Partnerships for Ultra-high Sensitivity LC-MS/MS

CPSA 2012 Vendor Session, Langhorne PA

Gary ValaskovicNew Objective Inc.

gary.valaskovic@newobjective.com

Skilled & Dedicated Staff in a Responsive Environment

Production Engineering

Customer & Technical Support

You!

Partnership for Performance

Customer Partnerships with NOI•PicoChip Development

• Nate Yates, University of Pittsburgh• Neil Kelleher, Northwestern Univesristy• John Yates, Scripps Research Institute• Steve Gygi, Harvard University

•Workshops on Peptide Quantitation• Nalini Sadagopan, Agilent Technologies• Mike MacCoss, University of Washington

•Microspray for Quantitation• Shane Needham, Alturas Analytics, Inc.• Brad Ackerman, Eli Lilly & Co.

•Ultra-nano Separations for Biomarker Studies• Barry Karger, Northeastern University

•Nanospray Source Development • Jarrod Marto, Dana Farber Cancer Institute• Susan Wientraub, UT Health Science

•Heated Column Nanospray

• Sue Abbatiello, Broad Institute• Ken Lewis, OpAns• Neil Kelleher, Northwestern University

•Ultra-low Flow Pump• Jing-Tao Wu, Millenium Pharmaceuticals

•Segmented Flow Nanospray• Bob Kennedy, University Michigan

•Intact Protein Biomarkers• Ying Ge, University of Wisconsion

Corporate Partnerships & Collaborations

Partnership for Performance

When Partnership becomes the future:PicoChip™ system

“We need this to be easy to use . . . .

. . . but we don’t want to give up any performance!”

Nathan YatesUniversity of Pittsburgh

Partnership for Performance

PicoChip™ – Easy to use, high performance nanospray

Complex Specialized expertise

SimpleUniversal productivity

Mount source, connect column to HPLC

Activate column Collect data

Partnership for Performance

“I have a dream – To have a mass spec. based plate reader”

Jing-Tao Wu, Ph.D.

CPSA 2005 Closing Lecture, Princeton NJ

When Partnership becomes the future:

“Chromatography is analog.We need to digitize chromatography. . . “

Mike S. Lee(Circa 1998)

Partnership for Performance

When Partnership becomes the future:Segmented Flow Electrospray

Partnership for Performance

Bob KennedyUniversity Michigan

When Partnership becomes the future:Segmented Flow Electrospray

Sample 4

Sample 5

Sample 6

Sample 1

Sample 2

Sample 3

Pump

ESINano Spray

m/z m/z

Mass Spectrometer

Sample 1

Sample 2

Sample 3

Data Out

Sample 4

Sample 5

Sample 6

Blanks

When Partnership becomes the future:Segmented Flow Electrospray

Sample 4

Sample 5

Sample 6

Sample 1

Sample 2

Sample 3

Pump

ESINano Spray

m/z m/z

Mass Spectrometer

Sample 1

Sample 2

Sample 3

Data Out

Sample 4

Sample 5

Sample 6

Blanks

When Partnership becomes the future:Segmented Flow Electrospray

Sample 4

Sample 5

Sample 6

Sample 1

Sample 2

Sample 3

Pump

ESINano Spray

m/z m/z

Mass Spectrometer

Sample 1

Sample 2

Sample 3

Data Out

Sample 4

Sample 5

Sample 6

Blanks

When Partnership becomes the future:Segmented Flow Electrospray

Sample 4

Sample 5

Sample 6

Sample 1

Sample 2

Sample 3

Pump

ESINano Spray

m/z m/z

Mass Spectrometer

Sample 1

Sample 2

Sample 3

Data Out

Sample 4

Sample 5

Sample 6

Blanks

Thank You!

Partnership for Performance