YOU SOLVING THE PROBLEMS OF YOUR PATIENTS.

THE PROFESSIONAL TREATMENT FOR HYPERSENTIVITY.

CONTAINS NANO- HYDROXYAPATITE

Desensitizing andRemineralizing Paste

YOU SOLVING

DENTINHYPERSENTIVITY

Efficiency and longevity of the treatmentThe nanoparticles of hydroxyapatite restore the

microstructure, the chemical composition of the teeth and

their functionality.

How does the pain occur?Heat, cold and citric food, sweets, air and pressure are

stimuli that may cause the movement of fluids in the

dentin tubules, increasing the pressure inside of them,

which stimulates the nerves inside the tooth, resulting in

the pain.

Gingival recession

How Desensibilize Nano P obliterates the tubules?The nanoparticles of hydroxyapatite are deposited in

the dentin tubules, obliterating them, which difficult the

access of the external stimuli to the pulp and eliminates

the painful symptoms.Nano-hydroxyapatite

Efficiency and longevity of the treatmentThe obliteration of the tubules is potentialized/stabilized

by the action of the saliva on the nanoparticles of

hydroxyapatite. Such obliteration remains intact even after

the exposure to acids.

Action of the saliva

How Desensibilize Nano P remineralizes?The nanoparticles of hydroxyapatite penetrate in the tooth,

integrating in it, and acting as a system of replacement and

release of calcium and phosphates ions, with acid resistance

similar to the hydroxyapatite of the natural tooth.

Microcracks/porosities in the enamel

Remineralizing action

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TOOTH REMINERALIZING

ADVANTAGES OF THE NANO P TECHNOLOGY

Desensibilize Nano P is a bifunctional paste developed to treat tooth hypersensitivity effectively and durably and to remineralize the dental structure.

Desensibilize Nano P contains the exclusive Nano P technology, based on nanostructured calcium phosphate in the form of nanoparticles of hydroxyapatite, which work in a biocompatible way in the obliteration of the exposed dentin tubules, in the enamel microcracks and in the remineralization of the dental structure, restoring the microstructure,

the chemical composition and the functionality of the tooth.

The nanoparticles of hydroxyapatite present a higher bioactivity, due to its small diameter and its morphology which increases its superfi cial area. In addition, its capacity of hydration and wetability allow it to release ions calcium and phosphates to the tooth in the adequate concentrations and speeds. This way, the presence of the nano-hydroxyapatite confers differentiated and innovative properties to the Desensibilize Nano P.

The desensitizing and remineralizing effects of Desensibilize Nano P are potentialized through time by the action of the saliva on the nanoparticles of hydroxyapatite contained in the product. It acts promoting the adhesion between the nanoparticles and their integration in the tooth.

Nano P is the innovative technology of nanoparticles of calcium phosphate, which aims to bring bioactivity to the dental materials.

IT CONTAINS NANOPARTICLES OF HYDROXYAPATITE, THE SAME MINERAL THAT COMPOSES THE TOOTH

1RELEASE OF CALCIUM AND PHOSPHATES5

BIOCOMPATIBILITY2RESISTENCE TO SOLUBILITY6

BIOACTIVITY3EFFECTIVENESS AND LONGEVITY 7

EXCELLENT PENETRATION IN THEDENTIN TUBULES AND IN THEENAMEL MICROCRACKS

4PROVED TECHNOLOGY8

DESENSIBILIZE NANO P, WITH THE EXCLUSIVE NANO P TECHNOLOGY

WHAT IS THE NANO P TECHNOLOGY?

superfi cial area. In addition, its capacity of hydration and wetability allow it to release ions calcium and phosphates to the tooth in the

on the nanoparticles of hydroxyapatite contained in the product. on the nanoparticles of hydroxyapatite contained in the product. on the nanoparticles of hydroxyapatite contained in the product.

Desensibilize Nano P is a high performance paste, for professional use, indicated to:

treatment of hypersensitivity;

prevention of carious lesions in high risk patients;

help in the prevention of the tooth wear by erosion and abrasion;

remineralization of white spot lesions, dental decalcification, pre and post whitening treatment.

