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Evolutionary self-organization in molecular networks
Lars Juhl JensenEMBL Heidelberg
huh?
what is self-organization?
patterns emerge
no blueprint
a simple example
an EMBO meeting
fill it with scientists
no seating plan
yet patterns emerge
always the same pattern
but the details vary greatly
social networks
network dynamics
same at the cellular level
protein networks
evolutionary timescale
self-organization
global topology
degree distribution
scale-free networks
hierarchical networks
local topology
network motifs
always the same pattern
but the details vary greatly
cell cycle
S. cerevisiae
synchronized cell culture
microarray time series
periodically expressed genes
protein interactions
temporal network
dynamic and static
de Lichtenberg et al., Science, 2005
just-in-time assembly
not self-organization
evolved via self-organization
cross-species comparison
S. cerevisiae
S. pombe
H. sapiens
A. thaliana
microarray time series
periodically expressed genes
orthology assignment
regulation is not conserved
individual genes
look at a different scale
protein complexes
always the same pattern
but the details vary greatly
multi-level regulation
co-evolution
transcriptional regulation
posttranslational regulation
always the same pattern
but the details vary greatly
Acknowledgments
Ulrik de LichtenbergThomas Skøt Jensen
Søren BrunakPeer Bork