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Megapixel. DNA Replication Technology Promises Faster, More

Precise Diagnostics and Researchers Identify Seventh and

Eighth Bases of DNA

BY:CAMILO RESTREPO RODRIGUEZ

Central Dogma of Molecular Biology

'Megapixel' DNA Replication Technology Promises Faster, More Precise Diagnostics

•The new digital polymerase

chain reaction (PCR) device

uses liquid surface tension,

rather than systems of

microscopic valves, to

partition DNA samples into

arrays of 1,000,000 chambers

or more. The device enables

the direct counting of single

molecules isolated in

individual chambers.

'Megapixel' DNA Replication Technology Promises Faster,

More Precise Diagnostics• PCR is an indispensable molecular

biology technique used by

researchers to amplify or copy a

single piece of DNA millions or

billions of times.

• The technique is about repeated

cycles of heating and cooling of

the reaction to replicate segments

of DNA using a protein called DNA

polymerase.


More Precise Diagnostics• This new generation of DNA replication

technique increase the sensibility and

density more than the original technique.

• It has the capacity to identify mistakes

sequences between two little target until

by a single nucleotide variation.

• The new 'megapixel' technique set new

benchmarks in detecting rare mutations.


More Precise Diagnostics• That new discoveries is an

opportunity to diagnosis any

pathology earlier and

beginning the treatment with

more opportunities to grow up

without any genetic disease

and this approach are so

important to for the science

and improve at the new

investigators to continue with

the legacy.

NITROGENOUS BASES OF DNA AND RNA

Researchers Identify Seventh and Eighth Bases of DNA

• Those four bases have been

taken in books about science

and have formed the basis of

the growing knowledge about

how genes code for life.

• Scientists have expanded that

list from four to six.


• These last two bases called 5-

formylcytosine and 5

carboxylcytosine.

• That have been modified by Tet

proteins, molecular entities that

it function is in DNA

demethylation and stem cell

reprogramming.

• This methylation is associated

with gene silencing.


• The discovery could advance stem cell research into the

DNA changes such as the removal of chemical groups

through demethylation that could reprogram adult cells to

make them act like stem cells.


• This approach are to effective to

“return“ this person to health state.

Those new bases are so important

and are involves in diseases process

like cancer, and could be an

advanced to genetics studies because

that found could provide new tools to

erase previous methylation patterns

to reprogram adult cells.

EARLIER DIAGNOSIS

MEDICAL UTILITY• This discovery could have

important implications for

stem cell research, and it

could provide researchers with

new tools to erase previous

methylation patterns to

reprogram adult cells.

• It could also inform cancer

research, and it could give

scientists the opportunity to

reactivate tumor suppressor

genes that had been silenced

by DNA methylation.

MEDICAL UTILITY

• It could has more of precision

in measurements in

biomedical research and

diagnostics.

• The PCR it could be

transformed in routine exam

and analytical tool because is

a more economical tool, that

is that everyone hopes.

•Those advances are so important to any

camps like medicine, molecular biology

and genetics.

•There are important tools to earlier

diagnosis of many important pathologies,

that could be unrehab if it haven´t has

that diagnosis.

BIBLIOGRAPHY

• University of British Columbia. "'Megapixel' DNA replication technology promises faster, more precise diagnostics." ScienceDaily, 4 Jul. 2011. Web. 5 Aug. 2011.

• University of North Carolina School of Medicine. "Researchers identify seventh and eighth bases of DNA." ScienceDaily, 21 Jul. 2011. Web. 5 Aug. 2011.

If medicine and genetic still work together, day to day we could get more tools to know the hidden world of disease.