Less Until None:

A Planfor a World

without T1D

2

LESS UNTIL NONE

2

JDRF’s Vision for the Future

3

Therapies CureDelivery of Continuous Therapeutic Improvements

Side-EffectsComplicationsPatient Burden

Glycemic ControlSafety

Normal Physiology Restored

Better Safety, Fewer Side-Effects, Less Exposure to Complications

4

JDRF Research Priorities

Regenerating new beta cells

Encapsulation of alternative beta cell sources

Immune therapies

Diagnostic, measurement and imaging tools

Artificial pancreas systems

Novel insulins and other blood sugar control drugs

Diabetic eye disease

Complications prevention

Preventing the autoimmune process from ever starting

Stopping and reversing the autoimmune process early to

maintain insulin independence

5

Artificial PancreasAutomated technologies to help maintain better control of blood-glucose levels

Integrated smart technology to automate routine elements of insulin management

FDA released final guidance on pathway for commercialization of devices

6

Glucose Responsive Insulin (GRI)

Form of insulin that activated when blood-glucose levels start to rise

Simplifies life for and improves overall blood-glucose controls

JDRF competition underway to accelerate progress on GRI

7

EncapsulationEasily implantable Beta cells or islets surrounded by a protective shield/capsule

Able to sense glucose levels and produce insulin as needed

Hidden from the immune system to sustain normal function

Eliminating the need for immunosuppressive drug therapy

8

Regeneration

Ability to create new insulin producing cells destroyed by autoimmune attack

Creating abundant supply of Beta cells through stem cells and regeneration

Immune therapy for suspected “triggers” including viruses

9

Secondary Prevention

Preserve beta cell function in these newly diagnosed individuals

Approaches include:Reducing inflammationBoosting beta cell survival Suppressing the autoimmune attack

10

Primary Prevention

Prevent the autoimmune attack on beta cells before it starts

Approaches include:Viral vaccinesBeta Cell Autoantigen Vaccines

11

Funding Scaleand Scope

IndustryInfluence

R&DExpertise

Government Advocacy

12

Make a Difference and Get Involved!

Give generously to speed JDRF research to cure, better treat and prevent T1D.

Join a JDRF Walk, Ride, Gala or other fundraising event.

Volunteer at the local JDRF chapter. Participate in clinical research.

13

Thank you!