1 syringe with 3 g of product and 5 application tips. 1 syringe with 3 g of product and 5 application tips.

INDICATIONS

PRESENTATION

EFFECTIVE AND LONG-LASTING TREATMENT

DESENSITIZATION BY OBLITERATIONDESENSITIZATION DESENSITIZATION DESENSITIZATION DESENSITIZATION DESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATIONDESENSITIZATION BY OBLITERATION

SEE HOW IT WORKS: the new Desensibilize Nano P contains the new Nano P technology,

based on nanoparticles of hydroxyapatite. Its desensitizing performance happens

through two mechanisms:

PHYSICAL EFFECT: for being nanometric, the hydroxyapatite

penetrates more easily in the dentin tubules and

in the enamel microcracks, which diffi cult the

access of external stimuli that cause pain.

CHEMICAL EFFECT: the presence of potassium nitrate

potentializes the desensitization by the depolarization of nerve fi bers;

the presence of fl uoride complements such desensitization effect.

Opened dentin tubules BEFORE the treatment

with the Desensibilize Nano P, enabling

the sensitivity by the exposure to acids, to

heat/cold, to air, to touch.

The obliteration of the dentin tubules

remains INTACT even AFTERTHE EXPOSURE TO ACIDS.

Dentin tubules CLOSED after the

treatment with Desensibilize Nano P,

blocking the diffusion of the

pain-causing stimuli.

The obliteration of the dentin tubules

remains INTACT even AFTERTHE BRUSHING WEAR.

1

2

21

3 4

Nano-hydroxyapatite + saliva: desensitization

with resistance to the acid dissolution

and to the brushing wear.

Desensitizing action of the Desensibilize Nano P throughout the treatment

for the teeth that present initial severe or average (moderate) hypersensitivity. Courtesy of Dra. Constanza Odebrecht and partners of the Vale do Itajaí University – SC, Brazil.

Relief of 80% of

the sensitivity after

the fi rst application

and of 90% after the

second application.

Medium 4,16%

Severe12,5%

% o

f th

e te

eth

in e

ach

leve

l of

sens

itivi

ty

Beginning

Beginning

Immediately after the

1st application

Immediately after the

1st application

Immediately after the

2nd application

Immediately after the

2nd application

Severe 100%

24 teeth

Severe25%

0

100

Medium54,16%

Light 8,33%

Light 62,5%

Null 12,5%

Null20,83%

% o

f th

e te

eth

in e

ach

leve

l of

sens

itivi

ty

Medium100%

19 teeth

Medium21,05%

Medium 10,52%

0

100

Light68,42%

Light 57,89%

Null 10,52%

Null31,57%

EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN

Clinical studies show that Desensibilize Nano P promotes:

RELIEF of the sensitivity IMMEDIATELY after the sole application of the product,

and such effect is POTENTIALIZED THROUGHOUT THE FIRST 48 HOURS BY THE ACTION OF THE SALIVA ON THE NANOPARTICLES OF HYDROXYAPATITE;

EFFECTIVE and LONG-LASTING TREATMENT of the sensitivity.

EFFECTIVE AND LONG-LASTING TREATMENT EFFECTIVE AND LONG-LASTING TREATMENT EFFECTIVE AND LONG-LASTING TREATMENT EFFECTIVE AND LONG-LASTING TREATMENT EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN

EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN

EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN

EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN

EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN

EFFECTIVE AND LONG-LASTING TREATMENT OF THE TOOTH SENSITIVITY IS CLINICALLY PROVEN

1

2

EFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING EFFECTIVE REMINERALIZING EFFECTIVE REMINERALIZING EFFECTIVE REMINERALIZING EFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING ACTIONEFFECTIVE REMINERALIZING EFFECTIVE REMINERALIZING EFFECTIVE REMINERALIZING EFFECTIVE REMINERALIZING EFFECTIVE REMINERALIZING EFFECTIVE REMINERALIZING

Remineralizing potential of Desensibilize Nano P on the surface of bovine enamel affected by

artificial caries lesion, submitted to the pH cycling (des- and remineralization) for seven days.

