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It’s an exciting time to be working in molecular biology right now. In particular the technological advances in sequencing technology, referred to as “next generation sequencing”. These allow DNA to be sequenced on an unprecedented scale, at low cost. This presentation looks at the grand challenges to which NGS can be applied, and takes on the big question; could, if push came to shove, genomics save the world? Presentation given by William Spooner at SciBarCamb on 21st April 2012
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Could genomics save the world?
Will Spooner, CTO, Founder, Eagle Genomics Ltd [email protected]
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Famine Disease
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SyntheticLife
Gaia
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Molecular Psychiatry advance online publication 30 August 2011; doi:10.1038/mp.2011.101
Scientific impact of genomics
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Phen
otyp
e As
soci
ation
PhenotypicAssociation[biomarker]
Stratified Medicine
Right drug
Right patient
Right time
Pharmacogenomics
Genotypic
Transcriptomic
Epigenetic
Genomics in medicine
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Genomics in plant breedingGermplasm/Pedigree
Phenotype/Genotype association
Phenotype Genotype
GenotypingPhenotyping
Assays
Breeding
NGS - democratising genomics
$1000 genome~$0.01 Mbase (30x coverage)
50,000 core supercomputer$1,600/HOUR
Cloud – democratising HPC
Doing Genomics Efficiently
• “Genome Content Management is the set of processes and technologies that support the creating, managing, and reporting of genomic data.”
Create
Man
ag
e
Report
Create
Report
Ext
end
Manage
Share
Reuse
TIMELINE: Bespoke……...Common Models……………Content Management Systems
Open Innovation
ExploreWork together to find a commonpurpose
NurtureBuild trust, shared language
ExploitTurn ideas intotangible benefits
CollaborateEnterpriseAcademiaGovernmentFoundations
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–In under a month (June 2011);• 10 e coli isolates sequenced,• 9 genome assemblies released,• 16 genome annotations released,•Over 50 analyses performed,• Resulting in 12 citable publications
Can genomics save the world?
• Genomics is revolutionising:– Basic research, – Plant breeding, – Healthcare.
• Genomics R&D is empowered by:– NGS, – Cloud computing,
• Collaboration is key– Open knowledge/science,– Public datasets,– Open innovation.
Eagle Genomics
Genome Content ManagementIntegrated, Analysed, Validated,
Except where otherwise noted, this work is licensed under the Creative Commons Attribution 3.0 License
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