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Distributed Annotation System
• Developed in 1999/2000 by Lincoln Stein (CSHL) and collaborators as a GFF‐based web service.
• Biodas.org (http://www.biodas.org):• A client‐server system in which a single client integrates information from multiple servers.
• It allows a single machine to gather up genome annotation information from multiple distant websites, collate the information, and display it to the user in a single view.
General Feature Format• Genome annotations, especially structural annotations, are often stored in
GFF (General Feature Format) files.
• GFF is a simple tab‐delimited data format.
• Fields are:
<seqname> <source> <feature> <start> <end> <score> <strand> <frame> [attributes] [comments]
• See also: http://www.sanger.ac.uk/Software/formats/GFF/
DAS Concept
Reference server
Annotation server BAnnotation server A Annotation server C
Client
DAS Registry
http://www.dasregistry.org
DAS Server
• DAS request to retrieve the data sources
• http://das.ensembl.org/das/dsn
• Result:
DAS Server
• DAS request to retrieve features on a segment:• http://das.ensembl.org/das/ens_36_omim_genes/features?segment=1:1,1000000
• Result:
Das viewer
http://www.ebi.ac.uk/dasty