Different letters show statistic differences (p<0.05).

c

Rec

ove

ry o

f en

amel

’s h

ard

ness

(%

)

c c

b,cb

a

Control CPP-ACP Fluoride in Gel FluorideVarnish

FluorCare (FGM) DesensibilizeNano P (FGM)

0

20

40

60

80

100

The remineralizing action of the Desensibilize Nano P occurs through two mechanisms:

PHYSICAL EFFECT: the nanoparticles of hydroxyapatite penetrate in the

porosities and enamel microcracks, easily integrating itself to the tooth, wich

is also comprised by hydroxyapatite. They repair their deficiencies, functionally

imitating it, acting as a system for the release of calcium and phosphate ions,

essential for the maintenance of the mineral balance of the tooth

in the demineralization conditions.

CHEMICAL EFFECT: the presence of 9,000 ppm of fluoride inhibits the

cariogenic activity of the bacteria and prevents the demineralization.

SEE HOW IT WORKS:

Lab studies show that Desensibilize Nano P promotes:

RECOVERY of 70% of the HARDNESS of the enamel affected by caries.

THE MAXIMUM EFFECT can already be noticed between the 2nd and the 3rd applications of the product.

THE remineralizing EFFECT is POTENTIALIZED throughout the days by THE ACTIONOF THE SALIVA on the nanoparticles of hydroxyapatite.

EFFECTIVE AND LONG-LASTING REMINERALIZATION.

Recovery of 70% of the hardness

1

1

2

3

2

4

c c c

b,cb

a

Wear of the bovine (µm) enamel structure (a) and dentin (b) after the erosive and abrasive demineralization, during five days. Different letters indicate statistical difference (p<0.05).Data given by Souza-e-Silva CM, Moron BM CAB, Magalhães AC, Buzalaf MAR, from Bauru Odontology

University – USP, Brazil.

Wea

r o

f th

e en

amel

’s s

truc

ture

(μm

)

b

a a

Enamel

DesensibilizeNano P(FGM)

DesensibilizeNano P(FGM)

Mi Paste Plus(GC America)

Control0

1

2

3

4

5

6

Wea

r o

f th

e d

entin

’s s

truc

ture

(μm

) bb

a

Dentin

Mi Paste Plus(GC America)

Control0

1

2

3

4

5

6

7

8

9

PHYSICAL EFFECT: the nanoparticles of hydroxyapatite penetrate in the enamel porosity and

microcracks, and also in the dentin, easily integrating itself to the tooth and acting as a system for

the release of calcium and phosphate ions in the conditions of erosive demineralization and abrasion.

CHEMICAL EFFECT: the presence of 9,000 ppm prevents the demineralization.

PREVENTION OF THE TOOTH WEAR BY EROSION AND ABRASION.

SEE HOW IT WORKS:

Its action in the prevention of the tooth erosion and of the abrasion occurs through two mechanisms:

LAB STUDIES SHOW THAT DESENSIBILIZE NANO P IS EFFECTIVE IN THE

1

2

PREVENTION OF THE TOOTH WEARBY EROSION AND ABRASION

STEP BY STEP

For more information, check the technical

profi le available to download on our website.

In case of doubts, check out technical

support: contato@fgm.ind.br or by the

telephone number +55 47 3441 6100.

Dispense the product in a sterile Dappen pot and apply it on the tooth surface, with a micro-applicator (Cavibrush –

FGM), or apply it directly on the tooth surface, with an application tip.

Clean the surface of the tooth and perform the relative isolation. If

necessary, conduct previous prophylaxis.

1

Remove the excess of the product with dry or slightly humid cotton pellet.

Instruct the patient not to eat ordrink for 30 minutes.

5

Leave the product restingfor 5 minutes.

With a felt disk adapted in low rotation with low speed (Diamond Flex – FGM), friction the product during 10 seconds.

