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PROTEIN DEGRADATION

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LIST OF CONTENTS Introduction

Signals for Degradation

Site of Degradation

The Ubiquitin- Proteosome pathway

Lysosomal Proteolysis

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INTRODUCTIONConstant degradation

Half lives

Rapidly degrated proteins are regulatory molecules

E.g Transcription Factors (TF)

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CONTINUED …In Lysosomes and cytosolSignals for degradation• Protein function• Proteins altered by oxidation• Tagged by ubiquitin• N terminal

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THE UBIQUITIN- PROTEOSOME PATHWAY

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A COMPARISON

LYSOSOMAL PROTEOLYSIS UBIQUITIN

PROTEOSOME PATHWAY

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THANK YOU

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MCQS Many rapidly degraded proteins function as

regulatory molecules, such as ______a) Transcriptions factors b) histones

c) silencers d) proteases

The major pathway of selective protein degradation in eukaryotic cells uses_____as marker

a) Ubiquitin b) protease c) beta subunit

d ) lysosome