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Enabling Access to Continuous Metabolic Data for Personalized Nutrition and Wellbeing

Ashwin Pushpala

health = fitness + geneticsX

health = fitness + genetics+ metabolism

*Source: Cell Press. "'Healthy' foods differ by individual." ScienceDaily. ScienceDaily, 19 November 2015.

Research* shows high variability in response to identical meals — suggesting universal dietary recommendations may have limited utility.

Participant 1 Participant 2

Banana

Variable sugar response to similar foods

Cookie

Novel silicon sensor technology

Our patented chemical sensing platform and signal-processing

algorithms enable understanding of metabolism and nutrition at the

individual level.

New behavior and habits

Our products can help people establish healthy patterns by giving them

knowledge about what their bodies need and a strategy for how to get

there.

Help millions of people understand what is happening inside their bodies so they can make thoughtful choices about the way they eat, move, and live.

Personalized metabolic insights in real-time

Sano is the world’s first company to give people continuous and

personalized insights into their bodies’ chemistry — bringing personalized

nutrition to all.

We want to fundamentally change the way that people think about diet, nutrition, and metabolism.

Rather than thinking of these as roadblocks, we want people to use their unique metabolic profiles as a strategy for

success.

Rather than thinking of these as roadblocks, we want people to use their unique metabolic profiles as a strategy for success.

*Source: 2015 Sano Consumer Survey (n = 1500)

2 of 3people* say seeing sugar levels

continuously would help them feel better throughout the day by knowing how food

affects their bodies

Sugar is the main culprit for metabolic challenges with nutrition, and it is the first application for our technology.

86%of dieters are looking to cut down

on foods high in sugar

115 millionpeople in the US affected by elevated

blood sugar (almost 50% of adults)

CGM technology is only available to T1 and insulin-intensive T2

patients — the rest of the population managing this chronic

condition can only do so with finger-prick measurements.

DISEASE MANAGEMENT

fitness focused

5mm

We’re starting with the preventive segment of the market unserved by products on the market today.

healthy

40mm

overweight

110mm

pre-diabetic

86mm

T2 diabetic

29mm

insulin-intensive T2 diabetic

1.5mm

T1 diabetic

2mm

PREVENTIVE

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SensePatch continuously senses metabolic data

1 InsightData is visualized in the UI, along with contextualized suggestions for diet, nutrition, fitness, etc.

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Our system continuously collects and analyzes metabolic data to provide actionable, timely insights.

ProcessSmartphone uploads raw sensor data to the cloud, where it is processed and analyzed

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TransmitData is transmitted through BLE to a paired smartphone

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8:09 AM 8:38 AM 9:07 AM 9:36 AM 10:04 AM 10:33 AM 11:02 AM 11:31 AM 12:00 PM 12:28 PM 12:57 PM

sano dexcom finger stick

Our proprietary, transdermal chemical sensing technology platform enables diagnostic-level accuracy in a painless manner.

© 2016 Sano Intelligence, Inc. — CONFIDENTIAL

We’ve made the overarching goal of the product to be quite simple — stabilize sugar concentrations. And we’ve designed a metric (minutes in target zone) that enables people to track this goal in continuously.

Our software is based on continuous feedback loops that happen at 3 different time scales — all focused on helping people maintain stability.

ReflectionReview personalized insights related to what happened during the day to plan future activity and food choices for the next day.

MEDIUM TERM / TODAY

Real-time feedbackSee the impact of recent actions (e.g. heavy lunch) and correct or prevent undesirable situations.

SHORT TERM / NOW

Pattern discoveryUnderstand how habits and behaviors affect personal health and establish new healthy patterns over time.

LONG TERM / HISTORY

Consumer (Glucose)‣ Target audience:

- weight loss- fitness enthusiasts

‣ Features:- Real-time, continuous glucose in normal

zone (70-150 mg/dL)- Time in “stable” glucose region- Information about future glucose trends- Diet programs and/or experiments- Lifestyle & nutrition advice

‣ Regulatory: Enforcement discretion

Our product roadmap starts with a consumer product launch in 2017 aimed at general health/wellness and diet. We will then seek approval for a diabetes-focused product and release other diagnostics.

20182017 2019

Clinical (Glucose)‣ Target audience:

- T1 diabetics- T2 diabetics

‣ Features:- Real-time, continuous glucose at

all concentration ranges- Treatment advice for T2 diabetics

‣ Regulatory: Class III PMA

Other analytes‣ Electrolytes (sodium, potassium, calcium, etc.)‣ Lactic acid‣ Cholesterol‣ Ethanol‣ Cortisol‣ etc.

Team with deep experience in engineering, data science, hardware, manufacturing, supply chain, consumer devices and biochemistry.

THANK YOU

HQ925 Harrison St

San Francisco, CA 94107

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