34

2

Why the application of the Desensibilize Nano P brings more bene� ts to the remineralization process when compared to the application of other conventional Fluoride-based products?

When a Fluoride-based conventional product is applied on the tooth surface, there is

the formation of calcium fluoride CaF2 on the surface. Such CaF2 is initially stabilized by

proteins and saliva phosphates in neutral pH. However, when the pH falls during acid

challenges, the CaF2 is dissolved, releasing Ca2 and F, which will effectively contribute for

the reorganization of the hydroxyapatite crystals of the tooth in fluorapatite, which can, then,

actuate in a stable manner in the protection of the tooth against cavities. When we apply the

Desensibilize Nano P on the surface of the tooth, we are offering nano- hydroxyapatite for

it and, as we know, the hydroxyapatite is the organized crystal form of calcium phosphate,

which composes the natural tooth, stable to the dissolution. This way, when we apply

the Desensibilize Nano P, we already offer to the tooth a little bit of itself, facilitating the

interaction between the tooth and the product, increasing the probability of formation of

fluorapatite, amplifying the remineralizing potential of the product. In addition, as the nano-

hydroxyapatite contained in the Desensibilize Nano P is highly resistant to dissolution, when it

deposits itself on the tooth, it shall protect the hydroxyapatite of the tooth against dissolution.

In average, how many sessions with the product are necessary to promote the remineralization of the teeth?

Lab studies indicate that, after two applications of the Desensibilize Nano P its maximum

remineralizing effect can already be observed. Based on these studies, for a better safety of

the clinical protocol of application of the product, we recommend 3 to 4 applications of the

Desensibilize Nano P when the purpose is the remineralization of the tooth surface.

QUESTIONS AND ANSWERS

1

In average, how many sessions with the product are necessary to promote the desensitization of the teeth?

The number of sessions may vary, but clinical studies performed (check technical profile)

show that an average of 3 sessions is enough for the efficient and long-lasting treatment of

the tooth sensitivity.

3

2

The Desensibilize Nano P is effective in the prevention of the tooth hypersensitivity related to the teeth whitening?

So far, there aren’t conclusive data that indicate that the application of the Desensibilize Nano P is effective in the prevention of the hypersensitivity related to the teeth whitening.

However, the application of the product after the whitening may contribute for the

remineralization of the enamel surface, and also amplify the sensation of

the whitening, in promoting the flattening of the tooth surface.

The application of the Desensibilize Nano P before the teeth whitening may harm the whitening process?

As the Desensibilize Nano P is comprised by nano- hydroxyapatite, which is the main

constituent of the tooth enamel, the application of the product does not interfere in the

whitening process. On the contrary, we may have a complementation of the whitening

sensation, by the fact that the product may promote the flattening of the tooth surface.

As it is a product with nanoparticles, could it present any risk for the patient in case of ingestion?

Lab studies with cell culture show that the nanoparticles of hydroxyapatite contained in

the Desensibilize Nano P are not toxic for the cells, which brings safety in a situation

of ingestion of the product. Another factor that brings safety to the application of the

Desensibilize Nano P is the fact it releases calcium and phosphate ions when it is

solubilized, and such ions are already regulated (they are part of) by the metabolism of

the individual. The most important care related to high dosages of the Desensibilize Nano P shall be in relation to the presence of the fluoride, which, if ingested in

high quantities, may be toxic. Desensibilize Nano P contains 9,000 ppmF and,

for this reason, it is only indicated for professional use.

4

5

6

DENTINHYPERSENSITIVITY?

EFFECTIVE AND LONG-LASTING TREATMENT.Your patient will thank you.

Desensitizing and Remineralizing Agent

HOW THE PAIN HAPPENS?Heat, cold and citric food, sweets, air and pressure are stimuli that may cause the movement of � uids in the dentin tubules, increasing the pressure inside of them, which stimulates the nerves inside the tooth, resulting in the pain.

+55 47 3441 6100 | www.fgm.ind.br | twitter.com/fgmwhiteness | youtube.com/fgmprodutosodonto | contato@fgm.ind.br

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