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IMMUNOLOGYDR. MA. TERESA S. FAJARDO
PEDIATRICSHEMATOLOGY/ ONCOLOGY
LYMPHOID ORGANSBONE MARROWTHYMUSLYMPH NODESSPLEENPERIPHERAL LYMPHOID TISSUES
BONE MARROW
SITE OF HEMATOPOEISISMOSTLY ON THE FLAT BONES AFTER PUBERTY
THYMUS
CENTRAL LYMPHOID ORGAN ACTIVE IN THE EARLY STAGES OF LIFE DEVELOPMENT AND MAINTENANCE OF PERIPHERAL LYMPHOID TISSUES ( SPLEEN , LN , MALT)
FUNCTIONS OF THE THYMUS
MATURATION OF THE PRECURSOR T- LYMPHOCYTES FROM THE BM INDUCTION OF IMMUNOCOMPETENCE
LYMPH NODES
ANATOMICAL GROUPINGS: NECK, AXILLA FEMORAL AND POPLITEAL AREAANTIGENS ARE DELIVERED VIA LYMPHATICS TO LN WHERE SPECIFIC IMMUNE RESPONSE ARE GENERATED
SPLEEN
VITAL FOR IMMUNE RESPONSE TO BLOOD BORNE ANTIGENSWASTE DISPOSAL SYSTEM ( MACROPHAGES)ASPLENIC PATIENTS ARE ALREADY RENDERED SUSCEPTIBLE TO INFECTION BY ENCAPSULATED BACTERIA
PERIPHERAL LYMPHOID ORGANS
MUCOSAL IMMUNITY IS A FUNCTION OF AGGREGATES OF LYMPHOCYTES MACROPHAGES AND ACCESSORY CELLS BENEATH THE MUCOSAL EPITHELIUMPAYER’S PATCHES IN THE SMALL INTESTINESMALT( MUCOSA ASS. LYMPHOID TISSUES)
CUTANEOUS IMMUNE SYSTEMINTRAEPIDERMAL LYMPHOCYTES LYMPHOCYTE AND ACCESSORY CELLS IN THE DERMISLANGERHAN’S CELL, AN ANTIGEN PRESENTING CELL IN THE SKIN
CELLULAR ELEMENTS OF THEIMMUNE SYSTEMLYMPHOCYTES MULTIPOTENTIAL CELLS WHICH CAN SERVE AS MEMORY AND EFFECTOR CELLS KILLER CELLS, IMMUNOREGULATORY CELLS AND IG- PRODUCING CELLS SYNTHESIZE AND SECRETE CYTOKINES
CLASSES OF LYMPHOCYTESB CELL ( BURSA/ BONE MARROW DERIVED)T CELL( THYMUS DERIVED)
NATURAL KILLER CELLS“ NULL CELLS” ( NO SURFACE MARKERS) LARGE GRANULAR LYMPHOCYTES 5 % of THE PERIPHERAL BLD LYMPHOCYTES PERFORM ANTIBODY DEPENDENT CELL CYTOTOXICITY ( ADCC) LYSIS OF TUMOR ( IMMUNOSURVEILLANCE) ANTI –CANCER RESPONSE 1ST LINE OF DEFENS IN NEONATAL HERPES VIRUS INFECTION
PHAGOCYTOSIS
PERIPHERAL DEFENSE MECHANISM AGAINST MICROORGANISMS
PHAGOCYTES
POLYMORPHONUCLEAR
MONONUCLEAR
FUNCTION OF THE PMNADHERENCE TO VASCULAR EPITHELIUM IN RESPONSE TO INFLAMMATORY MEDIATORSCHEMOTAXIS AS MIGRATION TOWARD SITE OF ANTIGEN OR MICROBIAL INVASIONKILLING OF INGESTED MICROORGANISM
FUNCTION OF THE MONONUCLEARLYMPHOCYTES INGESTION OF MICROORGANISMS AND
OTHER FOREIGN MATERIALS
EFFECTOR CELLS OF THEIMMUNE RESPONSE
EOSINOPHILS
