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Presentation from 10/15/13 on Nano-Materials, highlighting those used in surgical meshes. Retectix founder Matt MacEwan explains how they make nano-materials and why they solve such a major problem for so many. Join OpenlyDisruptive.org for live access to more disruptive innovation events.
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Property of Retectix, LLC. Confidential. © 2013.
Matthew MacEwan, MD, PhD* Founder / President
A COMMON PROBLEM
1 of 4
THE CLINICAL PAIN
>40% FAIL
OUTDATED TECHNOLOGY
Woven Surgical Mesh
OUTDATED TECHNOLOGY
≠ Macroscopic Nanoscopic
Woven Mesh Human Tissue
A BETTER SOLUTION?
≠ Nanoscopic Nanoscopic
Synthetic, Non-Woven Material? Human Tissue
?
Man
ufac
turin
g P
roce
ss: B.) Collector:A.) Instrumentation: C.) Resulting Fibers
Radial
Random
+
-
+
-
Planar Collector
Circular Collector +Central Point Electrode
Nanofiber Deposition Nanofiber Monolayers Surgical MeshLayer AssemblyAPPLIED NANOTECHNOLOGY
= Nanoscopic Nanoscopic
RETECTIX Nanofibers Human Tissue
?
BIO-INSPIRED DESIGN
AlignedRandom
NOVEL BIOLOGICAL PROPERTIES
CELLULAR MODULATION
THE NEXT STEP?
BENCHTOP TO BUSINESS
2.3 B market
>$2 Billion Market / ASP $500
(1) Millennium Research Report, (2) IMS 2010/2011
SCALING UP PRODUCTION
B.) Collector:A.) Instrumentation: C.) Resulting Fibers
Radial
Random
+
-
+
-
Planar Collector
Circular Collector +Central Point Electrode
Nanofiber Deposition Nanofiber Monolayers Surgical Mesh Layer Assembly
• Proprietary method • Proprietary equipment • Proprietary process
• Proprietary patterns • Proprietary designs • Proprietary materials
• Proprietary methods • Proprietary features
• Proprietary devices • Proprietary uses and applications
INNOVATIVE SOLUTION
A new class of surgical mesh…
RAPID WOUND HEALING
Novel Method Nanomaterial Regeneration Unoperative Dura Dura Repaired with Radial Nanofiber Mesh
(Cortical view) (Cortical view) (Cortical view)
Dura Repaired with Collagen Matrix
Animal Tissue No Ingrowth Unoperative Dura Dura Repaired with Radial Nanofiber Mesh
(Cortical view) (Cortical view) (Cortical view)
Dura Repaired with Collagen Matrix
Cell Ingrowth
Manu
factur
ing Pr
oces
s: B.) Collector:A.) Instrumentation: C.) Resulting Fibers
Radial
Random
+
-
+
-
Planar Collector
Circular Collector +Central Point Electrode
Nanofiber Deposition Nanofiber Monolayers Surgical MeshLayer Assembly
Poor Healing Treated Collagen
Resistant to tears /suture pullout
0
2
4
6
8
10
12
14
16
18
DuraGen™ DuraMatrix™ DuraPatch™ Cerafix™
Su
ture
Pu
llo
ut
Str
eng
th (
N)
UNIQUE HANDLING & STRENGTH
DuraStar™
OEM Manufacturing
Research & Development Regulatory / Legal
Finished Device Manufacturer
POISED FOR GROWTH
BREAKING BOUNDARIES
Est. clinical release: Q2 2014
ERA OF MICROBIOLOGY…
… TO ERA OF NANOTECHNOLOGY
Property of Retectix, LLC. Confidential. © 2013.
RETECTIX, LLC 4633 World Parkway Circle
St. Louis, MO 63134 [email protected] www.retectix.com
