The common colors of inhibitors

Inhibitors’ are commonly in white, off-white, yellow and colorless. This Slide list

some examples.

Quizartinib White to off-white solidQuizartinib is an orally available small molecule with potential

antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis.

Linaclotide

White Solid Linaclotide is a peptide agonist of guanylate cyclase 2C that is undergoing

clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation.

Bardoxolone methyl

Off-white to yellow powderBardoxolone methyl (also known as “RTA 402” and “CDDO-methyl ester”) is

an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class.

Gadobutrol

White, odorless amorphous powderGadobutrol is a nonionic, paramagnetic contrast agent developed for tissue

contrast enhancement in magnetic resonance imaging (MRI). It has a macrocyclic framework and is neutral.

Reboxetine

Off-White to Pale Beige SolidReboxetine, also called as Vestra, 2-((2-ethoxyphenoxy)benzyl)morpholine

methanesulfonate, exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. Ti is a selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and ADD/ADHD which has been approved for treatment of major depression.