds of
mutations.
Ovarian proto-oncogenes:
ras
akt-2
Ovarian tumor
suppressor genes:
BRCA2
BRCA1
Mechanisms of Metastasis
peritoneal seeding lymphatic spread hematogenous spread
Angiogenesis
Where did the ASCITES come from?
• Vascular permeability
factor
• ↑ permeability
• Fluids leak into peritoneal
cavity
• Diaphragm lymphatics obstructed
• ↓ drainage of fluid from
peritoneal cavity
ASCITES
Where did the HEMOTHORAX come from?
• blood vessels destroyed
• cancer cells and WBC in
pleural cavity
• pleural cavity cells pull
in more fluids
HEMOTHORAX
Where did the ANOREXIA come from?
• immune cellscytokines
• cytokineshypothalamus
anorexia
• anorexialow food & fluid intake
Anorexia &
Muscle Wasting
The end! Thanks for listening!