MAST CELLS
BASOPHILS
EOSINOPHILSBONE MARROW DERIVED GRANULOCYTES WITH GRANULES CONTAINING PROTEINS THAT BINDS DYES AS EOSINPRINCIPAL EFFECTOR CELLS AGAINST HELMINTHIC PARASITES
MAST CELLS AND BASOPHILSEFFECTORS OF HYPERSENSITIVITYCARRY FC RECEPTORS FOR I g EINCREASED NUMBER OF IgE MOLECULES IN ALLERGIC PATIENTS
HUMORAL ELEMENTS OFTHE IMMUNE SYSTEMIMMUNOGLOBULIN
COMPLEMENT
CYTOKINES
CLUSTER DIFFERENTIATION ANTIGEN
IMMUNOGLOBULINS( ANTIBODIES)SERUM PROTEINS PRODUCED BY B CELLS ( SURFACE Ig) , PLASMA CELLS ( SECRETORY Ig) , COLOSTRUM , SALIVA , GIT AND UT20 % OF THE TOTAL PLASMA PROTEINS
IgM IO % OF THE NORMAL SERUM Ig
PENTAMER
LARGEST Ig
EARLIEST ANTIBODY IN RESPONSE TO Ag
IgGMOST ABUNDANT
CAN TRAVERSE THE PLACENTAL BARRIER
VITAL ROLE IN THE DEFENSE OF NEWBORN
AGAINST INFECTION
IgA SYNTHESIZED IN THE PLASMA CELLS
LOCATED IN THE SUBMUCOSA OF THE RESPIRATORY TRACT, INTESTINES, AND EXCRETORY GLANDS ANTIBODY IN PREVENTING INFECTION OF THE ABOVE ORGANS
IgD MONOMER
PRESENT IN THE SERUM IN SMALL AMOUNTS
PLAY A ROLE IN THE DIFFERENTIATION OF B CELLS
IgE PLAYS A ROLE IN PARASITIC INFECTION AND ALLERGIC REACTION
MEDIATES ACTIVATION OF THE EOSINOPHILS FOR THE IMMUNITY OF PARASITES AND IN THE LATE PHASE OF ALLERGIC REACTION
CLUSTER DIFFERENTIATIONANTIGENCELL SURFACE PROTEINS THAT IDENTIFY A CELL LINEAGE / DIFFERENTIATION STAGE ( PHENOTYPIC MARKERS )PROMOTE LYMPHOCYTIC ACTIVATION
IMMUNITY
MECHANISM INVOLVED IN THE RESISTANCE TO INFECTIOUS AND NON- INFECTIOUS FOREIGN SUBSTANCES
COLLECTIVE AND COORDINATED CELLULAR AND HUMORAL RESPONSE TO FOREIGN SUBSTANCES
TYPE 1IMMEDIATE HYPERSENSITIVITYPROTOTYPE : BRONCHIAL ASTHMAURTICARIAALLERGIC RHINITISALLERGIC CONJUNCTIVITISALLERGIC ASTHMASYSTEMIC ANAPHYLAXIS
TYPE 2ANTIBODY DEPENDENT CELLULARCYTOTOXICITYPROTOTYPE: HEMOLYTIC DISEASEERYTHROBLASTOSIS FETALISACQUIRED HEMOLYTIC ANEMIATHROMBOCYTOPENIAGOODPASTURE ‘ S SYNDROMEGRAFT REJECTIONNEUTROPENIA AND CHRONIC KERATITIS PEMPHIGUS
IMMUNE COMPLEXMEDIATED INJURYSERUM SICKNESSPOLYARTERITIS NODOSAPOST- STREPTOCCOCAL GLOMERULONEPHRITISARTHUS REACTIONRHEUMATOID ARTHRITISSLESTEVEN- JONSON SYNDROME
TYPE 4T – CELL MEDIATED/ DELAYED TYPEHYPERSENSITIVITY
PROTOTYPE : TUBERCULIN SKIN TESTAUTOIMMUNE DISEASESCONTACT ALLERGIC DERMATITISSYPHILISLEPROSYPARASITIC INFECTION