Folding!!!

NEW DISCOVERIES AND NEW DISCOVERIES AND PATTERNS OF PATTERNS OF CHROMOSOME CHROMOSOME ABNORMALITY ABNORMALITY

Alejandra Restrepo Ochoa

Universidad Pontificia Bolivariana

Medicine Student , 3rd semester

Teacher: Lina María Martínez Sánchez

Molecular Biology

FOLDINGFOLDING

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INTRODUCTIONINTRODUCTION

Bad folding, synthesizing and aggregation of proteins contributes to decrease the cell’s ability to live and reproduce.

In cancer is possible to see many chromosomal aberrations, but unlike normal cells, cancer cells can strongly grow and reproduce.

NEW DISCOVERIES IN NEW DISCOVERIES IN CELL AGINGCELL AGING

NEW DISCOVERIES IN CELL NEW DISCOVERIES IN CELL AGINGAGING

The researchers have quantified the effect of protein aggregation on cell aging.

Protein aggregations are important in different neurodegenerative deseases.


For the first time, they mesured the damage caused by bad folding and aggregation of proteins.


The expression of Alzheimer’s AB42 peptide in bacteria, induces protein aggregation.

COMMENTCOMMENT

I think that is important to know more about proteins and their behavior because they are involved in a lot of natural processes and diseases.

PATTERNS OF CHROMOSME

ABNORMALITY: THE KEY TO CANCER?



Many chromosomal pairs are lost or gained together across different cancer types.

As cancer advances the genome becomes more mutated.



The researchers could confirm the chromosomal aberrations that are seen in specific cancer types.


ABNORMALITY: THE KEY TO CANCER?The possibility to answer the

question about cancer’s changes, can help us to understand the characteristics of its progress.

COMMENTCOMMENT

These discoveries are very important to understand better cancer in order to find how to make it less lethal.

MEDICAL UTILITYMEDICAL UTILITY

MEDICAL UTILITYMEDICAL UTILITYEach little thing about the human

being is so complex and so well done, that is very difficult to clear up all the mysteries that it keeps.

MEDICAL UTILITYMEDICAL UTILITY

With all the knowledge about this, it will be easier to prevent and even to cure a lot of acute, chronic or lethal diseases.

MEDICAL UTILITYMEDICAL UTILITYAs we learn more about these

chromosomal aberrations, we get to be able to give a better life to people that have genetic chromosomal aberrations or cancer.

BIBLIOGRAPHYBIBLIOGRAPHY“New discoveries in cell aging”,

Science Daily Journal, internet edition, january 2012, http://www.sciencedaily.com/releases/2012/01/120123101831.htm

“Patterns of chromosome abnormality: the key to cancer?, Science Daily Journal, internet edition, january 2012, http://www.sciencedaily.com/releases/2012/01/120123115527.htm

THANKSTHANKS

Technology

Folding!!!