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Journal club for 2013 Nature article, "Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin.
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Kristen DelevichJournal Club 10/15/13
Prairie vole Montane vole
Insel and Shapiro 1992
125I-OTA bindingOTR and pair-bonding
Photo: Todd Ahern/Emory University/via the San Francisco Chronicle
How to make love like a prairie vole??
Kimberly A. Young, Kyle L. Gobrogge, Yan Liu, Zuoxin Wang 2011
Love and other drugs
photograph copyright Jean-Louis Klein and Marie-Luce Hubert
2013
2012
Complex role of Oxytocin signaling
Do OTergic hypothalamic inputs to NAc even exist in male mice?
Male mice receive substantial OTergic input from PVN but not SON
Oxytocin is required for social CPP
NAc delivery of OT-A sufficient to block social CPP
Cocaine-induced CPP doesn’t require Oxytocin
Oxytocin induces LTD onto NAcc MSNs
Allen Brain Atlas
Social housing engages OT-LTD, OT-LTD targets D1 & D2 NAc MSNs
Oxytocin-induced LTD is presynaptic
Selective ablation of OTRs in cOTR mice
AAV-Cre
Rabies-Cre
Presynaptic OTRs are required for social CPP
OTR-expressing cells that project to NAc
Ruling out vSub and ACC
Dorsal-raphe presynaptic OTRs necessary for social CPP and OT-LTD
NAc projecting dorsal raphe neurons are serotonergic
OT-LTD acts through 5HTR1B 5H
T1R
B a
goni
st5H
T1R
B a
ntag
. + O
T
5HT
1R
B a
goni
st +
OT
ant
ag.
5HTR1B antagonist in NAc blocks social CPP
Circuit Summary
Downstream target?
Mechanism?
2009